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Öğe Evaluation of Pharmacokinetics and Biodistribution of Targeted Nanoparticles(Taylor and Francis, 2021) Ates M.; Izat N.; Kir F.; Gulsun T.; Sahin S.Nanotechnology attracts more attention day by day in the field of pharmacy as in many fields. This chapter discusses the biodistribution and pharmacokinetic (PK) properties of nanoparticles, the factors affecting these properties, and studies for assessment. Physiologically based pharmacokinetic modeling (PBPK) is a powerful descriptive tool that mechanistically describes the PK and/or pharmacodynamic behaviors of drugs by using models and simulations with combined considerations of physiology, population, and drug characteristics. The chapter highlights PBPK applications for the PK evaluation and formulation development of nanoparticles. PBPK models are valuable tools to understand and predict the in vivo reflection of changes in formulation design and development factors. Using the dissolution- and distribution-based model, the observed in vivo situation was described successfully by establishing an in vitro–in vivo correlation between physicochemical characteristics of the formulation and clinical data. © 2022 Jenny Stanford Publishing Pte. Ltd.
