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    Effects of Grape Seed Extract on Diabetic Neuropathy in Mice
    (Wiley-Blackwell, 2015) Yurt, Aysegul; Koksal, Burcu; Gurbuz, Perihan; Yildiz, Azibe; Vardi, Nigar; Alcin, Ergul
    [Abstract Not Available]
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    Effects of noopept on cognitive functions and pubertal process in rats with diabetes
    (Pergamon-Elsevier Science Ltd, 2019) Gurbuz, Perihan; Duzova, Halil; Yildiz, Azibe; Cakan, Pinar; Kaya, Gul Busra; Bag, Harika Gozde Gozukara; Durhan, Merve
    Aim: Type 1 diabetes (T1DM) is a common chronic disease in childhood. Increasing insulin resistance in puberty gives rise to higher doses of insulin usage in treatment. Of this reason new approaches in treatment are needed. Noopept researches suggest it to have anti-diabetic properties. We tried to determine the effects of noopept on pubertal diabetes. Main method: The research was made with 60 prepubertal, 28 day-old, male, Sprague Dawley rats. The rats were divided into randomised 6 groups (n = 10/group). i) Control, ii) Diabetes Control, iii) Noopept Control, iv) Diabetes + Noopept, v) Diabetes + Insulin, vi) Diabetes + Insulin + Noopept. T1DM model was induced by streptozotocin on postnatal 28th day. 0.5 mg/kg noopept and 1 IU insulin were administered intraperitoneally for 14 days. Blood glucose and body weight measurements, puberty follow-up and MWM tests were performed. Hippocampus, hypothalamus and testis were evaluated histologically. Hypothalamic GnRH and kisspeptin were studied immunohistochemically. Serum LH, FSH and insulin, hippocampal homogenate NGF and BDNF levels were determined by ELISA. Key findings: Delayed puberty was normalized by noopept (p < 0.05). Blood glucose levels were lower in noopept-administered diabetic groups (p < 0.05). Noopept decreased HOMA-IR in insulin administered diabetic group (p < 0.05). Number of degenerated cells in hippocampus and testis were higher in diabetes control group when compared with other groups (p < 0.05). GnRH immunoreactivity in Diabetes + Noopept group was increased when compared to insulin + noopept group (p = 0.018). There was no difference in kisspeptin, serum LH, FSH, hippocampal NGF-BDNF levels and spatial learning assessment among groups (p > 0.05). Significance: Noopept may have positive effect in treatment of pubertal diabetes.
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    Effects of Noopept on Eye and Kidney in Prepubertal Rats with Streptozotocin-induced Diabetes
    (Wiley, 2018) Gurbuz, Perihan; Duzova, Halil; Gul, Cemile Ceren; Taslidere, Asli Cetin
    [Abstract Not Available]
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    Effects of Noopept on Hippocampal NGF and BDNF Levels and Cognitive Functions of Prepubertal Rats with Streptozotocin-Induced Diabetes
    (Karger, 2018) Gurbuz, Perihan; Duzova, Halil; Kaya, Gul Busra; Cakan, Pinar; Durhan, Merve
    [Abstract Not Available]
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    Effects of noopept on ocular, pancreatic and renal histopathology in streptozotocin induced prepubertal diabetic rats
    (Taylor & Francis Ltd, 2023) Gurbuz, Perihan; Duzova, Halil; Taslidere, Asli Cetin; Gul, Cemile Ceren
    Diabetes mellitus (DM) is a chronic disease at all ages including childhood and puberty. Failure to treat DM can cause retinopathy, nephropathy and neuropathy. Endocrine and metabolic changes during the pubertal period complicate management of DM. Noopept is a cognitive enhancer that exhibits antidiabetic properties. We investigated the effect of noopept on the histopathology of the cornea, retina, kidney and pancreas in pubertal diabetic rats. We allocated 60 prepubertal male rats randomly into six groups of 10: untreated control (C), DM control (DC), noopept control (NC), DM + noopept (D + N), DM + insulin (D + I) and DM + insulin + noopept (D + I + N). DM was induced by streptozotocin in the DC, D + N, D + I and D + I + N groups. Noopept was administered to the NC, D + N and D + I + N groups; insulin was administered to the D + I and D + I + N groups for 14 days. On day 18 of the experiment, animals were sacrificed and eyes, kidneys and pancreata were excised for histological investigation. Renal tubule diameter and corneal and retinal thickness were increased significantly in DC groups compared to the control group. The D + I, D + N and D + I + N groups exhibited fewer DM induced pathological changes than the DC group. The D + I + N group exhibited no significant differences in renal tubule diameter and corneal and retinal thickness compared to the DC group. Our findings suggest that noopept is protective against DM end organ complications in streptozotocin induced diabetic pubertal rats.
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    Effects of Noopept on Oxidative Stress Related Parameters in the Streptozotocin-Induced Diabetes Model
    (Wiley, 2022) Gurbuz, Perihan; Duzova, Halil; Kayhan, Basak; Cig, Bilal; Naziroglu, Mustafa; Akatli, Ayse Nur
    [Abstract Not Available]
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    Effects of Noopept on Pubertal Process in Streptozosin-induced Diabetic Prepubertal Rats
    (Wiley, 2017) Gurbuz, Perihan; Duzova, Halil; Yildiz, Azibe; Kaya, Gul Busra; Bag, Harika Gozukara; Taslidere, Asli Cetin; Gul, Ceren
    [Abstract Not Available]
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    Noopept Attenuates Diabetes-Mediated Neuropathic Pain and Oxidative Hippocampal Neurotoxicity via Inhibition of TRPV1 Channel in Rats
    (Springer, 2021) Duzova, Halil; Naziroglu, Mustafa; Cig, Bilal; Gurbuz, Perihan; Akatli, Ayse Nur
    Neuropathic pain and oxidative neurotoxicity are two adverse main actions of diabetes mellitus (DM). The expression levels of calcium ion (Ca2+) permeable TRPV1 channels are high in the dorsal root ganglion (DRGs) and hippocampus (HIPPO). TRPV1 is activated by capsaicin and reactive free oxygen radicals (fROS) to mediate peripheral neuropathy and neurotoxicity. Noopept (NP) acted several protective antioxidant actions against oxidative neurotoxicity. As DM is known to increase the levels of fROS, the protective roles of antioxidant NP were evaluated on the DM-mediated neurotoxicity and neuropathic pain via the modulation of TRPV1 in rats. Thirty-six rats were equally divided into control, NP, DM (streptozotocin, STZ), and STZ + NP groups. A decrease on the STZ-mediated increase of neuropathic pain (via the analyses of Von Frey and hot plate) and blood glucose level was observed by the treatment of NP. A protective role of NP via downregulation of TRPV1 activity on the STZ-induced increase of apoptosis, mitochondrial fROS, lipid peroxidation, caspase -3 (CASP-3), caspase -9 (CASP-9), TRPV1 current density, glutathione (GSH), cytosolic free Zn2+, and Ca2+ concentrations in the DRGs and HIPPO was also observed. The STZ-mediated decrease of glutathione peroxidase, GSH, vitamin E, and beta-carotene concentrations in the brain cortex, erythrocyte, liver, kidney, and plasma was also attenuated by the treatment of NP. The STZ-mediated increase of TRPV1, CASP-3, and CASP-9 expressions was decreased in the DRGs and HIPPO by the treatment of NP. In conclusion, the treatment of NP induced protective effects against STZ-induced adverse peripheral pain and HIPPO oxidative neurotoxicity. These effects might attribute to the potent antioxidant property of NP.