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Orta ve yüksek malignité eğilimli tedavi edilmemiş non-Hodgkin lenfomalarda MİNE protokolü uygulaması
(İnönü Üniversitesi Tıp Fakültesi Dergisi, 1997) Aydoğdu, İsmet; Koç, Haluk; İlhan, Osman; Gurman, Gunhan; Akan, Hamdi; Beksan, Meral; Konuk, Nahide; Uysal, Akin
In recent years, more effective and less toxic treatment protocols have been developed to rise cure rates in intermediate and high grade non-Hodgkin's lymphoma (NHL). This study was undertaken to investigate the efficacy and toxicity of MINE (ifosfamide, mesna, mitoxantrone and etoposide) combination chemotherapy in patients with intermediate and high grade non-Hodgkin's lymphoma. Twenty-one patients (16 male, 5 female; aged between 26 and 70 years) with non-Hodgkin's lymphoma were included in the study. An overall response rate of 73% and complete response rate of 56% were achieved and survival rate for responding patients was 80% at 48th month. Side effects including mild myelosuppression, nausea- vomiting, and alopecia were observed. MINE combination seems to be effective and well tolerated without significant toxicity as a first-line therapy in patients with intermediate or high grade NHL.