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Öğe Comparison of hydrophobic properties of thoracic duct lymph chylomicrons from rats given different fats or oils by gavage(Wiley, 2014) Kaya, K.; Isikgil, O.; Guldur, T.Lipoprotein aggregation is generated by hydrophobic nature of lipoproteins that is known to be one of the causes of atherosclerosis. Low density lipoproteins (LDL) has been extensively studied in this respect but not chylomicrons. There is strong evidence that post-prandial triacylglycerol-rich lipoproteins are atherogenic. Because biophysical properties of lipoproteins are largely determined by their lipid compositions, hydrophobic nature of thoracic lymph duct chylomicrons obtained from rats given different fats or oils by gavage was investigated by vortexing-induced aggregation and hydrophobic interaction chromatography. Contrary to LDL, vortexing did not cause aggregation in chylomicrons. Vortexing of fish oil and butter chylomicrons resulted in more prominent reduction in absorbances compared with chylomicrons from other sources that might indicate less micelle stability. Hydrophobic interaction chromatography of fish oil, palm oil and olive oil chylomicrons yielded three fractions, whereas that of sunflower, margarine and butter chylomicrons gave rise to two fractions. These results suggest that surface hydrophobicity of chylomicrons might be heterogenous. Our results also demonstrate that fish oil chylomicrons have less hydrophobicity and lower stability against vortexing compared with chylomicrons from other sources. Considering beneficial effects of fish oil in cardiovascular health, less hydrophobicity together with lower stability might provide an additional atherogeneicity index for lipoproteins.Öğe Effects of various conditions related to circadian rhythm disturbances on plasma and erythrocyte lipids: a peroxisomal perspective(Wiley, 2021) Otlu, H. G.; Ugur, Y.; Yildiz, A.; Erdogan, S.; Yologlu, S.; Vardi, N.; Guldur, T.[Abstract Not Available]Öğe Investigation of age, sex and menstrual stage variation in human cerumen lipid composition by high performance thin layer chromatography(Cambridge Univ Press, 2008) Kocer, M.; Guldur, T.; Akarcay, M.; Miman, M. C.; Beker, G.Objective: The objective of the study was to correlate quantitative changes in the lipid composition of human cerumen with changes in age, sex and menstrual cycle stage. Design: Cerumen samples were collected from the external ear canal and analysed using sequential, one dimensional, high performance thin layer chromatography. Subjects: The following age groups of both sexes were investigated: one to 10 years, 11-18 years; 19-40 years; and 40 years and over. Additionally, cerumen samples from subjects in three stages of the menstrual cycle were compared. Results: In the cerumen samples, the peak values for wax ester and cholesterol occured between the ages of one and 10 years for both sexes. However, squalene and triglyceride content reached maximum levels at puberty. Men aged 19-40 years had a significantly greater percentage of cerumen lipid squalene content than women from the same age group; however, their cholesterol content was found to be lower. Regarding the various menstrual cycle stages, cerumen samples taken at the follicular stage from women aged 19-40 years had a significantly lower free fatty acids content, and higher cholesterol and squalene levels, compared with samples taken in the luteal or menstrual stages. Conclusion: The proportions of the lipid constituents of cerumen varied with age, sex and menstrual stage. In cerumen, the main lipid constituent stimulated at puberty appears to be squalene, not wax esters as reported for sebum. The relevance of lipid constituents to cerumen's protective role is discussed.Öğe Investigation of o-alkyl/o-alkenyl glycerolipid ratios in erythrocyte lysates of patients with obstructive sleep apnea(Wiley, 2021) Koc, E.; Ermis, H.; Bag, G. H. Gozukara; Dundar, M.; Guldur, T.[Abstract Not Available]
