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Öğe Anger level and related factors in patients presenting to the emergency department(2021) Gokce, Ayse; Gunes, Gulsen; Gokce, HasanAim: According to reasons for admission, unnecessary patient population increases burden on emergency services and prevents real emergency patients from receiving medical care. Emergency departments frequently encounter acts of violence in various forms as a result of uncontrolled anger. Therefore, this study aimed to demonstrate anger levels and associated factors in patients presenting to the hospital emergency department. Materials and Methods: This descriptive cross-sectional study was conducted on patients who presented to the emergency department of the hospital. The sample size was calculated as 320 using the minimum sampling size formula used when there are an unknown number of individuals in a system. The questionnaire form comprised of two sections. The first section included questions related to sociodemographic characteristics of the patients and various emergency situations; in the second section, the Anger Expression Scale and State-Trait Anger Scale, in which validity and reliability for our country was conducted by Özer (1994), was used. When analyzing the data, student’s t-test and one-way variance analysis test was used for independent samples. Results: The mean age of the individuals who participated in the study was 39.08±18.09 years. While 59.1% of patients preferred emergency admission due to fast medical care, 44.7% had a condition that required emergency assistance. In the comparison of mean state-trait anger and anger expression scores according to degree of urgency, mean state-trait anger scores were 21.75±5.42 in very urgent patients, 20.48±4.80 in urgent patients, and 20.25±5.96 in non-urgent patients (p>0.05); mean anger expression subscores were 18.07±2.88 in very urgent patients, 17.09±2.80 in urgent patients, and 16.47±3.04 in non-urgent patients. Conclusion: Parallel to increased urgency, it was observed that state-trait anger levels were increased and anger expression sub-dimension was more frequently used. This suggests that individuals worrying about their health will be angrier and reflect their anger to those around them more often.Öğe A case of gliosarcoma in a child with neurofibromatosis type 1(2020) Dogan, Gulec Mert; Sigirci, Ahmet; Cengiz, Aslinur; Erbay, Mehmet Fatih; Gokce, HasanGliosarcoma (GS) is a rarely seen form of glioblastoma. These tumors are mostly seen in males older than 60 years of age. It is extremely rare in pediatric central nervous system (CNS) tumors. In this case report, we present a 3-year-old boy with a giant gliosarcoma. Magnetic resonance (MR) imaging and histopathologic findings are discussed. A 3 year-old boy with a clinically diagnosed NF-1 was admitted to the emergency department with a complaint of intractable vomiting. Magnetic resonance imaging (MRI) of the brain was suggestive of a large lobulated mass lesion in the left parietal lobe extending to the vertex and slightly compressing the left lateral ventricle. The final histopathologic diagnosis of the tumor was considered as gliosarcoma. To our knowledge, this case constitutes the first youngest case with neurofibromatosis type 1 reported in the literature in all pediatric cases of GS.Öğe The effect of Hypericum Perforatum on wound healing of oral mucosa in diabetic rats(Istanbul Univ Press, Istanbul Univ Rectorate, 2018) Altan, Ahmet; Aras, Mutan Hamdi; Damlar, Ibrahim; Gokce, Hasan; Ozcan, Oguzhan; Alpaslan, CansuPurpose This study aims to investigate the histopathological and biochemical effects of the topical application of Hypericum perforatum on the healing of surgical wounds created in the oral mucosa of rats with experimentally induced diabetes mellitus. Materials and methods The study was carried out on 48 adult male Wistar albino rats. The animals were divided into two main groups as control and study groups. Two main groups were divided into three subgroups according to the sacrification days. All rats were given streptozotocin 60 mg/kg, after 72 hours, and those having blood glucose levels above 200 mg/dL were included in the study. Mucosal defects were created in the palatal area of the rats. H. perforatum oil was applied topically twice a day to the wounds of the rats in the study group. Animal were sacrificed on the 3rd, 7th and 10th days and samples taken from the palatal wounds were examined histologically and biochemically. Results On the 7th day, ulceration, necrosis, epithelialization, polymorphonuclear leucocytes and hydroxyproline variables showed statistically significant differences (p<0.05). Ulceration, necrosis and polymorphonuclear leukocytes values were higher in the control group, whereas epithelialization and hydroxyproline values were found to be higher in the H. perforatum group. Among 10th-day groups, there was only a statistically significant difference between the values of hydroxyproline, whereas H. perforatum-treated group showed high hydroxyproline levels (p<0.05). Conclusion Topically applied H. perforatum did not create any difference on the 3rd day, but it has positively affected the wound healing on the 7th and 10th days in diabetic rats.Öğe Effect of thymoquinone on transient receptor potential melastatin (TRPM) channels in rats with liver ischemia reperfusion model in rats(Mashhad Univ Med Sciences, 2024) Caglar, Kerem; Dokuyucu, Recep; Agturk, Gokhan; Tumer, Cemil; Tutuk, Okan; Gocmen, Hatice Dogan; Gokce, HasanObjective(s): We aimed to investigate the levels of transient receptor potential melastatin (TRPM) gene expression, and the antioxidant and histopathologic effect of thymoquinone (Tmq) in the hepatic I/R rat model. Materials and Methods: Fifty Wistar rats were divided into 5 groups. Group 1: Control; Group 2: Sham; Group 3: Hepatic I/R (45 min/45 min); Group 4: Tmq (50 mg/kg); Group 5: Tmq+I/R (ten days before I/R at the dose of 50 mg/kg of Tmq). The hepatic I/R (45min/45min) model was performed at the portal vein and the hepatic artery with atraumatic vascular clamp in the ischemia groups. The liver tissues and blood samples that were taken at the end of the study were evaluated for histopathologic and biochemical analysis. Besides TRPM gene expression levels were determined in liver tissues. It was seen that cellular swelling, congestion, PNL, and apoptosis parameters statistically decreased in Tmq and Tmq+I/R groups in comparison with the I/R group in histopathological evaluation. Results: It was observed that biochemical parameters, AST, ALT, GGT, LDH, creatinine, and urea levels significantly increased in the I/R group as compared with, sham, Tmq, and Tmq+I/R groups. It was found that TRPM2,6,7,8 gene expression decreased significantly in Tmq+I/R groups as compared to the I/R group. Conclusion: We showed that thymoquinone can inhibit the entry of Ca+2 into the cell by decreasing TRPM2,6,7,8 gene expression. Based on our findings, we think that Tmq application in the treatment of liver diseases due to I/R damage may be important in terms of both ischemia and apoptosis and can also be used in the treatment of liver-related diseases.Öğe Effects of Alpha-Lipoic Acid on TGF-?1 and Urotensin-II Levels in Glucocorticoid-Induced Osteonecrosis in Rats(Kowsar Publ, 2020) Koca, Irfan; Dokuyucu, Recep; Tas, Zeynel Abidin; Gokce, Hasan; Ozcan, OguzhanBackground: Osteonecrosis (ON) is a serious health problem, which dramatically reduces the quality of life. Objectives: In the present study on the rat model of glucocorticoids (GCs) -induced ON, we explored the influence of alpha-lipoic acid on serum levels of TGF-fi1 and urotensin-II (U-II) and on histological alteration with respect to fatty degeneration and osteocyte necrosis. Methods: A total of 32 male Wistar albino rats were equally assigned to four groups, including control, methylprednisolone acetate (MPA), alpha-lipoic acid (ALA), and MPA with ALA (MP1 + ALA). The animals in MPA group subcutaneously received 15 mg/kg/week during 2 weeks, whereas 100 mg/kg/day ALA was intraperitoneally administered to ALA group during 4 weeks. The MPA + ALA group had both treatments with the same doses. ON was confirmed and graded histologically. Lipid peroxidation and DNA damage levels were immunohistochemically assessed in rats' bones. Results: After histopathological examinations, ALA injection attenuated oxidative stress levels through reducing both 8-OHdG-and 4-HNE-positive cells in the femoral head region (P < 0.05). The U-II and TGF-fi1 protein levels significantly decreased after ALA treatment in MPA injected animals (P < 0.05, P < 0.01, respectively). Moreover, there was a strong correlation between U-II and TGF-fi 1 protein levels (P = 0.019, r = 0.884). Conclusions: This study is novel with regard to showing the therapeutic effects of ALA on GC-inducedONin rats as well as the strong correlation between the expression levels of U-II and TGF-fi1 proteins. In this regard, ALAmaybe a therapeutic agent in the treatment of ON patients.Öğe Effects of Gaseous Ozone Treatment on Bone Regeneration in Femoral Defect Model in Rats(Journal Hard Tissue Biology, 2017) Duman, Ibrahim Gokhan; Davul, Serkan; Gokce, Hasan; Gonenci, Ramazan; Ozden, Raif; Uruc, VedatThe purpose of this study was to investigate the effect of ozone therapy in rat femoral fractures. Following the right open femoral fractures and intramedullary Kirschner wire fixation of the fracture in 60 male Wistar albino rats, the animals were divided into two groups of 30 animals each: ozone therapy group (n=30); non-treatment (control) group (n=30). Ozone was administered by rectal insufflation. After the rats were sacrified fracture healing was assessed by biomechanical and histopathologic evaluation. Histological and mechanical findings indicated that the ozone therapy had a significantly positive effect on bone healing.Öğe The effects of total parenteral nutrition on telomerase expression in rabbit(2018) Gurunluoglu, Kubilay; Bayrakci, Ercan; Gokce, Hasan; Kocbiyik, Alper; Taskapan, Cagatay; Tasci, Aytac; Aksungur, Zeynep; Arslan, Ahmet Kadir; Demircan, MehmetAbstract Aim: Total parenteral nutrition (TPN) is a technique which is use to give vitally mandatory substances in to the venous compartments whenever the gastrointestinal system cannot be used by the patients. Telomerase catalyzes DNA synthesis, which is necessary to maintain telomere length and stabilize the genome to allow continued cell proliferation. In this study, we explored the effects of TPN administration on telomerase reverse transcriptase (TERT) expression in various tissue and serum telomerase level. Material and Methods: In this study a number of 42 same-aged albino, equal number of male and female, new zealand rabbits were use, divided in to three groups. Group 1 rabbits received TPN for 10 days via a central venous catheter. Group 2 received 50 mL/ kg/day physiological saline via a central venous catheter. Group 3 served as the control group. The rabbits were sacrificed after 10 days, and serum telomerase levels were measured by enzyme-linked immunosorbent assay. TERT expression in gonadal, liver, jejunum, and skin tissues were determined immunohistochemically. Blood samples were obtained before and after TPN and saline administration in the TPN and serum saline groups, respectively, and at the end of the experiment in the control group. Results: Telomerase expression in liver, gonads and serum level of TPN group was significantly higher than control and serum saline groups. Conclusion: TPN may be a positive effect in liver and gonadal telomer kinetic. However, we think that TPN increases DNA damage throughout the body.Öğe Germ cell testicular tumor showing spontaneous regression(2018) Cimen, Serhan; Gunes, Ali; Beytur, Ali; Gokce, HasanÖğe The impact of the frozen section analysis on surgical strategy in nodular thyroid diseases(2021) Cicek, Mehmet Turan; Gunduz, Emrah; Bayindir, Tuba; Gunduz, Sumeyye; Gokce, Hasan; Toplu, YukselIn this retrospective cross-sectional study we aimed to investigate of the impact of frozen section analysis (FSA) on the surgical strategy in nodular thyroid diseases. The patients who underwent thyroidectomy (n=293) were analyzed retrospectively and 138 of 293 who had intraoperative FSA results included to the study. All these patients (n=138) also had fine needle aspiration biopsy (FNAB). The patients (n=138) were divided to 5 groups; Group 1 (n=32), Group 2 (n=22), Group 3 (n=12), Group 4 (n=17) and Group 5 (n=55). Twelve of these patients who were reported as “follicular neoplasia” in FSA were excluded from the study. According to the results of FSA (n=126), 48 patients were reported as malignant, whereas 78 patients were benign. The permanent sectional pathological examination (n=126), 57 patients were reported as malignant and 69 were benign. The sensitivity of FSA was found 78.9% and the specificity was found 95.6%, respectively. Also, FSA affected the surgical strategy correctly in 111 (88.1%) and incorrectly in 15 patients (11.9%). As a conclusion of this study we found that frozen section analysis significantly affects the surgical strategy especially in patients whose surgical strategy cannot be determined by FNAB.Öğe Investigation of the Effect of Verapamil on Hepatic Ischemia Reperfusion Injury(Wiley-Blackwell, 2016) Dokuyucu, Recep; Dogan, Hatice; Izmirli, Muzeyyen; Bilgic, Nilufer; Gokce, Hasan[Abstract Not Available]Öğe Investigation of thermal damage in bone drilling: Hybrid processing method and pathological evaluation of existing methods(Elsevier, 2022) Can, Murat; Koluacik, Serdar; Bahce, Erkan; Gokce, Hasan; Tecellioglu, Fahriye SecilIn this study, a hybrid processing method using saline and cryogen cooler is proposed to keep the temperature below the threshold level during bone drilling. Drilling experiments were performed dry, saline, cryogen and, hybrid (saline + cryogen). At the end of the experiment, tool wear, the effect of the methods on the temperature, and the pathological evaluation of the thermal damage were investigated. The advantageous methods for bone drilling were proposed as a hybrid, saline, cryogenic and dry machining, respectively. In addition, it was observed that when cryogen was applied directly to the cutting area, it caused damage to the cell wall structure by the formation of ice crystals in the bone matrix. For this reason, it was recommended to be applied to the body of the cutting tool and it was found that cryogen flow rate has a significant effect on tool wear.Öğe Multifocal low-grade endometrial stromal sarcoma arising from pre-existing endometriosis in a hysterectomised patient: a case report(Taylor & Francis Inc, 2019) Alan, Saadet; Yilmaz, Ercan; Tecellioglu, Fahriye; Akatli, Ayse Nur; Coskun, Ebru Inci; Gokce, Hasan[Abstract Not Available]Öğe Primary endometrial and cervical squamous cell carcinoma in situ, a rare coexistence: case report and literature review(7847050 Canada Inc, 2019) Yilmaz, Ercan; Alan, Saadet; Faydali, Simge; Melekoglu, Rauf; Gokce, Hasan; Kural, HasimAlthough the most common gynecologic tumor of the female genital system is endometrial adenocarcinoma, endometrial squamous cell carcinoma (ESCC) is rarely seen. The presence of ESCC is commonly known as a concomitant tumor secondary to cervical squamous cell carcinoma (SCC). However primary endometrial squamous cell carcinoma (PESCC) is a more rare tumor type. In situ carcinoma, defined as the inflammation of entire intraepithelial tissue with dysplastic cells without identifying any concomitant invasion or metastasis, is considered to be among the precancerous lesions of the female genital system. In situ squamous cell carcinoma cases, especially identified in the cervical region, can be rarely observed in the endometrial tissue. In this case report, the authors aimed to discuss a case of cervical and ESCC in situ which is reported for the first time in the literature.Öğe The Role of Lidocaine on Transient Receptor Potential Melastatin (TRPM) 6,7 Channels in Hepatic Ischemia/Reperfusion Rat Model(Wiley-Blackwell, 2016) Dokuyucu, Recep; Tutuk, Okan; Dogan, Hatice; Izmirli, Muzeyyen; Bilgic, Nilufer; Gokce, Hasan[Abstract Not Available]Öğe Rupture of testicle accompanying multiple traumas: A case report(2020) Ekmekyapar, Muhammed; Turtay, Muhammed; Gurbuz, Sukru; Derya, Serdar; Gokce, Hasan
