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    The effects of sugammadex on coagulation in pregnant rats
    (Yuzuncu Yil Universitesi Tip Fakultesi, 2021) Keskin M.E.; Kaplan H.S.; Gülhas N.; Bayram Y.; Basbugan Y.
    Some studies have reported that sugammadex affects coagulation parameters. However, the effects of sugammadex on coagulation in pregnant women have not been adequately evaluated. This study investigated the effects of sugammadex administration on routine coagulation tests and levels of coagulation factors (FII, FV, FVII, FVIII, FIX, and FX) in pregnant rats. After ethics committee approval (2019/06), 24 female Wistar albino rats (n = 12; 19–20 days of gestation; weight 230–380 g) were randomly divided into four groups: control (n = 6), sugammadex (n = 6), pregnant (n = 6), and pregnant sugammadex (n = 6). Ketamine (50 mg/kg) and xylazine (10 mg/kg) were administered intraperitoneally to all groups. Saline (SF) (1 ml/kg) was administered to the control and pregnant groups. Sugammadex was administered to the sugammadex and pregnant sugammadex groups at a dose of 16 mg/kg. Blood samples were collected at 30 min after SF and sugammadex administration in all rats. The levels of PT, INR, aPTT, fibrinogen and coagulation factors were measured in plasma obtained from blood samples. All animals were sacrificed by cervical dislocation after the procedure. The mean weights of the rats were significantly higher in the pregnant groups (pregnant and pregnant sugammadex groups) than in the non-pregnant groups (control and sugammadex groups). The mean PT and INR values were significantly lower in the pregnant than non-pregnant groups. No significant differences were observed in any of the parameters evaluated between the sugammadex-and SF-administered groups. Sugammadex administration did not affect routine coagulation tests or the levels of coagulation factors in pregnant rats. © 2021, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
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    The prevalence of malnutrition in elective surgical patients
    (2006) Çiçek M.; Gedik E.; Gülhas N.; Do?an Z.; Ersoy M.O.
    Aim: Malnourished patients have longer hospital stays, more drug usage, poorer functional capacity and higher morbidity and mortality rates compared to well-nourished patients. To prevent malnutrition in hospitalized patients, physicians should be aware of the fact that every hospitalized patient may be in risk, so that early diagnosis and treatment can be undertaken. The aim of this study was to determine the prevalence of malnutrition with Subjective Global Assessment in elective surgical patients. Materials and Methods: A total of 1355 adult patients from 9 departments were included in this study. Preanesthetic evaluation and Subjective Global Assessment were performed in that order. Results: The departments with highest rates of malnutrition were cardiovascular surgery (28.8%), neurosurgery (24.4%), and general surgery (21.9%). Overall prevalence of malnutrition was 12.8%. The average duration of Subjective Global Assessment was 2.42 min. Conclusion: It was concluded that Subjective Global Assessment is an readily employable after preanaesthetic evaluation.