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    5E modeli’nin öğrencilerin akademik başarısına etkisi: “kuvvet ve hareket” ünitesi örneği
    (İnönü Üniversitesi Eğitim Fakültesi, 2013) Aksoy, Gökhan; Gürbüz, Fatih
    The aim of this study is to compare the effectiveness of 5E model and teaching method and models suggested by course books developed based on Science and Technology teaching program and approved by Ministry of Education on seventh grade students’ academic achievements in the unit “Force and Motion”. The subjects of the study were 57 seventh grade students at a primary school in Erzurum, who were in two different classes and taught by the same teacher at 2011-2012 education year. One of the classes was randomly selected as experimental group (n=27) in which students were thought by means of activities which were prepared according to the 5E model, and the other was determined as the control group (n=30) in which students were thought by teaching method and models suggested by course books developed based on Science and Technology teaching program and approved by Ministry of Education. The main instruments for obtaining data were the Force and Motion Academic Achievement Test (FMAAT). The study results were analyzed by SPSS. The data obtained on instruments were evaluated by using descriptive statistic, independent samples t test, paired sample t test and effect sizes. As the result of the research revealed that experimental group in which students were thought by means of activities which were prepared according to the 5E model is more successful than control group in which students were thought by teaching in control group was carried out teaching method and models suggested by course books developed based on Science and Technology teaching program and approved by Ministry of Education in the unit “Force and Motion”.
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    Neonatal Screening for Congenital Adrenal Hyperplasia in Turkey: Outcomes of Extended Pilot Study in 241,083 Infants
    (2020) Güran, Tülay; Tezel, Başak; Çakır, Meltem; Akıncı, Ayşehan; Orbak, Zerrin; Keskin, Mehmet; Eklioğlu, Beray; Ozon, Alev; Özbek, Mehmet Nuri; Karagüzel, Gülay; Hatipoğlu, Nihal; Gürbüz, Fatih; Çizmecioğlu, Filiz; Kara, Cengiz; Şimşek, Enver; Baş, Firdevs; Aydın, Murat; Darendeliler, Feyza
    Abstract: Objective: Turkish Directorate of Public Health introduced the first pilot screening program for congenital adrenal hyperplasia (CAH) in four Turkish cities in 2017, and in 2018 extended the program, with a slight change in screening strategy, to fourteen cities. To evaluate the performance of the extended study and update previously reported outcomes. Methods: Retrospective, descriptive study. Neonates of ?32 gestational weeks and ?1500 gr birth weight from fourteen cities, born between May-December 2018, were included. Screening protocol included one sample, two-tier testing as applied in the previous pilot study. In the first step, 17?-hydroxyprogesterone (17-OHP) was measured by fluoroimmunoassay in dried blood spots (DBS) obtained at 3-5 days of life. Cases with positive initial screening underwent second tier testing by steroid profiling in DBS using liquid chromatographytandem mass spectrometry to measure 17-OHP, 21-deoxycortisol (21-S), cortisol (F), 11-deoxycortisol and androstenedione. The babies with a steroid ratio (21-S+17-OHP)/F of ?0.7 (increased from ?0.5 in the earlier pilot study) were referred to pediatric endocrinology clinics for diagnostic assessment. Results: In the evaluated period, 241,083 newborns were screened. 12,321 (5.11%) required second-tier testing and 880 (0.36%) were referred for clinical assessment, twenty of whom were diagnosed with CAH (10 females, 10 males). Sixteen were diagnosed as classical 21-hydroxylase deficiency (21-OHD) CAH (12 with salt-wasting and four with simple virilising CAH), and four cases were identified with 11?-OHD CAH. No case of salt-wasting CAH was missed by neonatal screening (sensitivity was 100%). The incidence of classical 21-OHD and 11?-OHD in the screened population was 1: 15,067 and 1: 60,270, respectively. Conclusion: Turkish neonatal CAH screening effectively led to earlier diagnosis of 21-OHD and 11?-OHD, using steroid profiling as a second-tier test. This will result in improved care of these patients in the future.