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Öğe The effect of trimethazidine on mortality in an experimental acute pancreatitis model(Aves, 2020) Ergucuk, Hakan; Isik, Sevil; Iflazoglu, Nidal; Kayaalp, Cuneyt; Sarac, Mehmet; Gursul, SerdarBackground/Aims: Acute pancreatitis has a high morbidty and mortality. Its physiopathogenesis has not been enlightened up to the present. This study aims to investigate trimethazidine (antiischemic, antioxidant and cardioprotective agent) 's effects on the acute pancreatitis. Materials-Methods: In this study, four aqual groups are formed with 43 female Spraque-dawley type rats weighed between 230-300 gr (mean 265 gr). 0.9% NaCl is injected intraperitoneally after laparotomy to the Group 1 (n=6). Group 2 (n=6) is control group that without any intervention. Acute pancreatitis is formed in Group 3 (n=16) via injection of Na-taurocholate in the common bile duct. Group 4 (n=15) is being formed pancreatitis and treated with Trimetazidine. In group 4 Trimetazidine 10 mg/kg/day drugs were given, 30 minutes, 24 and 72 hours after formation of acute pancreatitis, in three equal doses by orogastric way. In all groups, the rats have been laparatomised 72 hours later under general anesthesia and pancreas tissues has been extracted and studied histopathologically. Amylase, lipase, lactate dehydrogenase, aspartate transaminase, alanine tranaminase levels in the rats serum and superoxide dismutase, catalase, glutathione, malondialdehyde, nitricoxide, protein carbonyl, glutathione peroxidase levels in the rats tissue also have been looked up. Results: Serum and tissue findings and histopathologically examination of the pancreas tissues show significant decrease in the treatment group compare to study group. Conclusion: Trimethazidine protects pancreas tissue and decreases the mortality by significantly lowering the biochemical and histopathological changes in the early stages of acute pancreatitis.Öğe The effects of mythomycin C, hylan Gf20 and honey combinations on adhesion formation in laparotomized rats(2019) Sarac, Mehmet; İflazoglu, Nidal; Ergucuk, Hakan; Gursul, Serdar; Camci, CemalettinAim: Postoperative adhesions are stil unsolved important problems. Some studies have been showed that Mitomycine, Hylan GF20 and honey can decrease adhesion formation. This study; was planned to aim to compare the adhesion formation effects of Mitomycin C with Hylan GF-20, Mitomycin C with honey and Hylan GF-20 with honey combinations in the laparotomized rats. Material and Methods: Wistar-Albino 70 malerats, weight range between 180-220 gr, divided into 7 groups. After abrasion formation in the rats’ caecum wall and in the peritoneal surface at the localization of right lower quadrant of anterior abdominal wall, Mitomycin C, Hylan GF-20 and honey combinations used and seven days after operation the abdomen was opened for examination. Results: There were statistically significant differences between control group and the study groups according to adhesion formation scala. In all groups that agents were used adhesion formation was decreased, but when the groups comparing the agents used, there was no statistically significant difference. Conclusion: Mitomycin C, Hylan GF-20 and Honey usage in the laparotomized rats decrease adhesion formation. But the combinations of these agents do not show any additional effect to decrease adhesion formation.Öğe Parameters associated with survival in patients undergoing surgical treatment due to rectal cancer(2019) Gursul, Serdar; Iflazoglu, Nidal; Karabulut, Koray; Sarac, MehmetAim: Colorectal cancer is the third most common type of cancer.Approximately 1/3 of colorectal cancers are rectum cancers. The percentage of local disease stage is 39%, and the 10-year survival rate in such patients is approximately 90%. The aim of our study was to evaluate the relationship between the clinicopathological characteristics and survival of patients with rectal cancer. Material and Methods: Patients who had undergone surgical treatment for rectal cancer in our clinic between January 2008 and December 2013 were evaluated retrospectively. The effects of clinicopathological parameters of these patients on survival were investigated. The preoperative and postoperative variables were evaluated together with survival data. Results: Of the 70 patients, 30 (43%) were females and 40 (57%) were males. The median age was 61 years (min-max = 29-87 years). Eight of the patients (6%) were operated under emergency conditions due to acute abdomen or ileus. 13 (19%) of the patients had undergone laparoscopic surgery and 57 (81%) had undergone open surgical resection. 15 patients (21%) had undergone anterior resection (AR), 51 (73%) had lower anterior resection (LAR) and 4 (6%) had abdomino-perineal resection (APR). According to pTNM staging, 6 patients (8%) were at stage-0, 7 (10%) were at stage-I, 22 (32%) were at stage-II, 26 (37%) were at stage-III, and 9 (13%) were at stage IV. Conclusion: We found that the ASA (American society of Anesthesiologists) score height, final stage of the tumor and vascular (venous) invasion associated with overall survivalÖğe Vocal cord paralysis after total thyroidectomy with ecchymosis secondary to thyroid biopsy(2019) Sarac, Mehmet; Dogan, Serhat; Gursul, Serdar
