Yazar "Gurunluoglu, Kubulay" seçeneğine göre listele

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  • Küçük Resim Yok
    Öğe
    Clear cell sarcoma of the kidney in a newborn
    (2016) Gurunluoglu, Kubulay; Uğuralp, Sema; Akpolat, Nusret; Sığırcı, Ahmet; Özgen, Ünsal
    Bu makalede, 37 haftalık, gebelik süresince herhangi bir sağlık kurumunda tıbbi takibi olmadan normal vajinal yolla doğan, doğumun ardından yenidoğan ünitesinde karnında kitle fark edilen bir erkek yenidoğan olgu sunuldu. Cerrahi olarak çıkarılan kitlenin histo-patolojik incelemesinde kitlenin böbrek kaynaklı clear cell sarkoması olduğu tesbit edildi. Olgudaki mevcut bulgular sunulup, böbreğin clear cell sarkomasının çocukluk çağı ve yenidoğan döneminde ortaya çıkışı ile ilgili literatür araştırması yapılarak bununla ilgili vakalar bildirildi. Yenidoğan döneminde böbreğin clear cell sarkomasının klinik olarak ortaya çıkış şekilleri, evresi, yönetimi ve sonuçları anlatıldı. Böbreğin clear cell sarkomasının yenidoğan döneminde oldukça nadir görülmesine rağmen ayrıcı tanıda akılda tutulması gerektiği vurgulandı.
  • Küçük Resim Yok
    Öğe
    Damaging Effects of Total Parenteral Nutrition Formula on Vascular Endothelium
    (Lippincott Williams & Wilkins, 2015) Demircan, Mehmet; Gurunluoglu, Kubulay; Karaman, Abdurrahman; Mizrak, Bulent
    Objectives: Sepsis in one of the most serious complications that can occur during total parenteral nutrition (TPN) procedures. In this experimental study, we investigated the effects of TPN, with or without lipid emulsion, on vascular endothelial damage. Methods: In total, 50 rabbits were used, divided into 5 groups of 10 each. TPN with lipids (group 1), TPN without lipids (group 2), and 0.09% saline (group 3) were given for 10 days via a central venous catheter. Group 4 received no treatment other than placement of a central venous catheter for 10 days. Group 5 was a control group. At the end of day 10, rabbits were sacrificed and tissue samples of liver, kidney, and inferior vena cava were prepared and examined by immunohistochemical methods for vascular cellular adhesion molecule (VCAM)-1 expression. Results: In tissue sections of liver, kidney, and inferior vena cava, VCAM-1 activity was increased prominently in TPN with and without lipids compared with the control group. VCAM-1 activity in the TPN with lipids group was decreased versus the TPN without lipids group (P > 0.05). Conclusions: The TPN procedure results in vascular endothelial cell damage not only in the vein where the solution is introduced but also in other parts of the vascular system. Even if it is not statistically significant, lipids in the TPN formula may decrease this endothelial cell damage, as shown by immunohistochemistry.