Yazar "Gencdal, Genco" seçeneğine göre listele

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    Changing trends in the etiology of liver transplantation in Turkiye: A multicenter study
    (Kare Publ, 2024) Akarsu, Mesut; Dolu, Suleyman; Harputluoglu, Murat; Yilmaz, Sezai; Akyildiz, Murat; Gencdal, Genco; Polat, Kamil Yalcin
    Background and aim: This study aimed to identify the indications for liver transplantation (LT) based on underlying etiology and to characterize the patients who underwent LT. Materials and methods: We conducted a multicenter cross-sectional observational study across 11 tertiary centers in Turkiye from 2010 to 2020. The study included 5,080 adult patients. Results: The mean age of patients was 50.3 +/- 15.2 years, with a predominance of female patients (70%). Chronic viral hepatitis (46%) was the leading etiological factor, with Hepatitis B virus infection at 35%, followed by cryptogenic cirrhosis (24%), Hepatitis C virus infection (8%), and alcohol-related liver disease (ALD) (6%). Post-2015, there was a significant increase in both the number of liver transplants and the proportion of living donor liver transplants (p<0.001). A comparative analysis of patient characteristics before and after 2015 showed a significant decline in viral hepatitis-related LT (p<0.001), whereas fatty liver disease-related LT significantly increased (p<0.001). Conclusion: Chronic viral hepatitis continues to be the primary indication for LT in Turkiye. However, the proportions of non-alcoholic fatty liver disease (NAFLD) and ALD-related LT have seen an upward trend over the years.
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    The effect of clinicopathologic findings of hepatocellular carcinoma on posttransplant survival: a multcenter cohort from TASL liver transplantation special interest group
    (Elsevier, 2022) Akyildiz, Murat; Gencdal, Genco; Ince, Volkan; Harputluoglu, Muhsin Murat; Bozkurt, Birkan; Zeytunlu, Murat; Kilic, Murat
    [Abstract Not Available]
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    Outcomes following deceased and live donor liver transplantation for the indication of acute liver failure: a multicenter experience
    (Elsevier, 2020) Turan, Ilker; Aladag, Murat; Harputluoglu, Murat; Yilmaz, Sezai; Gencdal, Genco; Polat, Kamil Yalcin; Ozcay, Figen
    [Abstract Not Available]
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    Pre-transplant predictors of 3-Month survival following liver transplantation for acute liver failure in adult and pediatric patients in Turkiye
    (Nature Portfolio, 2025) Turan, Ilker; Akarca, Ulus Salih; Aladag, Murat; Harputluoglu, Murat; Yilmaz, Sezai; Gencdal, Genco; Arikan, Cigdem
    This multicenter retrospective study analyzed 336 patients (236 adults, 100 children) who underwent liver transplantation (LT) for acute liver failure (ALF) between 2002 and 2019 across 14 centers in Turkiye. The aim was to evaluate pretransplant factors influencing short-term posttransplant survival. Median MELD and PELD scores were 31 and 30, respectively. The most common ALF etiologies were viral, indeterminate, and drug-induced causes. Living donor liver transplantation (LDLT) was more common in children (86.0%) than adults (57.2%). Mean posttransplant survival was 166 +/- 9 months in children and 117 +/- 6 months in adults. In adults, LDLT significantly improved survival compared to deceased donor LT (DDLT), with survival of 135 vs. 89 months (p=0.0012). Although pediatric LDLT recipients had longer mean survival than DDLT recipients (167 vs. 132 months), this difference was not statistically significant (p=0.5959). Three-month mortality was associated with low albumin and grade 4 hepatic encephalopathy (HE) in children. In adults, independent predictors of early mortality included DDLT, serum sodium >140 mEq/L, MELD >35, pH <7.3, and grade 4 HE. Our data suggest that LDLT may offer a survival advantage, particularly in adults with ALF. Identifying pretransplant risk factors is essential for improving early outcomes and guiding clinical decision-making.
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    Trends and causes of etiology in adult liver transplant patients: multicenter study
    (Elsevier, 2022) Akarsu, Mesut; Harputluoglu, Murat; Yilmaz, Sezai; Gencdal, Genco; Akyildiz, Murat; Polat, Kamil Yalcin; Dincer, Dinc
    [Abstract Not Available]