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Öğe Antioxidant Effect of a Dihydropyridine Calcium Antagonist Nitrendipine in Streptozotocin-Induced Diabetes(Pleiades Publishing Inc, 2020) Unuvar, S.; Gursoy, S.; Berk, A.; Kaymaz, B.; Ilhan, N.; Aktay, G.The present study aims to evaluate the effects of a dihydropyridine (DHP) derivative calcium channel antagonist nitrendipine (NIT) on lipid peroxidation (LPO), liver enzyme markers, glucose and lipid profile in rats with streptozotocin (STZ)-induced diabetes. A total of 24 female Sprague Dawley rats were classified into three groups as controls, STZ and STZ+NIT. Fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC) and high-density lipoprotein (HDL) levels, and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity were measured seven weeks after the administration of STZ and NIT. The levels of thiobarbituric acid substance (TBARS), glutathione (GSH) and total thiol content (T-SH), as well as the levels of nitric oxide and metabolites (NO, nitrate, nitrite), were evaluated to assess the level of lipid peroxidation in liver, brain, kidney, heart and eye tissues. STZ significantly increased FBG levels, ALT and AST activity, and TBARS levels (p < 0.001, for all), and significantly reduced the levels of GSH and T-SH (p < 0.05), as well as total NO and nitrate (p < 0.001). STZ triggered LPO in tissues, while simultaneously causing a marked decrease in endogenous antioxidant content. NIT administration protect the kidney (p < 0.05), heart (p < 0.01), brain (p < 0.001) and eye (p < 0.05) tissues from LPO, and also normalized the elevated FBG levels and the activity of ALT and AST (p < 0.001, for all). NIT further stimulated GSH and T-SH production, particularly in the liver, kidney and heart tissues. The results of the present study suggest that NIT shows hypoglycemic activity in STZ-DM rats by increasing insulin sensitivity in the peripheral target tissues.Öğe Antioxidant Effect of a Dihydropyridine Calcium Antagonist Nitrendipine in Streptozotocin-Induced Diabetes (vol 57, pg 126, 2020)(Pleiades Publishing Inc, 2021) Unuvar, S.; Gursoy, S.; Berk, A.; Kaymaz, B.; Ilhan, N.; Aktay, G.[Abstract Not Available]Öğe The antioxidant effects of dry apricot in the various tissues of rats with induced cold restraint stress(Taylor & Francis Ltd, 2012) Uguralp, S.; Ozturk, F.; Aktay, G.; Cetin, A.; Gursoy, S.alpha-Tocopherol and beta-carotene are the best known and most widely used natural antioxidant substances. Apricot contains beta-carotene, tocopherols and flavonoids. This experimental study was designed to investigate the protective effect of Malatya kabashi apricot in stress-induced injury in various tissues of rats. In total, 32 male Wistar albino rats were divided into four groups: control, apricot, stress and apricot-stress groups. Apricot was administrated to rats by gavage for 10 days in the apricot and apricot-stress groups. Then rats were kept at 4 degrees C for 4 h in stress and apricot-stress groups. The rats were killed at the end of the experiment for biochemical and histological examinations. This study shows apricot supplementation decreased oxidative stress injury in both the stomach and intestine.Öğe The effects of Teucrium polium on ionizing radiation-induced intestinal damage in rats(Univ Catholique Louvain-Ucl, 2011) Demirel, U.; Harputluoglu, M. M. M.; Us, S. B.; Kaya, E.; Sahin, N.; Aydin, N. E.; Gursoy, S.Background and study aims : Oxidative stress plays an important role in development of intestinal injury after abdomino-pelvic radiation therapy. Teucrium poliuin (TP) is a medicinal plant which has antioxidant and anti-inflammatory properties. The aim of this study was to investigate the effect of TP on radiation-induced intestinal oxidative damage in rats. Materials and methods : Group 1 (n = 8), the control group; Group 2 (n = 8), the RAD (radiation) group in which each rat received a single whole-body 800 cGy radiation performed with a LINAC; Group 3 (n = 8), the RAD + TP group in which rats were exposed to radiation as in Group 2, followed by intragastric administration of 0.5 g/kg/daily TP extract for 7 consecutive days; and Group 4 (n = 8), the TP group, rats received only intragastric TP for 7 days. Results : Radiation led to intestinal damage, which was accompanied by an increase in intestinal thiobarbituric-acid-reactive substances (TBARS) and myeloperoxidase (MPO) levels, and a decrease in reduced glutathione (GSH) levels. Although TP significantly decreased intestinal MPO levels and inflammation scores, it neither reverted intestinal TBARS and GSH levels nor ameliorated other histological parameters of the disease. Conclusions : Our results suggest that TP reduces inflammation but does not ameliorate the increased oxidative stress conditions in radiation-induced intestinal damage in rats. (Acta gastroenterol. belg., 2011, 74, 491-496).
