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    Analysis of the association between anxiety and depression levels and oxidative stress levels
    (2020) Savrun, Atakan; Savrun, Seyda Tuba; Gokcen, Emre; Aygun, Ali; Kasko Arici, Yeliz; Turkarslan, Murat
    Aim: There is a balance between reactive oxygen species (ROS) and antioxidant systems preventing them in the organism. In cases where this balance is impaired, molecular and cellular functions are negatively affected. Thiol-disulfide homeostasis (TDH) is also affected by this imbalance. It has been reported that the balance between oxidative and anti-oxidative systems is disrupted in individuals with psychiatric diseases such as anxiety and depression. Accordingly, it was aimed to determine the level of TDH in the serum of students who took the oral internship exam.Material and Methods: Volunteer fifth grade students of Medical Faculty, 19 male and 21 female, was included in the study. Of the students included in the study, Beck depression and Beck anxiety, albumin, ischemia-modified albumin (IMA), total thiol (SH + SS), native thiol (SH) and SS levels were measured and SS / SH + SS %, SH / SH + SS % and SS / SH % were calculated before and after the oral internship exam. These data were compared with the association between anxiety and depression level changes before and after the oral internship exam.Results: It was observed that the anxiety levels of the participants before the oral exam decreased in the period after the oral exam (p0.001). It was detected that the level of depression of the participants before the oral exam decreased after the oral exam (p0,05). Conclusion: Oral internship exam of Medical Faculty is a factor increasing anxiety and depression levels of the students. However, no association was found between oral internship exam and TDH parameters.
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    Effect of earthquakes on spontaneous pneumothorax development
    (2020) Savrun, Atakan; Demir, Bilgehan; Savrun, Seyda T; Gokcen, Emre; Caltekin, Ibrahim; Yasar Teke, Hacer; Korkma, Hilal
    Aim: This study researched the effect of earthquakes, affecting meteorological parameters by causing pressure changes in the atmosphere, on the development of spontaneous pneumothorax (SP) and which periods after earthquakes were risky in terms of SP development. Material and Methods: The study retrospectively investigated the files of 117 cases, 4 females (3.4%) and 113 males (96.6%) with spontaneous pneumothorax diagnosis in the emergency service of our hospital within a five-year period. The day patients attended hospital was accepted as the day of pneumothorax formation. Meteorological data for the study period was obtained from the Republic of Turkey General Directorate of Meteorology. Earthquake data for the study period were obtained from the Earthquake Department of the Republic of Turkey Disaster And Emergency Management Presidency website. The correlation of the changes in air temperature, humidity and pressure values of the day on which SP occurred compared to the previous day was investigated with SP. Additionally, risk analysis was performed for the correlation of SP formation time with earthquake days and the time interval after earthquakes.Results: Within the study duration, the number of SP cases on the same day as earthquakes in the region was 27, with earthquake magnitude a minimum of 2.10 and maximum of 4.00 with mean of 2.5±0.47 calculated. Cases attending on days without earthquakes (n=90) were assessed in terms of how many days after the last earthquake they attended and mean duration was 8.14±8.03 days, with attendance due to pneumothorax a minimum of 1 day and maximum 44 days later. As the duration after an earthquake lengthened, there was a statistically significant reduction in the number of attendances.Conclusion: SP is a clinic that can be diagnosed initially by doctor suspicion. In our study, we identified earthquakes were effective on pneumothorax development. As a result, we believe it is necessary to initially consider SP diagnosis for cases attending the emergency department with dyspnea and chest pain complaints in this risky period.
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    Evaluation of red blood cell distribution width and mean platelet volume levels in hypertensive and non-hypertensive epistaxis patients
    (2020) Caltekin, Ibrahim; Demir, Bilgehan; Albayrak, Levent; Atik, Dilek; Gokcen, Emre; Savrun, Atakan; Kaya, Hasan Burak
    Aim: We investigated the development of epistaxis and the effect of red blood cell distribution (RDW) and mean platelet volume (MPV) levels in hypertensive patients compared to non-hypertensive patients. Epistaxis is an urgent rhinologic condition that may manifest itself as recurrent hemorrhages in small quantities or life-threatening hemorrhages. It is known that epistaxis does not develop in every hypertensive patient.Material and Methods: In this retrospective study, the participants were divided into four groups as follows: Group 1 hypertensive epistaxis, Group 2 isolated epistaxis, Group 3 isolated hypertension, Group 4 control. RDW and MPV values were obtained from complete blood count (CBC) samples.Results: There was a statistically significant difference in RDW and MPV blood parameters between all groups (p=0.02). When RDW and MPV blood parameters of Group 1 with hypertensive epistaxis and Group 3 with isolated hypertension were evaluated, there was a statistically significant difference between these two groups in both parameters (p = 0.000, p = 0.011).Conclusion: In our study, we showed that the decrease in RDW and MPV values among the hematological parameters increases the association of epistaxis with hypertension in hypertensive patients compared to non-hypertensive patients.
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    The value of laboratory markers in the differential diagnosis of acute vestibular syndrome
    (2021) Gokcen, Emre; Demir, Bilgehan; Savrun, Seyda Tuba
    Aim: Stroke is one of the leading and most challenging problems in distinguishing between central and peripheral causes of acute vestibular syndrome. This study aims to evaluate the potential utility of neutrophil to lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and gamma-glutamyl transferase (GGT) levels in the differential diagnosis of acute vestibular syndrome. Materials and Methods: This retrospective study included 152 patients diagnosed with vestibular neuritis (VN) and posterior circulation ischemic stroke (PCIS) within the scope of the isolated acute vestibular syndrome (AVS: vertigo, nystagmus, nausea-vomiting, postural instability, and intolerance of head movements). Of all these patients, we listed the ones having normal MRI findings and diagnosed with VN in the department of otorhinolaryngology. The diagnosis of stroke was made through neuroimaging methods (CT and MRI). NLR and GGT levels were compared among the patients diagnosed with VN and PCIS.Results: GGT, NLR, PLR levels were significantly higher in the patients with the PCIS group (p0.05). The AUC (area under the curve) and optimal cutoff values for NLR, PLR, and GGT were analyzed by ROC analysis. According to these results, the diagnostic value of NLR was higher in predicting stroke (AUC: 0.741; 95%CI: 0.652-0.829, p0.001)Conclusion: As a result, NLR, GGT, and PLR can be useful biomarkers for deciding in favor of stroke in the differential diagnosis of VN.