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    Falls from height: A retrospective analysis
    (Second Affiliated Hospital, Zhejiang University School of Medicine, 2021) Turgut K.; Sarihan M.E.; Colak C.; Güven T.; Gür A.; Gürbüz S.
    BACKGROUND: Emergency services manage trauma patients frequently and falls from height comprise the main cause of emergency service admissions. In this study, we aimed to analyse the demographic characteristics of falls from height and their relationship to the mortality. METHODS: A total of 460 patients, who admitted to the Emergency Department of Inonu University between November 2011 and November 2014 with a history of fall from height, were examined retrospectively. Demographic parameters, fall characteristics and their effect to mortality were evaluated statistically. RESULTS: The study comprised of 292 (63.5%) men and 168 (36.5%) women patients. The mean age of all patients was 27±24.99 years. Twenty-six (5.6%) patients died and the majority of them were in ?62 years old group. The highest percentage of falls was at 0–5 years age group (28.3%). People fell mainly from 1.1–4 metres(m) level (46.1%). The causes of falls were ordered as unintentional (92.2%), workplace (8.1%) and suicidal (1.7%). Skin and soft tissue injuries (37.4%) were the main traumatic lesions. CONCLUSION: Age, fall height, fall place, linear skull fracture, subarachnoidal hemorrhage, cervical fracture, thoracic vertebra fracture and trauma scores had statistically significant effect on mortality. The casualties died because of subarachnoid hemorrhage mostly. © 2018 World Journal of Emergency Medicine
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    Mushrooms: The velvety poison
    (A. CARBONE Editore, 2015) Gürbüz S.; Oguzturk H.; Turgut K.; Turtay M.G.; Guven T.
    Introduction: Mushroom poisoning, a frequent health condition worldwide, documented since ancient times, can occur when an amateur mushroom hunter misidentifies a mushroom due to the close resemblance between toxic and edible species. In the majority of cases, mistakenly ingested mushrooms cause only gastrointestinal irritation, but certain toxic species, such as Amanita phalloides, can cause multiorgan failure and death. This study investigated the demographic and clinical characteristics of 79 mushroom poisoning cases, together with the treatments applied and their outcomes. Materials and methods: A total of 79 adult patients who were admitted to the emergency ward of the medical faculty of Inönü University between 2011 and 2014 were evaluated retrospectively. Results: The 79 patients ranged in age from 18 to 85 years; 44 (55.7%) were female and 35 (44.3%) were male. A total of 62 (78.4%) of the poisoning cases occurred during the spring and autumn seasons, which in Turkey are characterized by the highest levels of rainfall. At admission, nausea was observed in 76 (96.2%) cases, vomiting in 63 (79.7%), abdominal pain in 18 (22.8%), and diarrhea in 3 (3.8%). In 35 (44.3%) cases, toxicity symptoms onset within 6 hours of ingestion and later in 45 (64.5%) patients. A total of 73 patients recovered fully following medical treatment and were therefore discharged; three others received a liver transplant, one of whom survived. The remaining three patients, in whom no transplantations were performed, died; therefore a total of five patients did not survive. Conclusion: Mushroom poisoning can cause serious, potentially fatal illness. Rapid toxin analysis, prompt treatment and liver transplantation decrease the likelihood of mortality.
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    The roles of SFKs in the regulation of proinflammatory cytokines and NLRP3 in familial mediterranean fever patients
    (Academic Press, 2024) İçen Taşkın I.; Gürbüz S.; Koç A.; Kocabay S.; Yolbaş S.; Keser M.F.
    Familial Mediterranean Fever (FMF) is caused by mutations in pyrin, a protein produced in innate immune cells that regulates the development of interleukin (IL)-1? by interacting with caspase-1 and other components of inflammasomes. Although overexpression of proinflammatory cytokines have been observed in FMF patients, no studies have been conducted on the role of Src family kinases (SFKs). The purpose of this study was to examine the impact of SFKs on the modulation of IL-1?, IL-6, IL-8, TNF-?, and NLRP3 inflammasome in patients with FMF. The study included 20 FMF patients and 20 controls. Peripheral blood mononuclear cells (PBMCs) were isolated by density gradient centrifugation. Protein expression levels of SFKs members were measured by western blot. The effect of lipopolysaccharide-induced (LPS) activation and PP2- induced inhibition of SFKs on NLRP3 and IL-1?, IL 6, IL-8, TNF-? were examined by western blot and flow cytometry respectively. Patients with FMF have considerably greater levels of Lck expression. In addition, patients had a substantially greater basal level of NLRP3 than the control group (*p = 0.016). Most importantly, the levels of IL-1 ? were elevated with LPS stimulation and reduced with PP2 inhibition in FMF patients. These results suggest that SFKs are effective in regulation of IL-1 ? in FMF patients. © 2024 Elsevier Ltd