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    Effects of iloprost on bleomycin-induced pulmonary fibrosis in rats compared with methyl-prednisolone
    (Elsevier Doyma Sl, 2012) Aytemur, Z. Ayfer; Hacievliyagil, S. Savas; Iraz, M.; Samdanci, E.; Ozerol, E.; Kuku, I.; Nurkabulov, Z.
    Objective: Prostacyclin (PGI2) has been shown to inhibit the expression of pro-inflammatory and pro-fibrotic mediators in pulmonary fibrosis. In this study, we aimed to test the preventive effects of intraperitoneally administered iloprost, a stable PGI2 analog, on bleomycin-induced pulmonary fibrosis in rats and to compare the effects of iloprost with the effects of methylprednisolone, a traditional therapy. Methods: Rats were randomly allocated into four groups: 1. Saline alone (n = 6); 2. Bleomycin + placebo (n = 7); 3. Bleomycin + methyl-prednisolone (n = 7); 4. Bleomycin + iloprost (n = 7). Fibrotic changes in the lungs were demonstrated by analyzing the cellular composition of bronchoalveolar lavage fluid, histological evaluation and lung hydroxyproline content. Results: Fibrosis was made in the lungs of rats by bleomycin experimentally. Fibrosis scores in the methyl-prednisolone and the iloprost groups were significantly lower than in the placebo group (p < 0.05). Furthermore, the score of the iloprost group was significantly lower than the score of the methyl-prednisolone group. The hydroxyproline content was significantly less in the methyl-prednisolone and the iloprost groups (p < 0.05). In the placebo group, the neutrophil percentage in bronchoalveolar lavage was significantly higher than in the other groups, whereas the macrophage percentage in placebo group was significantly lower (p < 0.05). Conclusion: Iloprost has protective effect on the pulmonary fibrosis induced by bleomycin and it may be more effective in decreasing fibrotic changes than methyl-prednisolone. (C) 2011 Sociedade Portuguesa de Pneumologia. Published by Elsevier Espana, S. L. All rights reserved.
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    Intensive Clinic Intervention Plus Psychodrama in Smoking Cessation and Effects on Cessation Outcome
    (Ortadogu Ad Pres & Publ Co, 2012) Aytemur, Zeynep Ayfer; Pismisoglu, Bulent; Kilinc, Oguz; Pismisoglu, Emine; Hacievliyagil, S. Savas; Karaman, Canan
    Objective: Psychodrama is a therapeutic discipline, which uses action methods, role training, and group dynamics to facilitate a constructive change in the lives of participants. This study was run to assess the effectiveness of psychodrama on intensive clinic intervention for smoking cessation. Material and Methods: The process and outcome of smoking cessation program using intensive cognitive-behavioral therapy (CBT) and pharmacotherapy (PT) or CBT and PT plus psychodrama was studied on 113 participants. Sixty-one participants were randomized in CBT and PT plus psychodrama group, and 52 participants were randomised in CBT and PT group. Success rate of smoking cessation was assessed at the end of the first, third and sixth months. Results: At the end of the first and third months, the rates of smoking cessation were 80.3% and 63.9% in study group, and 59.6% and 46.2% in control group (p=0.014 and p=0.044, respectively). In the sixth month, the rate of smoking cessation was 50.8% in the study group and 38.5% in the control group (p=0.130). Conclusion: In this study, we concluded that the intensive clinic intervention plus psychodrama increased the success rate of smoking cessation in the early period.