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  • Küçük Resim Yok
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    The comparison of levobupivacaine in continuous or single dose spinal anesthesia for transurethral resection of prostate surgery
    (Elsevier Science Inc, 2014) Baydilek, Yunus; Yurtlu, Bulent Serhan; Hanci, Volkan; Ayoglu, Hilal; Okyay, Rahsan Dilek; Kayhan, Gulay Erdogan; Tokgoz, Husnu
    Background: The aim of the study is to compare the efficacy of levobupivacaine induced continuous spinal anesthesia (CSA) versus single dose spinal anesthesia (SDSA) in patients who are planned to undergo transurethral prostate resection. Methods: Sixty years or older, ASA I-II or III, 50 patients were included in the study. 12.5 mg 0.5% levobupivacaine were administered intrathecally in SDSA group. In CSA group, initially 2 mL of 0.25% levobupivacaine were administered through spinal catheter. In order to achieve sensory block level at 110 dermatome, additional 1 mL of 0.25% levobupivacaine were administered through the catheter in every 10 min. Hemodynamic parameters and block characteristics were recorded. Preoperative and postoperative blood samples of the patients were drawn to determine plasma cortisone and plasma epinephrine levels. Results: CSA technique provided better hemodynamic stability compared to SDSA technique particularly 90 min after intrathecal administration. The rise in sensory block level was rapid and the time to reach surgical anesthesia was shorter in SDSA group. Motor block developed faster in SDSA group. In CSA group, similar anesthesia level was achieved by using lower levobupivacaine dose and which was related to faster recovery. Although, both techniques were effective in preventing surgical stress respond, postoperative cortisone levels were suppressed more in SDSA group. Conclusion: CSA technique with 0.25% levobupivacaine can be used as a regional anesthesia method for elderly patients planned to have TUR-P operation. (C) 2013 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.
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    Effect of sugammadex on recovery from ketamine anesthesia: An experimental study
    (2020) Kayir, Selcuk; Dogan, Guvenc; Yagan, Ozgur; Hanci, Volkan
    Aim: Previous studies have shown cyclodextrins bind to a variety of medications. The hypothesis in our study is to determine whether or not sugammadex interacts with the lipophilic medication of ketamine to shorten the effect duration and ensure earlier recovery. Material and Methods: The study used 24 adult male Sprague-Dawley rats. Rats were randomly divided into 4 equal groups. Each rat was administered 75 mg/kg ketamine intraperitoneal (ip) bolus and then in the fifth minute rats was administered sugammadex at appropriate doses for their group through the lateral vein in the tail. Group C (control group) were administered 15 mL/kg physiologic serum (PS) (n=6), Group Sgdx 16 were administered 16 mg/kg sugammadex (n=6), Group Sgdx 100 were administered 100 mg/kg sugammadex (n=6) and Group Sgdx 1000 were administered 1000 mg/kg sugammadex (n=6). The heart rate, respiratory rate and recovery durations of the rats were recorded. Results: The recovery duration in the Sgdx 100 group was statistically significantly shorter compared to the control group (p=0.026), while the recovery duration in the Sgdx 1000 group was statistically significantly shorter than the control group (p0.001) and the Sgdx 16 group (p=0.015). Heart rate was statistically significantly low in the Sgdx 1000 group compared to the control group (p0.05). Respiratory rates were similar. Conclusion: Our study showed that 100 mg/kg and 1000 mg/kg sugammadex doses significantly shortened recovery. We conclude that there is a need for more research about the interaction between ketamine and sugammadex.