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    A Cross-sectional, Comparative Study of Oxidative Metabolism and Oxidative DNA Damage in Adult Attention Deficit and Hyperactivity Disorder
    (Yerkure Tanitim & Yayincilik Hizmetleri A S, 2020) Aksoy, Ihsan; Gucyetmez, Volkan; Kilic, Osman Hasan Tahsin; Unal, Ahmet; Altindag, Abdurrahman
    Objective: Changes in oxidative metabolism are increasingly gaining attention as an important factor for many medical illnesses such as carcinogenesis and psychiatric disorders including ADHD. Only a handful of studies have investigated the possible relation between adult attention deficit and hyperactivity disorder (A-ADHD) and oxidative stress. However, we found no research about its relation to oxidative DNA damage. Methods: The study comprised of 43 A-ADHD patients and 30 healthy controls. Serum total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels were measured and compared in a cross-sectional design. Results: No difference was observed in terms of oxidative stress and oxidative DNA damage across groups. Patients with comorbid psychiatric diagnosis had significantly increased TOS and OSI levels than patients with A-ADHD alone, although their comorbidity was in remission. Conclusion: According to our results, oxidative balance among adult ADHD patients were not impaired, this was discordant with the majority of the findings of the studies performed in children and adolescents and animals. Oxidative stress may not have a specific role in the etiopathogenesis of ADHD in adults. It is more plausible that other factors such as comorbid disorders affect and confound oxidative stress in adult population.