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    Clinical significance of pulmonary function tests in patients with acute pancreatitis
    (Springer, 2006) Ates, F; Hacievliyagil, S; Karincaoglu, M
    The aim of the present study was to investigate changes in pulmonary function tests (PFTs) in patients with acute pancreatitis (AP), to compare them with those changes in healthy controls, and to analyze the relationship between these parameters and computed tomography severity index (CTSI) and Ranson's criteria scores as markers of disease severity. This study included 40 patients with AP without a diagnosis of any pulmonary disease and 40 sex- and age-matched healthy controls. All participants were evaluated with simple PFTs and single-breath carbon monoxide (CO) diffusion tests. Patients with AP were also evaluated according to their CTSI and Ranson's criteria scores as markers of disease severity. The forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), FEV1/FVC, and peak expiratory flow, which determine lung capacity, were similar in the two groups. The forced expiratory volume during the middle half of the FVC (FEF25 - 75%), CO diffusing capacity (D-LCO), and ratio of D-LCO to alveolar ventilation (D-LCO/V-A), which determines alveolar membrane permeability, revealed a statistically significant decline in pulmonary gas exchange in patients with AP (P < 0.05). Correlation analysis showed that there is a significant negative relationship between CTSI and Ranson's criteria scores with FEF25 - 75%, D-LCO, and D-LCO/V-A (P < 0.05). We suggest that AP may cause impaired alveolar gas exchange without manifest pulmonary diseases. The effect of AP on FEF25 - 75%, D-LCO, and D-LCO/V-A appears to be dependent not only on the disease, but also on its severity. FEF25 - 75%, D-LCO, and D-LCO/V-A may give additional prognostic information in patients with AP in the initial evaluation.
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    Effect of water extract of Turkish propolis on tuberculosis infection in guinea-pigs
    (Academic Press Ltd- Elsevier Science Ltd, 2004) Yildirim, Z; Hacievliyagil, S; Kutlu, NO; Aydin, NE; Kurkcuoglu, M; Iraz, M; Durmaz, R
    Mycobacterium tuberculosis (H37Rv)-infected guinea-pig model was used to investigate the effect of water extract of propolis (WEP). After subcutaneous inoculation of tubercle bacilli, each animal received oral WEP (n = 9), isoniazid (n = 5) or saline (n = 6) as placebo and were sacrificed 30 days later. Formation of necrosis was less prominent in the group treated with WEP, but was not statistically significant (P > 0.05). The granuloma formation in the same group was more prominent than the placebo and isoniazid groups; however, this finding failed to reach statistical significance by the Kruskal-Wallis test (P > 0.05). These findings suggest that Turkish WEP may have a limited effect on the development of tuberculosis infection in this guinea-pig model. (C) 2003 Elsevier Ltd. All rights reserved.
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    Proteolytic enzyme sensitivity and decrease in respiratory function (a 10-year follow-up)
    (Springer, 2002) Kizkin, O; Suleyman, GT; Hacievliyagil, S; Gunen, H
    Objectives: In workers, sensitivity and occupational asthma are known to develop in reaction to the proteolytic enzymes used in the manufacture of detergents. This study was conducted to find out how this sensitivity to the proteolytic enzymes affects respiratory function, excluding occupational asthma. Methods: Workers in the detergent industry (n = 65) were divided into four groups according to their prick-test results, as follows: those positive for at least one enzyme (Lipolase, Savinase) (group I, n = 15); enzyme-negative cases (group II, n = 50); and from among these, enzyme-positive non-smoking cases (group Ia, n = 11); enzyme-negative non-smoking cases (group IIa, n = 32) Respiratory function tests for the last 10 years from the archives were assessed. For statistic analysis, average values were determined and the standard deviation calculated. For comparison of the groups, the Mann-Whitney U and Fischer Exact chi-square tests were used. Results: The ratio of smokers, the cigarette burden, average age and the period of work were found to be similar between workers of groups I and II, and group Ia and group IIa (P>0.05). The average annual fall in the forced vital capacity (FVC) and the forced expiratory volume in the first second (FEV1) for the 10-year period was, respectively, found to be: group I, 64.1 +/- 7.8 ml and 58.7 +/- 9.6 ml; group II, 38.7 +/- 6.4 ml and 43.7 +/- 18.2 ml; group Ia, 60.7 +/- 8.1 ml and 56.1 +/- 10.2 ml; group IIa, 37.4 +/- 6.8 ml and 42.9 +/- 8.1 ml. The decrease in FVC and FEV1 in group I compared with group II, and in group Ia compared with group IIa was statistically significant (P<0.001). Conclusions: In this study, the observation that the FVC and FEV1 of the workers were much lower than expected, especially among those sensitive to the enzymes, independently of occupational asthma and cigarette smoking, led to the conclusion that it could be due to sensitivity to the enzymes.