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    Evaluation of periostin levels in gingival crevicular fluid and peri-implant sulcus fluid in patients with periodontal and peri-implanter disease: A cross-sectional study
    (2019) Uzunkaya, Meral; Gundogar, Hasan
    Aim: Periodontal and peri-implanter diseases are chronic, infectious and inflammatory diseases that manifest as a result of the relationship between their primary etiologic factor, i.e. microbial dental plaque, and the host defense system. Periostin is a protein that has been shown to play a functional role in wound repair, cardiovascular diseases, bone and tooth regeneration and tooth morphogenesis. In this study, the aim was to understand the role of periostin in periodontal (Gingivitis and Periodontitis) and peri-implant (Peri-implant mucositis and Peri-implantitis) disease.Material and Methods: Forty-two subjects were enrolled in this cross-sectional study. In the clinical measurements, PPD, GI and PI values were measured from the implants and natural teeth. Peri-implant sulcus and gingival crevicular fluids were collected from the patients using paper strips. Periostin levels were measured using ELISA. All parameter was statistically tested by using third party software (SPSS v24.)Results: In terms of PPD, there was a statistically significant difference between the gingivitis-periodontitis, gingivitis-peri-implantitis, peri-implant mucositis-periodontitis and peri-implant mucositis-peri-implantitis groups. There was a statistically significant difference between the gingivitis-periodontitis, gingivitis-peri-implantitis and peri-implant mucositis-peri-implantitis groups in terms of GCF/PISF volume. Although there was no statistically significant difference between the groups in terms of the amount of GCF/PISF periostin, periostin values were higher in peri-implant mucositis and gingivitis samples as compared to the peri-implantitis and periodontitis groups.Conclusion: Clinical parameters are a valid diagnostic tool for peri-implanter disease; there is a need for multicenter studies to understand the inflammatory basis of peri-implanter diseases that are biochemically prospective.Keywords: Periodontitis; periostin; peri-implantitis; peri-implanter mucositis, gingivitis.
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    Knowledge and awareness about oral cancer among dental patients in Southeastern Anatolia
    (2020) Gundogar, Hasan; Yalcin, Eda Didem
    Aim: The aim of this study is to assess the levels of knowledge and awareness of dental patients in South-Eastern Anatolian on oral cancer.Material and Methods: This study conducted with 389 (209 females and 180 males) participants. Sociodemographic information such as age, gender, education level, living place, smoking and alcohol use were obtained from dental patients. A questionnaire including early signs and risk factors related to the disease to assess the knowledge and awareness about oral cancer was performed. Obtained data were statistically analyzed with descriptive analyses, independent t sample test and ANOVA.Results: Only 23.1% of participants had heard of oral cancer. Smoking (95.5%), alcohol (68.7%) and tobacco use (67.9%) were the most often identified risk factors of oral cancer, whereas heavy sun exposure (12.1%) was the least defined factor. There was a statistically significant difference between education level and living place for awareness of oral cancer (p 0.05). As the source of the information for oral cancer, the television and internet were the first while the medical doctors were the last.Conclusion: This study demonstrated that knowledge and awareness about the oral cancer were insufficient in South-Eastern Anatolian. There is a substantial need to raise awareness of oral cancer, its risk factors, and early signs of the disease. Visual media, billboards and information leaflets may be useful for this issue.
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    Salivary cortisol and total antioxidant capacity levels of children with untreated dental caries
    (2020) Keskin, Gul; Ucar Gundogar, Zubeyde; Ozdogru, Hakan; Ulusal, Hasan; Gundogar, Hasan
    Aim: The study aimed to evaluate the relationship between the caries frequency, which was determined using different caries indexes and biological parameters such as salivary cortisol and total antioxidant capacity (TAC).Materials and Methods: 140 patients between the ages of 5-13 without systemic disease were included in the study. Saliva samples were collected from patients whose DMFT (dmft) and PUFA (pufa) indexes were recorded, and these samples were centrifuged at 5,000 rpm for 10 minutes. All samples were stored at -20 °C until measurement. Saliva cortisol and TAC levels were measured using the ELISA kit. All data were analyzed with SPSS v.22.Results: The mean DMFT/dmft and PUFA/pufa values were estimated as 6.72±4.37, 1.39±2.08, respectively. There was no significant correlation between caries indexes and biochemical parameters.However, there was a correlation between TAC and cortisol levels in saliva. Conclusion: Within the limitations of this study, it was determined that high risk of caries in patients could not affect salivary cortisol and TAC levels; however, there was a positive correlation between salivary cortisol and TAC levels. Further studies are needed to better understand the background of the pathophysiological changes in these biochemical parameters and their relationship with caries.