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    Coexistence of immune thrombocytopenic purpura and alopecia areata: Possible relationship
    (2021) Kose, Dogan; Solmaz, Abdullah; Guzelcicek, Ahmet; Aslan, Halil
    ITP and AA are common immune-mediated disorders in childhood. Both AA and ITP have been described with different autoimmune disorders. However, their coexistence has been reported in only a few cases in the literature. In our patient, both ITP and AA spontaneously improved within 5 months and suggesting a pathophysiological relationship. In this article, we present a case of a six-month-old boy diagnosed as ITP associated with AA.
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    Evaluation of dynamic thiol-disulfide balance in children with stage 3-5 chronic kidney disease
    (2019) Cakirca, Gokhan; Nas, Cemal; Guzelcicek, Ahmet; Yilmaz, Kenan
    Aim: We aimed to examine dynamic thiol-disulfide balance, an indicator of oxidative stress, in children with stage 3-5 chronic kidney disease (CKD).Material and Methods: Native thiol (Nt), total thiol (Tt) and disulfide (DS) levels were determined spectrophotometrically in 27 children with CKD (14 non-dialysis, 13 hemodialysis) and 40 healthy controls.Results: Albumin, Nt, Tt and DS levels were markedly lower in CKD patients than in controls. However, the DS/Nt values were not statistically significant between the two groups. When Nt, Tt, DS and DS/Nt values were adjusted for albumin levels, Tt and Nt levels were lower in CKD patients than controls. In the CKD group, Nt and Tt levels were positively correlated with the albumin and estimated glomerular filtration rate and negatively with urea and creatinine. Conclusion: According to these results, decreased Nt and Tt levels in patients with CKD stages 3–5 may be evidence of exposure to oxidative stress. Keywords: Albumin; chronic kidney disease; thiol oxidation; thiol-disulfide balance.
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    Evaluation of poisoning cases applying to pediatric emergency service unit: Retrospective study
    (2020) Guzelcicek, Ahmet
    Aim: Poisoning cases have a significant place among childhood health problems in terms of morbidity and mortality. Cases involving children younger than five years of age constitute the most common poisoning cases that are caused by accidents or injuries. In this study, we attempted to determine the possible precautions by analyzing the age distribution in childhood poisoning cases.Material and Methods: The files of poisoning cases applying to the pediatric emergency service unit of the hospital between March 2018 and March 2019 have been retrospectively analyzed. Cases have been analyzed in terms of patients’ age, sex and nationality and also in terms of causes of poisoning and pharmacological agents that cause poisoning.Results: 120 poisoning cases admitted to emergency service throughout one-year period comprised 0.4% of all (24,942) applications. 57 of the patients (47.5%) were female while 63 (52.5%) were male. The youngest of the patients was 0-year-old and the oldest was 17 years old and the average age of the patients was 5.2±5.5. Poisoning cases were most frequently seen (70,8%) in children in 0-5 age range and male patients comprised the majority of them. The most common cause of poisoning was paracetamol and antipyretic type of medicines. Others were organophosphate (19.4%), rat poison (12.9%) and other substances (antipsychotics, antibiotics and vitamins) (8.1%) and caustic substances (6.7%). Conclusion: Most of the poisoning cases were caused by medicines that were left out in the open. We think such cases can be reduced through parent education.
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    Investıgation of thiol-dısulfıde balance ın chıldren wıth pneumonıa
    (2020) Solmaz, Abdullah; Cevirgen, Busra; Koyuncu, Ismail; Guzelcicek, Ahmet
    Aim: We aimed to investigate the thiol-disulfide balance, role of oxidative stress in pneumonia and role of measurement of thiol as a new biological marker for the diagnosis of pneumonia in children with pneumonia who admitted to pediatric emergency service and general pediatric polyclinic.Material and Methods: In our study, patients between 6 months and 4 years of age, who admitted to the Pediatric Emergency Department and Pediatric Policlinic of between January 2017 and February 2018 with a diagnosis of community-acquired pneumonia, were evaluated prospectively. A total of 90 patients were included in the study, including 45 patients and 45 healthy children in the same age group. These patients were examined for age, gender, symptoms and physical examination findings, native thiol, total thiol and disulfide values. Results: There was no significant difference between the patient and control groups in terms of gender. Statistically significant difference was observed between native thiol, total thiol and disulfide values between patient and control group (p0.05). In the patient group, the levels of native thiol and total thiol were low and disulfide levels were found to be high. There was a significant difference between patient and control group in terms of disulfide / total thiol, disulfide / native thiol and native thiol / total thiol parameters (p0.05). Disulfide / total thiol and disulfide / native thiol parameters were high in the patient group. Nativethiol / total thiol ratio was found to be high in the control group. Conclusion: In children with pneumonia; native thiol, total thiol, disulfide and their ratios were found to be significantly correlated. It was found that oxidative stress has an important role in the pathogenesis of pneumonia. The use of thiols in the diagnosis of pneumonia may guide clinicians.
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    Sociodemographic characteristics and dynamic thiol/disulfide homeostasis in pediatric patients presenting with scorpion sting
    (2019) Deveci, Serhat; Demir, Mahmut; Guzelcicek, Ahmet; Kirmit, Adnan
    Aim: Poisoning from scorpion sting is an important public health problem, and may cause disability and death especially in childhood. In our study, we aimed to evaluate the sociodemographic characteristics, clinical findings, laboratory results and dynamic disulfide/thiol homeostasis as oxidative stress factor of pediatric patients presenting with scorpion sting complaints to our hospital.Material and Methods: Forty patients in the 0-18 age group who admitted to the Pediatric Emergency Outpatient Clinic due to scorpion sting intoxication were included in the patient group, and 38 healthy children in the same age group were included in the control group. Patients’ sociodemographic characteristics, clinical and laboratory findings, treatment modalities and the outcomes were examined. In addition, thiol/disulfide levels in the serums of patients were studied with a new method developed by Erel et al.Results: Forty pediatric patients (57.5% male and 42.5% female) presenting with scorpion sting complaints were included in the study. Results: There was no statistically significant difference among patient and control group with regards to the mean native thiol levels. While it was found that the levels of the total thiol, disulfide, disulfide/native thiol and disulfide/total thiol were statistically significant higher in the patient group, the native thiol/total thiol ratio was found to be lower at a significant level. Conclusion: The scorpion sting incidents are still an important health problem in Turkey. In children with scorpion sting, the thiol/disulfide homeostasis was observed to shift towards the disulfide side, i.e. to the right, indicating an increase in oxidative stress.