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    Platelet counts in adults with iron deficiency anemia
    (Taylor & Francis Inc, 2009) Kuku, Irfan; Kaya, Emin; Yologlu, Saim; Gokdeniz, Remzi; Baydin, Ahmet
    In adults with iron deficiency anemia (IDA), abnormal platelet counts were seen in several studies. However we retrospectively examined the clinical records of a larger number of adults with IDA to assess abnormal platelet counts. From November 2006 to April 2008, 615 consecutive adults (73 men and 542 women; age range, 16-88 years) with IDA were included in this study. The mean initial hemoglobin was 9.0 perpendicular to 1.8 g/dL (range 2.7-12.8 g/dL), and the mean initial platelet count was 304 x 10(3)/mu L +/- 92.3 (range, 105-700 x 10(3)/mu L). The initial platelet counts were normal in 520 (84.6%) adults with IDA. Thrombocytosis (>400 x 10(3)/mu L) and thrombocytopenia (<150 x 10(3)/mu L) were detected in 82 (13.3%) and 13 (2.1%) adults with IDA, respectively. In conclusion, thrombocytosis was seen at lower rates in our study. Furthermore, this study shows that mild thrombocytopenia is not so rare in adults with IDA.
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    Progesterone Inhibits Human Myometrial Contractions by its Action on Membrane Receptors
    (Cukurova Univ, Fac Medicine, 2013) Gokdeniz, Remzi; Ovayolu, Ali; Garfield, Robert E.
    Purpose: The mechanisms for myometrial inhibition are still being investigated. The aim of this article is to examine mechanisms of progesterone (P4) inhibition of uterine contractility. Methods: Prospective study Tertiary care center at St. Joseph's Hospital and at Maricopa Hospital, Phoenix, AZ and research center in Arizona, USA. During 2010-2011 24 women were given birth by cesarean section. Uterine tissues from women (n= 24) at term were suspended in organ chambers and exposed to various agents. Contractility was recorded and compared before and after addition of agents. Tissues were treated with P4 alone, a progestin (R5020) with low affinity to the progesterone membrane receptor (mPR), or a non-sex steroid (cholesterol). Other tissues were pretreated with inhibitors of adenylate cyclase (SQ 22536), phosphodiesterase (rolipram), nitric oxide ( NO) synthases (L-NAME) or a nuclear P4 receptor antagonist (mifepristone, MIF), followed by P4. Data were analyzed by ANOVA. Results: P4 (P< 0.05) inhibits uterine contractions. R5020 and cholesterol have little P> 0.05) inhibitory effects. P4 inhibition is not blocked by MIF, SQ, ODQ, rolipram or L-NAME ( P> 0.05). Conclusions: P4 rapidly inhibits myometrial contractility by nongenomic mechanisms through action on mPR but not via cAMP, cGMP, or NO
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    Tekrarlayan İnsizyonel Endometriozis: Cerrahide Önemli Olan Nedir?
    (Turgut Özal Tıp Merkezi Dergisi, 1999) Gokdeniz, Remzi; Özen, Süleyman; Aydın, Abdullah; Gürsoy, Nurten
    Endometriozis ekstrapeivik alanlarda da gösterilmiştir ve değişik semptomlara ve tanı proplemlerine neden olur. Burada ciltaltı endometriozis nedeniyle Tekrarlayan cerrahi girişime gereksinim duyulan bir olgu tanıtılmıştır. Ektopik endometriozis 5 yıl önce geçirilen sezaryen sonrası gelişmiştir. Ektopik odak iki kez eksize edilmiş olmasına rağmen hastada semptomlar kısa süre sonra tekrar başlamıştır. Bunun nedeni olarak yetersiz eksizyon düşünüldü. Bu olgu nedeniyle operasyona, endometriotik odağın tüm sınırlarında normal doku ile çevrili olduğu frozen'la gösterildikten sonra son verilmesi gerektiği sonucuna varıldı.