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Öğe Antimicrobial activity and characterization of some phenolic compounds of Inula peacockiana (Aitch. & Hemsl.) Krovin(Georg Thieme Verlag Kg, 2011) Gokbulut, A.; Sarer, E.; Gunal, S.[Abstract Not Available]Öğe Antimicrobial activity and simultaneous determination of some phenolic compounds of Inula helenium (L.) ssp turcoracemosa(Georg Thieme Verlag Kg, 2012) Gokbulut, A.; Sarer, E.; Gunal, S.[Abstract Not Available]Öğe Antioxidant and antimicrobial activities, and phenolic compounds of lnula thapsoides ssp thapsoides(Georg Thieme Verlag Kg, 2013) Gokbulut, A.; Gunal, S.; Sarer, E.[Abstract Not Available]Öğe COMPOSITION AND ANTIMICROBIAL ACTIVITY OF THE ESSENTIAL OIL OF Achillea formosa subsp amanica(Springer, 2011) Kucukbay, F. Z.; Kuyumcu, E.; Gunal, S.; Arabaci, T.[Abstract Not Available]Öğe The effect of vaginal microbiota on the outcome of assisted reproductive technologies(Oxford Univ Press, 2020) Karaer, A.; Dogan, B.; Tuncay, G.; Gunal, S.; Tecellioglus, A. N.[Abstract Not Available]Öğe Investigation of in vivo radioprotective and in vitro antioxidant and antimicrobial activity of garlic (Allium Sativum)(Verduci Publisher, 2012) Batcioglu, K.; Yilmaz, Z.; Satilmis, B.; Uyumlu, A. B.; Erkal, H. S.; Yucel, N.; Gunal, S.OBJECTIVE, In this study, we aimed to assess the in vivo antioxidant potential via evaluating radioprotective effects in kidney and liver tissues of rats and in vitro antimicrobial and radical scavenger activity of garlic extract. MATERIALS AND METHODS, Thirty-two mature female Wistar rats were divided into four groups, each consisting of eight rats. Experimental groups were control group (1), GE group (2), irradiation group (3) and both GE and irradiation group (4). For the rats in two groups (group 3 and 4), irradiation was performed on a Cobalt-60 unit using a single fraction of 20 Gy. The GE was given to rats once a day during the month before irradiation and continued for five days after irradiation. The garlic cloves were peeled on crushed ice and 50 g of garlic was cut into small pieces and homogenized in 75 mL of 0.9% NaCl. The concentration of this garlic preparation was considered to be 500 mg/mL on the basis of weight of the starting material (0.5 g/mL). This extract was administered to rats by oral gavage. RESULTS, Our findings suggest that the use of garlic extract could be useful for addressing the limited therapeutic gain due to the radiation sensitivity of normal tissues adjacent to the tumour which are exposed to radiation, by strengthening the antioxidant system. In vitro and in vivo experiments seem to yield similar conclusions. CONCLUSIONS, It can be stated that garlic is may be recommended to be sufficiently included in the diets of radiotherapy patients considering its antioxidant and antimicrobial efficacy.Öğe Phenolic Compounds and Antimicrobial Activity of Inula sarana Boiss(Georg Thieme Verlag Kg, 2013) Ozhan, O.; Gokbulut, A.; Gunal, S.; Sarer, E.[Abstract Not Available]Öğe The vaginal microbiota composition of women undergoing assisted reproduction: a prospective cohort study(Wiley, 2021) Karaer, A.; Dogan, B.; Gunal, S.; Tuncay, G.; Duz, S. Arda; Unver, T.; Tecellioglu, N.Objective To evaluate the impact of vaginal microbiota on pregnancy outcomes in women undergoing assisted reproduction. Design A prospective cohort study. Setting A university-based assisted reproductive technology (ART) centre. Population 223 women undergoing ART treatment. Methods Prior to embryo transfer, vaginal samples were collected from the posterior fornix. Vaginal microbiota identification was carried out using next-generation sequencing and categorised according to the V3-V4 hypervariable region in the 16S rRNA gene region. Main outcome measures ART clinical outcomes (implantation, clinical pregnancy rates and live birth rates). Results The live birth rate in women with community state type (CST)-I (39%) was higher than that in women with CST-III (21.5%) but the difference was not statistically significant (P = 0.052). The relative abundance of Lactobacillus was lower in women who failed to become pregnant (NP group) (67.71%) than in women who became pregnant (PR group) (79.72%). However, this difference was not statistically significant (P = 0.06). In the NP group, the relative abundance of Streptococcus (7.81%) and Gardnerella (9.40%) was higher than that in the PR group (relative abundance of Streptococcus and Gardnerella was 2.28% and 5.56%, respectively). The abundance of Streptococcus was found to be statistically significantly different between the two study groups (P = 0.014). Linear discriminant analysis (LDA) further validated that Streptococcus had the highest contribution (LDA score >4.0) to the difference between these two groups. Conclusions Streptococcus has the highest contribution to the distinction between the PR and NP groups. Tweetable abstract A relatively high abundance of Streptococcus in the vaginal microbiota may be associated with a lower ART success rate.
