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    The effects of rosuvastatin and pravastatin on bone metabolism in diabetic rats
    (2021) Gokdemir, Gul Sahika; Gokdemir, Mehmet Tahir; Kayhan, Hacer; Yokus, Beran; Tasdemir, Ezel; Gul, Cihan; Baylan, Mukadder
    Aim: In this study, the effects of rosuvastatin and pravastatin on bone metabolism were evaluated. Comparison of the positive or negative effects of two different statins on biochemical parameters related to bone metabolism in 20 mg / kg / day diabetic rats will be contribute to the enrichment of the literature on this subject. In addition, information will be obtained about whether the use of statins will be beneficial in bone metabolism disorders that may occur due to aging or diabetes in DM patients. Materials and Methods: In a diabetic rat model induced by Streptozotocin (STZ), the possible effects of Rosuvastatin and Pravastatin, both of which are hydrophilic, on biochemical parameters and histologycal examination related to bone metabolism (20 mg / kg) were examined in comparison with the control groups. Results: In the intergroup comparisons, Phosphate (P) level was lower in the Pravastatin group than the controls (P = 0.017). However, there was no difference in the P level in the Rosuvastatin group compared to the control group and the diabetes group. The calcium (Ca) level was increased in the Rosuvastatin group then the the controls (P = 0.002). However, there was no significant change in Ca level in the Pravastatin group. The vitamin D2 level of rats was similar in all groups and was not statistically significant. There was no significant difference between the groups in terms of both osteoblastic activity and bone marrow cellularity. Conclusion: In conclusion, although more extensive studies are needed, our study revealed that the serum Ca level was high in rats given rosuvastatin, and P levels were low in rats given pravastatin. But cytologically, there was no change in bone structure. Our study revealed that we should be a little more cautious about the information that statins have a positive effect on bone tissue.
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    Fatigue severity scale, fibromyalgia impact questionnaire, and visual pain scale scores in patients with fibromyalgia
    (2019) Cetin, Abdurrahman; Gokdemir, Mehmet Tahir
    Aim: This study aimed to evaluate and compare the clinical and laboratory results of antinuclear antibodies (ANA)-positive and ANAnegative patients. In addition, it is also intended to determine the fatigue severity scale (FSS), fibromyalgia (FM) impact questionnaire (FIQ), and visual pain scale (VAS) scores in patients with FM in terms of sex and to determine the correlation between them. Material and Methods: A total of 97 patients with FM aged >18 years were included in this retrospective study. Clinical characteristics such as age, sex, and FSS, FIQ, and VAS scores of patients with adequate records and who received a diagnosis of FM through Fibromyalgia Questionnaire Diagnostic Criteria and Severity Scale were analyzed at the physical therapy clinic at our hospital. Results: Of the 97 patients with FM, 88 (90%) were females and 9 (0.92%) were males. The mean age of the patients was 36.71 ± 9.11 years. The mean age of ANA-positive patients was significantly higher than the ANA-negative patients (P = 0.011). Mean level of Alkaline Phosphatase (ALP) in ANA-positive and ANA-negative patients was 59.18 ± 8.56 and 69.98 ± 24.20, respectively, and the difference between them was significant (P = 0.006). Mean FSS and VAS scores were 57.66 ± 4.89 and 6.33 ± 0.86 in males and 55.77 ± 5.69 and 6.63 ± 0.84 in females (P = 0.302, P = 0.310), respectively. Mean FIQ scores were significantly lower in females than in males (P = 0.034). FSS had a strong positive correlation with VAS (r = 0.538, P < 0.001) and FIQ (r = 0.692, P < 0.001). Conclusions: In conclusion, our study showed that an overwhelming majority of patients with FM comprise females, which is consistent with the literature. Mean FIQ scores were significantly lower in females than in males. In our study, the mean age of ANApositive patients was significantly higher than that of ANA-negative patients. The FSS, VAS, and FIQ scores of ANA-positive patients were similar to those of ANA-negative patients.
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    Out-of-hospital cardiac arrests: The effectiveness of prehospital epinephrine use and ventilation management on the short-term survival of patients
    (2019) Gokdemir, Mehmet Tahir; Albayrak, Levent
    Aim: The purpose of this study was to determine the effects of using a bag-valve-mask (BVM) or endotracheal intubation (EI), and administering epinephrine during the transfer of Out-of-hospital Cardiac Arrests (OHCA) cases, and to show the effects of BVM or EI, and epinephrine use on discharge from the hospital and patient survival.Material and Methods: Totally 109 OHCA patients were included in the study. Group 1 included patients in whom return of spontaneous circulation was achieved after Cardiopulmonary resuscitation (CPR) and who were then discharged from the hospital within 30 days. Group 2 included patients who died after emergency CPR or hospitalization. A Student’s t-test was used for normally distributed continuous values, and a Chi-square (χ2) test was used for numerical data.Results: Sixteen (14.7%) of the OHCA cases survived and were discharged within 30 days, and 93 (85.3%) died. The outcomes were similar between those who received endotracheal intubation (EI) and BVM during hospital transfer (p = 0.569). Epinephrine was administered to 15 (19.2%) patients in group 2 and 5 (45.4%) patients in group 1 during the transfer period, but this difference was not significant (p = 0.167). Logistic regression modelling did not find an association between type of airway management, epinephrine use and 30-day discharge survival. Conclusion: The results of this study show that epinephrine had no effect on patient survival or hospital discharge in OHCA patients. Additionally, the effects of EI and BVM on 30-day survival and hospital discharge were similar.
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    Oxidative stress status of individuals involved in traffic accidents
    (Tubitak Scientific & Technological Research Council Turkey, 2012) Ozdemir, Bora; Kaya, Atilhan; Sogut, Ozgur; Kaya, Halil; Gokdemir, Mehmet Tahir; Celbis, Osman
    Aim: To investigate the role of the oxidative stress status of drivers involved in traffic accidents as a risk factor. Materials and methods: Twenty-six drivers and 28 passengers involved in traffic accidents and 31 healthy control drivers and 30 healthy control pedestrians were enrolled in the present study. The total antioxidant status (TAS) and total oxidant status (TOS) were measured in blood samples. Results: The mean value of the TO S level in drivers involved in traffic accidents was significantly higher than that of the control pedestrians (P <= 0.05). The mean value of the TAS level in passengers involved in traffic accidents was significantly lower than that of the control drivers and pedestrians (P <= 0.001 and P <= 0.01, respectively). Conclusion: This is the first study assessing the oxidative markers of individuals involved in a traffic accident compared with a control group. The results reveal that involvement in a traffic accident has an effect on oxidative markers. However, further studies are required in order to use the oxidative stress status of drivers involved in traffic accidents as a marker for estimating the accident risk.
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    Relation of neural tube defects with folic acid use during pregnancy
    (2019) Cetin, Abdurrahman; Gokdemir, Mehmet Tahir; Nas, Cemal; Gokdemir, Gul Sahika
    Aim: The objective of this study was to investigate the rate of neural tube defects (NTD) and the clinical features of newborns of mothers who did not use folic acid (FA) in their pregnancies.Material and methods: The data of a total of 82 newborns, who were diagnosed with meningomyelocele were operated and examined, retrospectively. The newborns were divided into two groups depending on whether their mothers used FA during pregnancy or not. Results: The mothers of 37 (45.1%) newborns used FA during the antenatal period, whereas those of 45 (54.9%) newborns did not.The mean birth weight of the newborns whose mothers did not use FA were lower. Furthermore 9 (25%) newborns whose mothers did not use FA were delivered via cesarean section.The incidence of meningomyelocele was 80% for 45 newborns with NTDs whose mothers did not use FA.Conclusion: Our results revealed that the mean birth weight was lower while the incidence of meningomyelocele was significantly higher in newborn infants whose mothers did not use FA.Keywords: Folic Acid; Pregnancy; Meningomyolocele; Spina Bifida.
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    Use of vena cava inferior collapsibility index and perfusion index in volume status monitoring during intermittent fasting in the ramadan
    (2021) Arac, Songul; Ozel, Mehmet; Zengin, Sehmus; Kanbur, Incifer; Gokdemir, Mehmet Tahir
    Aim: This study aimed to evaluate the hemodynamic status of fasting emergency service professionals by measuring the inferior vena cava collapsibility index (IVCCI) using bedside ultrasonography and the perfusion index (PI) using a noninvasive method and examining the relationship between these two parameters.Materials and Methods: This was a prospective cross-sectional study. The IVCCI and PI were measured in emergency service professionals at 11:00 am, 07:00 pm, and 10:00 pm between May 16 and June 4, 2018, corresponding to the 11th and 20th days of Ramadan. IVCCI and PI levels at different times of fasting and after feeding were compared.Results: The IVCCI-2 value of the volunteers at the 16th hour of fasting was significantly higher than the IVCCI-1 value at the 8th hour of fasting (p 0.001). The IVCCI-3 value at the postprandial 2nd hour after eating was significantly lower than both the average IVCCI-1 at the 8th hour of fasting (p 0.001) and average IVCCI-2 at the 16th hour of fasting (p 0.001). The PI-2 value at the 16th hour of fasting was significantly lower than the PI-1 value at the 8th hour of fasting. The PI-3 value at the postprandial 2nd hour after eating was significantly higher than both the average PI-1 at the 8th hour of fasting (p = 0.001) and the average PI-2 at the 16th hour of fasting (p 0.001).Conclusion: The collapsibility increased at the longest time of fasting, and the collapsibility ratio decreased after eating. Similarly, PI was the lowest at the longest time of fasting, whereas PI increased after eating.