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Öğe Evaluation of novel ventricular repolarization parameters in patients with acromegaly(2023) Eren, Hayati; Genc, Selin; Evren, Bahri; Şahin, İbrahimObjectives: T wave’s peak and end interval (Tp-e), Tp-e/QT ratio and Tp-e/QTc ratio are novel markers of ventricular repolarization and are associated with ventricular arrhythmias. Increased ventricular arrhythmia incidence is reported in patients with acromegaly. The purpose of this study is to evaluate ventricular repolarization using the Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio in patients with acromegaly. Methods: Thirty-five patients with acromegaly were included in the study. The control group was consisted of forty-one subjects without acromegaly that having similar age, sex ratio and comorbidities. The Tp-e interval, Tp-e/QT ratio, Tp-e/QTc ratio, and other ventricular repolarization parameters of all patients were evaluated using electrocardiography. Results: Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio were significantly prolonged in patients with acromegaly compared to the control group. Furthermore, Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio showed a significant correlation with plasma GH levels and LVMI values. Conclusions: Our study revealed that Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio are prolonged in patients with acromegaly. We believe that the Tp-e interval, Tp-e/QT ratio, and Tpe/QTc ratio can be used in the evaluation of increased cardiovascular risk in patients with acromegaly.Öğe Evaluation of Serum Endocan and Testosterone Levels in Male Patients with Prediabetes: A Cross-Sectional Clinical Study(Mdpi, 2026) Yigit, Onur Selcuk; Uzanulu, Mehmet Fatih; Genc, Selin; Sahin, IbrahimBackground/Objectives: This study aimed to investigate the relationship between serum endocan and total testosterone levels in male patients with prediabetes. Materials and Methods: This cross-sectional observational study included 37 men with prediabetes and 37 healthy male controls. In addition to routine laboratory tests, blood samples were collected to measure serum endocan levels using the enzyme-linked immunosorbent assay (ELISA), and total testosterone levels were analyzed using a chemiluminescence method. Results: Age did not differ significantly between the groups (p > 0.05). Body mass index (BMI), fasting plasma glucose (FPG), postprandial plasma glucose (PPG), insulin, HbA1c, and serum endocan levels were significantly higher in the prediabetes group (BMI: p = 0.003; FPG: p < 0.001; PPG: p = 0.019; insulin: p = 0.007; HbA1c: p < 0.001; endocan: p = 0.012). No significant difference was observed in testosterone levels between the groups (p = 0.228). Conclusions: Elevated serum endocan levels in individuals with prediabetes may reflect early endothelial dysfunction associated with glycemic dysregulation. These findings suggest that endocan may serve as an exploratory biomarker of early vascular alterations in prediabetes. However, further large-scale and prospective studies are warranted to clarify its clinical relevance and potential role in risk stratification and the prediction of microvascular complications.Öğe Evolving Clinical Features of Diabetic Ketoacidosis: The Impact of SGLT2 Inhibitors(Mdpi, 2024) Genc, Selin; Evren, Bahri; Yigit, Onur Selcuk; Sahin, Ibrahim; Dayanan, Ramazan; Klisic, Aleksandra; Erturk, AyseBackground/Objectives: The antidiabetic effect of SGLT2 inhibitors (SGLT2-is) is based on their ability to increase glucose excretion through urine by inhibiting the kidney-resident SGLT2 protein. Euglycemic diabetic ketoacidosis (EuDKA) is an uncommon but potentially life-threatening adverse effect of these medications, which are notable for their antidiabetic, cardiovascular, and renal protective properties. This study aimed to clarify the impact of SGLT2-is on demographic, clinical, and biochemical characteristics in patients with DKA. Methods: A total of 51 individuals with a diagnosis of DKA were included in the trial; 19 of these patients were treated with SGLT2-is, while 32 were not. Patients diagnosed with DKA and treated with SGLT2-is were compared to those not treated with the medication in terms of clinical, biochemical, and laboratory characteristics. Results: The age of patients utilizing SGLT2-is was statistically considerably greater than that of non-users (p < 0.001). EuDKA was exclusively noted in the SGLT2-is cohort (p = 0.005). Urinary tract infections, vulvovaginitis, and genitourinary infections were substantially more prevalent among SGLT2-i users compared with non-users among both women and the overall patient group (p = 0.036, p = 0.001, p = 0.005, p = 0.003, respectively). Plasma glucose concentrations were significantly higher in SGLT2-i non-users (p = 0.006). Chloride (Cl-) concentrations were elevated among SGLT2-i users (p = 0.036). Conclusions: The study findings indicate that SGLT2 inhibitors may substantially influence age, serum chloride, EuDKA, and the occurrence of genitourinary infections in individuals with DKA.Öğe An unusual cause of hypoglycemia; the case of a male patient with Munchausen's Syndrome(2021) Genc, Selin; Evren, Bahri; Slocum, Ayshe; Bozbay, Abdulkadir; Sener Aydin, Emine; Sahi?n, IbrahimMunchausen's Syndrome is a psychiatric illness in which patients create potentially life-threatening symptoms for the purpose of admission to a hospital or other primary gains. A 23-year-old male patient was admitted to the Inonu University, Turgut Ozal Medical Center Endocrinology Inpatient Unit with hypoglycemic attacks. The patient had hypoglycemia that required intensive dextrose infusion. Studies conducted after his hospitalization revealed that the patient intentionally injected himself with high doses of insulin in order to be hospitalized. A diagnosis of factitious hypoglycemia and Munchausen Syndrome (MS) was made. The patient was followed up with recommendations from the psychiatry department. Factitious hypoglycemia, resulting from deliberate usage of blood glucose-lowering medications in the absence of hyperglycemia, is characterized by frequent episodes of hypoglycemia and recurrent hospitalizations and causes a variety of severe symptoms. Typical signs include low blood glucose levels, suppressed c-peptide and pro-insulin levels, and inappropriately high insulin levels. The purpose behind the current case report is to emphasize the significance of considering MS in the differential diagnosis of patients presenting with hypoglycemia and, although it is more prevalent among females, to demonstrate
