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Öğe Beneficial effects of hesperidin following cis-diamminedichloroplatinum-induced damage in heart of rats(Wolters Kluwer Medknow Publications, 2016) Oguzturk, H.; Ciftci, O.; Cetin, A.; Kaya, K.; Disli, O. M.; Turtay, M. G.; Gurbuz, S.Background: Increased oxidative stress and histopathological damage have been implicated in the cardiotoxicity that limits the clinical therapy of cisplatin (CP) as an anti-cancer drug. Objectives: This study aimed to investigate the protective effect of hesperidin (HP) against CP-induced cardiotoxicity in rats. Materials and Methods: Rats were divided into four groups (n = 7/group), and the first group served as the control group. Animals in Group CP and Group CP + HP received a single dose of CP (CP - 7 mg/kg); animals in Group HP and Group CP + HP received 50 mg/kg/day HP with gavage for 14 days. At the end of day 14, cardiac tissue samples were histologically and biochemically examined. Results: In this experimental study, thiobarbituric acid reactive substances levels in the cardiac tissue were significantly higher in the CP group, whereas glutathione (GSH), superoxide dismutase (SOD), and CAT levels were significantly lower in this group. On the other hand, GSH and SOD levels in the CP + HP group were similar to the control group. There was no significant difference in cardiac CAT levels between Group CP and Group CP + HP. Conclusion: Hesperetin treatment leads to a decrease in oxidative stress, and associated histological damage. The findings of the current study suggest that HP has a protective effect against CP-induced cardiotoxicity.Öğe Curcumin protects against testis-specific side effects of irinotecan(Verduci Publisher, 2021) Uyanik, O.; Gurbuz, S.; Ciftci, O.; Oguzturk, H.; Aydin, M.; Cetin, A.; Basak, N.OBJECTIVE: Irinotecan (IR/CPT-11) is a semisynthetic, water-soluble derivative of the alkaloid camptothecin. It is a topoisomerase I group antineoplastic drug commonly used for the treatment of many cancer types, although it has side effects in tissues such as the testis. Curcumin (CRC) is a polyphenol compound produced from the Indian saffron root; it is used as food colouring and food flavouring. This study examined the testis-specific side effects of IR and the ability of CRC to protect against these side effects. MATERIALS AND METHODS: Forty male Sprague-Dawley rats were used in our study (n = 10). The rats were randomly divided into the following four groups: control, IR, IR + CRC, and CRC. IR 10 mg/kg/day was administered intraperitoneally and CRC 100 mg/kg was administered orally. Blood and testicular samples were collected from rats in all four groups on day 30 after drug administration. Histological, biochemical, and spermatological analyses were conducted. RESULTS: Testis tissue and blood samples were collected from the four groups. Tissue samples from the control and CRC groups demonstrated normal histological appearance on light microscopy. The IR group exhibited the following findings: vascular congestion in the tunica albuginea layer; tubular degeneration and vascular congestion in the interstitial area; oedema, vacuolisation, and luminised cells in the seminiferous tubule: and cells that temporarily stopped dividing at any stage of division in the seminiferous tubule epithelium. In the IR+CRC group, histopathological damage was significantly reduced by CRC treatment. Biochemical analysis showed that the level of thiobarbituric acid reactive substance (TBARS) was significantly increased in the IR group, compared with the other groups. CRC treatment significantly decreased this IR-mediated increase in TBARS level, and the TBARS level in the IR + CRC group approached the level observed in the control group. IR treatment caused significant decreases in glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) levels. However, CRC administration tended to ameliorate the decreases in GSH, SOD, CAT, and GPx levels. CONCLUSIONS: In this study, IR had some toxic effects in rat testis tissue: these effects were ameliorated by CRC treatment. Further studies are warranted to confirm our results.Öğe The effects of iron deficiency on blood transfusion requirements in traumatic brain injury(Scientific Publishers India, 2016) Durak, M. A.; Aydogan, M. S.; Gurbuz, S.Introduction: Traumatic brain injury (TBI) is the leading cause of preventable death in trauma patients. TBI often need blood transfusion, iron deficiency (ID) is known as the first cause of anemia worldwide, but no known predictors of transfusion requirements are available at intensive care unit (ICU). The aims of this study were to investigate ID relationship with blood transfusion requirements in TBI patients at ICU. Methods: One hundred forty-two patients with severe TBI, as defined by Glasgow Coma Scale (GCS) scores < 8 with an expected ICU length of stay >= 48 hours were admitted to the general ICU were enrolled in the prospective observational study between April 1, 2013, and December 31, 2015. Patients were divided into 2 groups according to their baseline iron status: iron-deficient (ID) and non-ID (normal iron profile) cohorts. Demographic features, laboratory values, blood transfusions, and length of ICU stay were recorded. Results: A total of 134 patients were included in this analysis. The mean Glasgow coma score at baseline was 6 +/- 5 and Injury Severity Score (ISS) 18.5 +/- 4.5. ID with TBI patients, which was diagnosed in 65 patients (48.5%), compared with non-ID patients, with higher ISS but no difference in admission GCS score or APACHE II scores. ID was associated with a greater use of blood transfusions (5 and 2 U/patient, respectively; p=.0001). The median length of ICU stay after TBI was longer among the ID versus the non-ID group (25 and 17 days per patient, respectively; p=.0001). Conclusion: We found that ID was highly prevalent at ICU admission patients with TBI and that it was associated with higher blood transfusion requirements. Therefore, ID may be a prognostic factor for the blood transfusion requirements in TBI at ICU.Öğe Nutritional evaluation of non-traumatic patients admitted to the hospital from Emergency Department(Verduci Publisher, 2022) Gurbuz, S.; Ekmekyapar, M.; Durak, M. A.; Oguzturk, H.; Turtay, M. G.; Yucel, N.; Demir, T. O.OBJECTIVE: Malnutrition is a common condition, especially among hospitalized patients which are overlooked by many clinicians. Malnutrition was found to be associated with increased hospitalization duration, increased admission frequency. increase in infection frequency and severity, bad wound healing, gait disturbances, fallings. and fractures. In this study, we aimed to determine malnutrition frequency in patients who were admitted to the emergency department for non-trauma causes and hospitalized. PATIENTS AND METHODS: 245 patients were admitted to the Emergency Department for non-trauma causes and hospitalized and 245 control group patients were included in this study. Hospitalized patients were assessed with NRS-2002 (Nutritional Risk Screening) and Mini Nutritional Assessment (MNA). Age, gender. height. weight, body mass index (BMI), malnutrition status. and wards of the patients were screened. RESULTS: 140 (57.1%) of the hospitalized patients had malnutrition according to NRS-2002 and MNA. There was a statistically significant difference between the control group and the hospitalized patients who were malnourished (Pearson chi-square test: p<0,001). There was a significant relation between hospitalized departments and malnutrition (p<0.05). There was a significant difference in age and height between hospitalized patients and the control group (p<0.0001) whereas no significant difference was found between the height and BMI (p>0.05). There was a significant relationship in terms of hospitalization and malnutrition. CONCLUSIONS: The nutritional state of the patients admitted to the emergency department for non-trauma conditions is an important factor and should not be overlooked.
