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    The effects of fibroblast growth factor-2 and ozone therapy on acute kidney injury in renal ischemia/reperfusion injury
    (Parlar Scientific Publications, 2020) Bahar L.; Gul M.; Resitoglu B.; Celik Y.; Erturk S.E.; Gul S.
    Renal ischemia/reperfusion (I/R) injury is the most common risk factor for AKI. The study aimed to investigate the effects of FGF-2 and ozone applications on the kidneys of rats with hypoxic-ischemia. Six groups were formed with seven pups in each: sham control, ischemia-reperfusion (I/R), FGF-2(10-1/ml); FGF-2(20 ul/ml), ozone (25 mg/kg), and ozone (50 mg/kg) groups. After the tissue processing and staining of the kidney samples, the renal injury was scored and data were analyzed. Manifestations of collapse and sclerotic changes in the glomeruli, observations of collapse in the Bowman's space, ex¬ cessive accumulation in the ultrafiltrate and dilata¬ tion was noted in the I/R group. The average diame¬ ter of the glomeruli and the scores of injury were sig¬ nificantly different between the I/R and FGF20 groups and the I/R and Ozone 50 groups (p<0.05). The histopathologic assessment showed that the treatment with FGF-2 or ozone had renoprotective effects against renal damage caused by I/R in a dose-dependent manner. This study may discover a new therapeutic strategy for the treatment of AKI based on specified pathogenesis. This study found the FGF-2 and ozone applications to be beneficial for the treatment of AKI at the cellular level with certain doses. © 2020 Parlar Scientific Publications. All rights reserved.
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    Effects of glucagon as a neurohormone on the central nervous system and glucose homeostasis
    (Verduci Editore s.r.l, 2024) Tanbek K.; Yilmaz U.; Gul S.; Koç A.; Gul M.; Sandal S.
    OBJECTIVE: This study aimed to elucidate the possible effects of the acute/ long-term infusion of glucagon in the brain as the regulatory role on the endocrine secretions of the pancreas. MATERIALS AND METHODS: Ninety male Wistar albino rats were divided as Control, artificial Cerebrospinal Fluid (aCSF) (120 min), Glucagon (120 min), pancreatic denervation (PD)+aCSF (120 min), PD+Glucagon (120 min), aCSF (7 days), Glucagon (7 days), PD+aCSF (7 days) and PD+Glucagon (7 days). Glucagon and solvent (aCSF) were administered after pancreatic denervation (PD) by Hamilton syringe and osmotic mini pump (1 µg/10 µl/min) in the third ventricle of the brain. RESULTS: Acute intracerebroventricular (icv) administration of glucagon resulted in an elevation of glucagon levels and a concurrent reduction in blood glucose levels. Furthermore, in both the PD+aCSF (7 days) and PD+Glucagon (7 days) groups, there was a notable decrease in propiomelanocortin (POMC) and agouti-related protein (AgRP). Significant changes were observed in feed consumption and body weight, as well as pancreatic glucagon levels, with a simultaneous decrease in insulin levels in the PD (7 days), Glucagon (7 days), and PD+Glucagon (7 days) groups. These alterations were statistically significant when compared to the control group (p<0.05). CONCLUSIONS: The research outcomes established that pancreas-secreted glucagon functions as a neurohormone within the brain, activating central pathways linked to blood glucose regulation. The presence of glucagon led to a decrease in POMC levels. Surprisingly, this reduction in POMC resulted in the suppression of AgRP. Contrary to expectations, the suppression of AgRP led to an increase in food intake rather than a decrease. As already highlighted in the results section, it was emphasized that POMC may play a more significant role than AgRP in influencing feeding behavior. © 2024 Verduci Editore s.r.l. All rights reserved.
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    K-nearest unrepeatable cell graph model of histopathological tissue image
    (Institute of Electrical and Electronics Engineers Inc., 2015) Serin F.; Erturkler M.; Gul M.
    One of the most important components in the histopathological tissue images is the cell nuclei. Features such as the number, morphological properties and location of the cell nuclei offer useful information for histopathological analysis. Cell-graph models are constructed using location information of cell nuclei and important distinctive information can be obtained from the features of the models. The models are generally formed according to the distance between the cell nuclei. However, the distance between the cell nuclei is affected by various factors during obtaining tissue image and shows variety. In this study, using one-way neighborhood relationship of the nuclei with each other is proposed for the construction of the cell-graph models of histopathological images. The proposed approach has been tested on 20 healthy and 20 necrotic liver tissue images. The results show that graph models constructed by the neighborhood relationship, have more distinctive characteristics than distance-based graph models. © 2015 IEEE.