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Öğe Development of Some Antiplatelet Salts as Drug Active Ingredients and Investigation Biological Activities(Springer, 2023) Uslu, Harun; Satilmis, Basri; Uyumlu, Ayse Burcin; Saglik, Begum Nurpelin; Levent, Serkan; Ozkay, Yusuf; Genc, Metin FikretIn this study, prasugrel and prasugrel salts: prasugrel + trans-1,2-cyclohexanedicarboxylic acid (1a), prasugrel + maleic acid (2a), prasugrel + citric acid (3a), prasugrel + oxalic acid (4a), and prasugrel + trometamol (5a) were synthesized and investigated for their biological activities.Ex vivo antiplatelet and in vitro cytotoxic activities were experimentally researched. Antiproliferative activity was not observed for prasugrel and prasugrel salts, and it was also determined that there was no cytotoxic effect. Ex vivo experiments were carried out on diabetic and nondiabetic rats. When the study results were examined, 2a and 3a were seen to be effective prasugrel salts for antiplatelet activity.Öğe Hepatic Arginase - Nitric oxide imbalance: Impact of carcinogenesis and therapeutic effect of sodium channel blockage in an in vivo rat model(Walter De Gruyter Gmbh, 2016) Batcioglu, Kadir; Yildirim, Battal; Satilmis, Basri; Uyumlu, Ayse Burcin; Genc, Metin Fikret; Bentli, Recep; Djamgoz, Mustafa B. A.Objective: Nitric oxide synthase and arginase are frequently antagonistic and interactive, although both use L-arginine as common substrate. Their balance is of potential functional importance. How the balance changes in cancer is unknown. Increasing evidence suggests that progression of carcinomas involves functional voltage-gated sodium channel (VGSC) activity. Methods: The present study extended this study to liver and aimed to determine whether (i) DMBA carcinogenesis would affect the activities of arginase and NOS and (ii) treatment with Na-channel blocker RS100642 would ameliorate the impact of the carcinogen on the arginase-NOS balance. Results: DMBA application significantly increased arginase activity and, correspondingly, the level of L-ornithine by 25-33%. In contrast, NOS activity decreased by 11%. Importantly, RS100642 treatment completely suppressed the effect on arginase. Conclusion: It is concluded (i) that DMBA carcinogenesis changes the hepatic arginase-NOS balance, increasing the overall dominance of arginase and (ii) that VGSC inhibition has a protective effect on liver.Öğe Investigatıon of the Protective Effect of Hydrogen Sulphide Donor Sodium Hydrosulphide and Sulfurized Apricot on Experimental Acute Kidney Injury Induced by Cisplatin in Rats(Assoc Pharmaceutical Teachers India, 2026) Celikoz, Nihan; Yilmaztekin, Yakup; Cankaya, Ozlem; Taslidere, Asli; Datli, Rumeyza Hilal; Uyumlu, Ayse Burcin; Genc, Metin FikretBackground: In the present study, we aimed to investigate the protective effect of Hydrogen acute kidney injury induced by cisplatin in rats. Materials and Methods: Four groups of Wistar albino rats were formed with 10 rats in each group: Control group, Cisplatin group, Cisplatin+SA group, and Cisplatin+NaHS group. The activities of Superoxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GPx) and Cystathione gamma-lyase (CSE), and the levels of Malondialdehyde (MDA), Glutathione (GSH) and total GSH were measured. Creatinine, urea, Alanine Aminotransferase (ALT) were also measured. Results: CAT activity increased in the cisplatin+SA and cisplatin+NaHS groups. CSE activity increased in the cisplatin+NaHS group. MDA levels increased in the cisplatin and cisplatin+NaHS groups. This increase was also observed in SOD and GPx activities but was not statistically significant. Serum ALT, AST, creatinine, and urea levels were higher in the cisplatin group. ADP activity was lower in the cisplatin group. The histological findings support the biochemical results obtained in our study. Red/total GSH was higher in the cisplatin, cisplatin+SA, and cisplatin+NaHS groups. Conclusion: SA and NaHS would have beneficial effects in preventing cisplatin-induced kidney damage.Öğe Patterns and Correlates of Co-occurring Smoking, Alcohol Use, Gambling, and High Internet Use Among University Students: A Cross-Sectional Study in Türkiye(Springer, 2026) Avcu, Ahmet Burak; Gundogdu, Sena Nur; Sulu, Merve; Kekilli, Cengiz Cagdas; Boz, Gulseda; Baran, Ayse; Genc, Metin FikretUniversity life may facilitate multiple addictive behaviors that tend to cluster rather than occur in isolation. The aim of this study was to estimate the prevalence and co-occurrence patterns of daily cigarette smoking, past-30-day alcohol use, gambling, and high daily internet use, and to evaluate their sociodemographic and behavioral associations among undergraduate students in T & uuml;rkiye. This cross-sectional study was conducted at Inonu University (Malatya, T & uuml;rkiye) between February-May 2024. Using stratified random sampling, n = 366 students were included. Outcomes were daily smoking, past-30-day alcohol use, past-year gambling, and high daily internet use (>= 5 h/day). Analysis included UpSet framework for co-occurrence and logistic regression models. A Firth-penalized model assessed smoking factors. Prevalence was 39.1% for high internet use, 30.1% for daily smoking, 22.1% for gambling, and 7.7% for alcohol use. Overall, 59.0% reported at least one behavior, 27.6% reported >= 2, and 10.4% reported >= 3; the most common triple combination was high internet use, smoking, and gambling (6.3%). Male sex was associated with smoking (adjusted odds ratio [aOR] = 3.19) and gambling (aOR = 5.95). Smoking was independently associated with alcohol use (aOR = 5.34) and gambling (aOR = 2.25). High internet use was associated with highest family income (aOR = 2.81), alcohol (aOR = 2.54), and gambling (aOR = 2.73). Peer smoking showed an association with daily smoking (aOR = 17.25 for 2-3 friends vs. none). Risk behaviors are common and frequently cluster, particularly internet use, smoking, and gambling. These findings support integrated campus prevention and screening strategies that address multiple behaviors simultaneously rather than in isolation.Öğe The relationship of the smoking status of students in the school of health and vocational school of health services with the dependent personality trait(2019) Soylemez, Fatma; Genc, Metin FikretAbstract: The purpose of this study is to investigate the relationship between the smoking prevalence and dependent personality trait of the students receiving health education in Bitlis Eren University. The students who were enrolled in and were continuing to attend Bitlis Eren University School of Health and Vocational School of Health Services in the 2011-2012 academic year were selected in the sample. The questionnaires were applied to the students under supervision between December 2011 and January 2012. The mean age of 413 students participating in the study was 20.8, and 49.9% of them were male, and 50.1% were female. While the smoking rate was 29.8% in the sample group, this rate was 45.6% in the male students and 14% in the female students. When the smokers and those who quit smoking were assigned to a group and compared with those who never smoked, the dependent personality scores of the students who were smoking or quit smoking were lower than those who never smoked before (p<0.05). 48.8% of the students with dependent personality were the smokers, and those who quit smoking and 51.2% of the students were never smoked. As a result, it was observed that the smoking prevalence in university students receiving education in the health field was similar to the general population, and the smoking status was related to the dependent personality trait.Öğe Violent Discipline Behaviors in Mothers of Preschool Children in Malatya, East Anatolia(Sage Publications Inc, 2020) Omac Sonmez, Mehtap; Genc, Metin Fikret; Karaoglu, LeylaViolent parenting behavior, whether physical or psychological, give harms to child well-being. This study was conducted to describe and compare the prevalence of discipline methods used by mothers of 2- to 5-year-old children in Malatya, Turkey. This is a cross sectional study and 552 mothers were administered a face-to-face questionnaire describe the methods they use to discipline their children in the year previous the survey. It was observed that nine of 10 women used violence on their children physically and psychologically. The study showed that nine of 10 mothers used physical and/or psychological punishment toward their children in the previous year. Nonviolent discipline was less prevalent than punitive discipline, such as psychological and physical punishment. The most commonly used method was psychological punishment. Significant sociodemographic associations with discipline methods were found. Mother's educational level, family income, child gender, and child age were the independent predictors that explained discipline methods used by mothers. Starting parenting classes and strengthening the child protection systems at national level were suggested.
