Yazar "Gurbuzd, Nevin" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    Activity of Benzimidazole Derivatives and their N-Heterocyclic Carbene Silver Complexes Against Leishmania major Promastigotes and Amastigotes
    (Amg Transcend Assoc, 2023) Khan, Tariq A.; Mnasri, Aziza; Al Nasr, Ibrahim S.; Ozdemir, Ismail; Gurbuzd, Nevin; Hamdi, Naceur; Biersack, Bernhard
    Little progress was conducted concerning discovering new efficient antileishmanial drugs for many years. Hence, the disease has become a global health problem meanwhile. Benzimidazole derivatives and heavy metal complexes have shown potent antiparasitic activities. The present work is intended to evaluate fourteen synthetic benzimidazolium salts and N-heterocyclic silver carbene complexes against Leishmania major. Promastigotes and amastigotes of L. major were cultured in vitro to evaluate compound-induced inhibitory effects, and isolated mouse macrophages were used for cytotoxicity evaluation. Reactive oxygen species (ROS) formation was detected for all compounds as a possible mode of action. The silver complexes 3d and 3e revealed significant activity against L. major promastigotes with IC50 values of 6.4 and 5.5 mu g mL(-1), and SI of 1.77 and 2.02, respectively. Both complexes showed higher ROS production in promastigotes than in macrophages. Further in vivo and enzyme inhibition studies are recommended to evaluate the potential of these compounds as new antileishmanial.
  • Küçük Resim Yok
    Öğe
    Synthesis, characterization, biological determination and catalytic evaluation of ruthenium(ii) complexes bearing benzimidazole-based NHC ligands in transfer hydrogenation catalysis
    (Royal Soc Chemistry, 2020) Slimani, Ichraf; Chakchouk-Mtibaa, A.; Mansour, L.; Mellouli, L.; Ozdemir, I; Gurbuzd, Nevin; Hamdi, Naceur
    A new series of ruthenium(ii) N-heterocyclic carbene complexes has been synthesized via transmetalation. These complexes are easily handled in very good yields via synthesis of silver-NHC complexes and subsequent reaction with [RuCl2(p-cymene)](2) in dichloromethane (DCM) under argon atmosphere. The new ruthenium(ii)-NHC complexes were applied to transfer hydrogenation of ketone derivatives using 2-propanol as a hydrogen source and KOH as a co-catalyst. The results show that the corresponding alcohols could be obtained in good yield with high catalyst activity (up to 76%) under mild conditions. All new compounds were characterized by spectroscopic and analytical methods. The antibacterial activities of the corresponding ruthenium(ii)-NHC complexes 4a-i were tested against positive and negative bacteria using the agar dilution procedure and their IC50 values have been determined. A cytotoxicity study of the ruthenium(ii)-NHC complexes 4 was performed against the two human cancer cell lines MDA-MB-231 and MCF-7. In addition, the scavenging activity of the synthesized complexes for the DPPH radical was also determined.