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Öğe Analysis of manganese superoxide dismutase (MnSOD: Ala-9Val) and glutathione peroxidase (GSH-Px: Pro 197 Leu) gene polymorphisms in mood disorders(Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, 2013) Cumurcu, Birgul Elbozan; Ozyurt, Huseyin; Ates, Omer; Gul, Isil Gogcegoz; Demir, Suleyman; Karlidag, RifatWe investigated the etiopathogenetic role of manganese superoxide dismutase (MnSOD) (Ala-9Val) and glutathione peroxidase (GSH-Px) (Pro 197 Leu) gene polymorphisms in patients diagnosed with major depressive disorder (MDD) and bipolar I disorder (BD). Eighty patients with MDD, 82 patfents with BD (total 162 patients) and 96 healthy controls were enrolled in this study and genotyped using a Real Time-Quantitative Polymer Chain Reaction (RT-qPCR)-based method. The patients with BD and MDD and the controls had a similar distribution of the genotypes and alleles in the Ala-9Val MnSOD gene polymorphism. Comparison of the MDD group and control group regarding the Pro 197 Leu GSH-Px gene polymorphism revealed similar genotype distribution but different allele distribution. The BD group and control group were similar both for genotypes and for alleles when compared regarding the Pro 197 Leu GSH-Px gene polymorphism. The combined analysis (MDD plus BD) also failed to find any association between the Ala-9Val MnSOD and Pro 197 Leu GSH-Px gene polymorphism. Although small statistical power of the current study the significant difference between patients with depression and the control group for the Pro 197 Leu GSH-Px polymorphism indicates that the distribution of these alleles may have a contribution in the physiopathogenesis of depression. One of the limitation of the current study is that the sample size is too small. Understanding of the exact role of Pro 197 Leu GSH-Px polymorphism in the development of depression needs to further studies with more sample size and high statistical power. (C) 2013 Association of Basic Medical Sciences of FB&H. All rights reservedÖğe The Changes in Tear Film Parameters and Impression Cytology in Heavily Drinking Men(Lippincott Williams & Wilkins, 2013) Cumurcu, Tongabay; Gunduz, Abuzer; Cumurcu, Birgul Elbozan; Gul, Isil Gogcegoz; Akpolat, Nusret; Karlidag, RifatPurpose: To evaluate the tear film function and ocular surface changes in heavily drinking men. Methods: This prospective case-control study involved 35 male subjects with heavy alcohol consumption (group 1) and 35 age-and sex-matched control subjects (group 2). Best-corrected visual acuity measurement, slit-lamp examination, Schirmer I test, tear film break-up time (BUT) measurement, and conjunctival impression cytology were performed in all subjects. The results were compared between the 2 groups. Results: The mean Schirmer I test results in group 1 and group 2 were 8.31 +/- 3.56 mm and 13.17 +/- 5.71 mm, respectively, and the mean BUT values were 9.22 +/- 3.10 seconds and 13.20 +/- 4.04 seconds, respectively. The mean Schirmer I and BUT results were statistically lower in group 1 than in group 2 (P < 0.0001). The mean impression cytology scores in group 1 and group 2 were 2.08 +/- 0.78 and 1.37 +/- 0.94, respectively. A statistically significant difference was noted between the study and control groups for the grading of cytological changes (P = 0.001). Conclusions: Our data showed that heavily drinking men have decreased tear production, tear film instability, and significant degeneration of the ocular surface epithelium when compared with normal subjects.Öğe GHRELIN AND LIPID LEVELS IN PANIC DISORDER BEFORE AND AFTER TREATMENT AND THEIR RELATIONSHIP WITH AGORAPHOBIA(Medicinska Naklada, 2015) Gul, Isil Gogcegoz; Cumurcu, Birgul Elbozan; Karlidag, Rifat; Turkoz, YusufBackground: We aimed to evaluate serum ghrelin (GHR) levels and lipid profile in panic disorder (PD), with and without agoraphobia, and to compare these parameters before and after treatment. Subjects and methods: The GHR and lipid profiles were measured in blood samples taken from 31 PD patients with agoraphobia, 22 PD patients without agoraphobia, and 53 control group subjects. 23 of the 53 patients who were prescribed 20 to 40 mg/day paroxetine had continued treatment. The 23 patients who had continued treatment were measured again at the end of twelve weeks. Results: The GHR and triglyceride (TRG), total cholesterol (Total-C), low-density lipoproteins (LDL-C), and very low-density lipoproteins (VLDL-C) levels were higher in the PD with agoraphobia group than the PD without agoraphobia and control groups. The 23 patients that had continued their treatment were re-evaluated, and the serum GHR, Total-C levels, and BMI after treatment were significantly decreased, compared to the values before treatment. Conclusions: There may be a pathophysiological relationship between the GHR and lipid profiles that interact with each other in PD. In fact, this relationship was more marked in PD with agoraphobia than in PD without agoraphobia.Öğe P50 sensory gating in patients with vaginismus(Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2015) Gul, Isil Gogcegoz; Karlidag, Rifat; Ozcan, A. CemalObjective: P50 sensory gating was investigated in patients with primary vaginismus (PV) with the hypothesis that interpreting coping capacities as a stress factor during sexual intercourse by perceiving unrelated stimuli and an impairment of the sensory information processing may be associated with fear/anxiety related to a possible pain in vulvovagina. Methods: A total of 35 patients who were diagnosed with PV and 29 healthy volunteers matched for age and gender underwent P50 recording in the neurophysiology laboratory and the results were compared. Results: The PV group's P50 gating ratio and S1 amplitude were statistically significantly lower than in the control group. Conclusion: Sensory gating is required for filtering the stimuli coming to the brain and developing an appropriate behavioral response. The reduced formation of an appropriate behavioral response in the PV group can lead to a perception of excessive and unrelated stimuli coming from internal and external environments and interpreting these as a stress factor exceeding the capacity to cope. Our study is the first to evaluate sensory gating in PV patients and new studies with larger patient groups are required.Öğe Psychotic Disorder Releated with Graves Disease: A Case Report(Turkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegi, 2012) Gul, Isil Gogcegoz; Kartalci, Sukru; Karlidag, Rifat; Cumurcu, Birgul ElbozanAlthough the association between disorders of thyroid function and psychiatric symptomatology is well established, psychoses associated with hyperthyroidism are uncommon. Behavioral abnormalities that may extend to psychosis can be a manifestation of severe hyperthyroidism due to Graves' disease. In this case report, we present a 39-year-old man who developed a psychotic disorder due to Graves' disease. (Archives of Neuropsychiatry 2012; 49: 317-319)Öğe Recurrent priapism during quetiapine treatment(Kure Iletisim Grubu A S, 2010) Kartalci, Sukru; Gul, Isil Gogcegoz; Karlidag, Rifat; Cumurcu, Birgul ElbozanPriapism is defined as prolonged penile erection without sexual desire or stimulation. Since it is a urological emergency, serious consequences can occur if neglected. Different etiological factors including hemotopoetic disorders, malignancies, various drugs, perineal trauma, etc. can cause priapism. Drug induced priapism can occur during treatment with antispychotic medications. This report discusses a case of priapism, which occurred when the dose of quetiapine was increased.
