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Öğe Clinicopathological Characteristics and Survival Analysis of Primary Mesenteric Liposarcoma: A Retrospective Study(Mdpi, 2025) Ogut, Zeki; Tuncer, Adem; Dalda, Yasin; Gozukara Bag, Harika Gozde; Bozan, Mehmet BugraBackground and Objectives: Primary mesenteric liposarcoma (LPS) is an exceptionally rare malignancy, with most literature data limited to isolated case reports or small series. This papers aims to evaluate the clinicopathological features, treatment outcomes, and prognostic factors in patients with mesenteric LPS. Materials and Methods: Thirteen patients diagnosed with primary mesenteric LPS between 2010 and 2022 were retrospectively analyzed. Data included demographics, tumor location, histological subtype, surgical treatment, recurrence, and survival. Results: The median age was 56 years (range, 22-74), with a slight male predominance (53.8%). Most tumors arose from the small bowel (53.8%) and colonic (38.5%) mesenteries, with one involving the gastric mesentery. The predominant histological subtypes were myxoid (46.1%) and dedifferentiated (23.1%). R0 resection was achieved in 76.9% of patients. During a median follow-up of 55.2 months, nine patients (69.2%) developed recurrence. Mortality was higher in patients with dedifferentiated LPS (66.7%) than in those with myxoid LPS (40%). Five-year survival rate was 100% in patients without recurrence and 28.6% in those with recurrence (p = 0.112, not significant). Patients who received adjuvant chemoradiotherapy suggested longer survival (110.7 vs. 46.2 months; p = 0.620). Conclusions: This 12-year study highlights the aggressive nature of mesenteric LPS, particularly the dedifferentiated subtype which showed the poorest prognosis. Complete resection remains the primary treatment; however, it has high recurrence rates. To diminish the catastrophic poor results of the postoperative period, multidisciplinary treatment strategies become a keystone.Öğe Estimation of Obesity Levels through the Proposed Predictive Approach Based on Physical Activity and Nutritional Habits(Mdpi, 2023) Gozukara Bag, Harika Gozde; Yagin, Fatma Hilal; Gormez, Yasin; Gonzalez, Pablo Prieto; Colak, Cemil; Gulu, Mehmet; Badicu, GeorgianObesity is the excessive accumulation of adipose tissue in the body that leads to health risks. The study aimed to classify obesity levels using a tree-based machine-learning approach considering physical activity and nutritional habits. Methods: The current study employed an observational design, collecting data from a public dataset via a web-based survey to assess eating habits and physical activity levels. The data included gender, age, height, weight, family history of being overweight, dietary patterns, physical activity frequency, and more. Data preprocessing involved addressing class imbalance using Synthetic Minority Over-sampling TEchnique-Nominal Continuous (SMOTE-NC) and feature selection using Recursive Feature Elimination (RFE). Three classification algorithms (logistic regression (LR), random forest (RF), and Extreme Gradient Boosting (XGBoost)) were used for obesity level prediction, and Bayesian optimization was employed for hyperparameter tuning. The performance of different models was evaluated using metrics such as accuracy, recall, precision, F1-score, area under the curve (AUC), and precision-recall curve. The LR model showed the best performance across most metrics, followed by RF and XGBoost. Feature selection improved the performance of LR and RF models, while XGBoost's performance was mixed. The study contributes to the understanding of obesity classification using machine-learning techniques based on physical activity and nutritional habits. The LR model demonstrated the most robust performance, and feature selection was shown to enhance model efficiency. The findings underscore the importance of considering both physical activity and nutritional habits in addressing the obesity epidemic.Öğe Factors associated with complications of parathyroidectomy in the elderly: A single-center experience(2025) Gozukara Bag, Harika Gozde; Dalda, Yasin; Öğüt, Mehmet Zeki; Isik, BurakAim: The expanding older adult population has led to a corresponding increase in parathyroidectomy procedures among geriatric patients. Due to the prevalence of comorbidities and reduced physiological reserves, elderly patients may experience a greater incidence of postoperative complications. This study aims to evaluate the relationship between clinical parameters and complications associated with parathyroidectomy in individuals aged 65 years and above. Materials and Methods: This is an observational study included patients aged 65 years and older who underwent parathyroid surgery at a tertiary care center between January 2009 and February 2022. Demographic, clinical, surgical, and laboratory data were analyzed. Patients were divided into two groups according to the presence or absence of postoperative complications. A subgroup analysis was conducted for patients who developed permanent hypocalcemia. Statistical comparisons were made between groups. DEXA T scores were obtained from the lumbar spine and hip regions. Results: Elderly patients accounted for 5.9% (23/388) of all parathyroidectomy cases. The overall postoperative complication rate was 21.7%, and the rate of permanent hypocalcemia was 17.4%. Statistically significant differences were found between the patients with and without complications in terms of free T3, preoperative ALP, PTH, and postoperative calcium levels. Histopathological findings (adenoma vs. hyperplasia) and the number of excised adenomas were significantly associated with complications and permanent hypocalcemia. Mortality was significantly higher in the complication group (p=0.017). No cases of persistent hyperparathyroidism were observed during follow-up. A significant association was found between preoperative phosphorus levels and DEXA T-scores. Conclusion: Parathyroidectomy in elderly patients carries a notable risk of postoperative complications. Identifying high-risk patients based on clinical and biochemical parameters may help guide preoperative planning and postoperative monitoring.Öğe Protective effects of crocin on acrylamide-induced testis damage(Wiley, 2021) Gul, Mehmet; Kayhan Kustepe, Elif; Erdemli, Mehmet Erman; Altinoz, Eyup; Gozukara Bag, Harika Gozde; Gul, Semir; Gokturk, NurcanExposure to acrylamide (Ac) through food is almost inevitable and this kind of toxicity may cause lifelong harm. In present study, we researched effects of Crocin (Cr) on testis histopathology in Ac-induced testis of rats. Adult male rats were grouped as: group 1, 1 ml saline only; group 2, 50 mg/kg Cr only; group 3, 25 mg/kg Ac only and group 4, 25 mg/kg Ac + 50 mg/kg Cr. All administrations were given as 1 ml/day by gavage for 21 days. It was found that Ac adversely influenced the levels of FSH, testosterone and LH in the blood serum; malondialdehyde (MDA), total antioxidant status (TOS), oxidative stress index (OSI)/ glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), total antioxidant status (TAS) oxidant/antioxidant parameters in testis tissue (p < .01) and the histopathological parameters like Johnson's score, seminiferous tubule diameter, seminiferous epithelial height and H-score for caspase-3 immunoreactivity. In contrary, Cr treatment resulted in increase in testosterone, follicle stimulating hormone (FSH), luteinizan hormone (LH) levels and SOD, CAT, GSH, TAS levels (p < .01) and improved all the histopathological changes. In conclusion, Cr has a promising protective potential against Ac-caused toxic damages in testicular tissue.
