Yazar "Guvendi, Guven" seçeneğine göre listele

Listeleniyor 1 - 1 / 1
  • Küçük Resim
    Öğe
    Effects of exercise on netrin-1 and TNF-α levels in non-inflammatory conditions
    (2020) Kizildag, Servet; Yuksel, Oguz; Hosgorler, Ferda; Koc, Basar; Kandis, Sevim; Guvendi, Guven; Uysal, Nazan
    Aim: Exercise has been shown to increase netrin-1 expression and decrease TNF-α response in inflammatory conditions. However, the effect of exercise on netrin-1 and TNF-α levels in non-inflammatory conditions has not yet been explicated. The objective of this study was to investigate the effect of exercise on netrin-1 levels in relation to TNF-α.Material and Methods: The exercise group (n=6) consisted of 6 male Balb-c mice that were kept in cages with access to a running wheel for 6 weeks. The control group (n = 6) was kept in cages without a running wheel for the same time period. At the end of 6 weeks, both groups were sacrificed. Netrin-1 and TNF-α levels of the muscle, brain, and kidney tissues were measured.Results: Netrin-1 and TNF-α levels were not different between the two groups in all tissues. Netrin-1 and TNF-α levels were correlated in the brain, muscle, and kidney tissues of the exercise group and the muscle and kidney tissues of the control group.Conclusion: In non-inflammatory conditions netrin-1 and TNF-α levels are correlated in muscle and kidney tissues but not in brain tissues. Exercise does not affect netrin-1 and TNF-α levels of muscle and kidney tissues but induces a correlation between netrin-1 and TNF-α levels of brain tissue.