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    Detecting the presence of inflammation in fibromyalgia syndrome with neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume
    (2021) Guntel, Murat; Uysal, Alper
    Aim: Our purpose was to determine the presence of inflammation in Fibromyalgia Syndrome (FMS), whether the parameters of neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) and mean platelet volume (MPV) can be used as inflammation markers.Materials and Methods: FMS patients who applied to Hatay State Hospital Physical Medicine and Rehabilitation Clinic in the last two years were analyzed retrospectively from the patient records. 92 participants were enrolled in the study, 43 of them were FMS patients, and 49 were healthy control group. Hemogram, glucose levels, hepatic panel and renal function tests, thyroid and parathyroid function testing, vitamin B12 and 25-hydroxyvitamin D, serum iron panel, folate, lipid panel, erythrocyte sedimentation rate (ESR), C-reactive protein, RF, Bucella agglutination test results were evaluated. Thus, patients with diseases that could affect NLR, PLR, and MPV were not enrolled in the study.Results: No significant difference between the groups in terms of gender distribution was found (p = 0.999). No significant difference between the groups in terms of age was found (p=0.327). When the groups were compared in terms of MPV, the values were found to be lower in the FMS group. Statistically significant difference was not found in both groups in terms of NLR, PLR, White blood count (WBC) and Platelet (PLT) levels (p=0.106; p=0.710; p=0.271; p=0.141, respectively).Conclusion: A significant difference was not found in both groups in terms of NLR and PLR, which were thought to be inflammation markers. The statistically significant higher values of mean ESR values in the FMS group indicate that inflammation may be present in the pathogenesis of FMS, but NLR and PLR cannot be used as indicators of inflammation, so correlating these rates with the severity of symptoms would be meaningless.
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    The effect of initial complaints and third year MRI lesion load on EDSS of multiple sclerosis patients
    (2021) Guntel, Murat; Duman, Taskin; Demetgul, Ozcan
    Aim: We aimed to investigate the effect of initial complaints and third-year MRI lesion burden on Expanded Disability Status Scale (EDSS) of Multiple Sclerosis Patients.Materials and Methods: Patients who were admitted to the Mustafa Kemal University Faculty of Medicine Neurology clinic and diagnosed with Multiple Sclerosis according to Mc Donald diagnostic criteria were included in the study. The initial symptoms of patients, MRI lesion burden at the end of the third year, and the EDSS score were recorded retrospectively from the patient files. 74.5 % of the participants were female and 25.5 % were male. The most common initial symptoms were: Sensory symptoms, vision symptoms, pyramidal tract symptoms, and polysymptomatic. The mean age of the patients was 33.4. Mean EDSS was found to be 1.8±1.3. The total number of lesions in the brain was 14.8 ± 4.83 on average.Results: If patients compared according to the initial symptoms at the end of the third year, the highest EDSS score was at the polysymptomatic onset group, the second-highest score was at the motor onset group. The patients with the initial symptoms of motor or polysymptomatic group had a higher mean EDSS score than the patients with the initial symptoms of vision, sensorial symptoms, or cranial neuropathy. When we examine the relationship between MRI lesion load at the end of the third year and the EDSS score, there is a strong positive correlation between them. Patients who have more lesions in the brain on MRI studies have higher average EDSS scores than patients who have fewer lesions in the brain.Conclusion: We found that the initial symptoms are directly related to the third-year EDSS score and the prognosis of the disease. We found that there was a significant relationship between the number of lesions in the brain on MRI studies at the end of the third year and the mean EDSS score.
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    Relationship of vitamin D level, fasting blood sugar, and body mass index, to carpal tunnel syndrome severity
    (2021) Guntel, Murat; Uysal, Ayhan
    Aim: This study aims to investigate the relationship between Idiopathic Carpal Tunnel Syndrome (CTS) and Vitamin D Level, Body Mass Index (BMI), and Fasting Blood Sugar.Materials and Methods: 54 CTS patients diagnosed electrophysiologically were included in the study. These patients' ages, genders, height and body weights, and body mass index values were recorded. Laboratory tests including vitamin D levels and fasting blood sugars were performed for each participant. The CTS stage was determined electrophysiologically and the Boston questionnaire and the visual analogue scale (VAS) were filled to assess total pain scores, symptom severities (CNS), and functional states (FSS).Results: There was a statistically significant difference between the distribution of CTS stages in female patients and male patients (p = 0.008). There was no statistically significant difference between mild, moderate, and severe CTS stages in terms of age, body mass index, and fasting blood glucose (p = 0.459; p = 0.232; p = 0.413, respectively). There is a statistically significant difference between CTS stages in terms of vitamin D levels (p0.001). Vitamin D averages were observed to decline from mild to severe stages of CTS. According to the Boston Carpal Tunnel Syndrome functional status scale, it was determined that there is marginal statistical significance between the stages of CTS. It was observed that the mean functional status scale scores increased from the mild stage to the severe stage (p = 0.055). There was no statistically significant difference between mild, moderate, and severe CTS stages in terms of VAS pain and paresthesia scores and the Boston Carpal Tunnel Syndrome symptom severity scale (p = 0.340; p = 0.359; p = 0.250, respectively).Conclusion: We found a significant relationship between the vitamin D level and the CTS stage. According to Boston Carpal Tunnel Syndrome Questionnaire, we found that there is a marginal statistical significance between the stages of CTS.