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    Epidemiology of Pemphigus in Turkey: One-year Prospective Study of 220 Cases
    (Croation Dermatovenerological Soc, 2017) Yayli, Savas; Harman, Mehmet; Baskan, Emel Bulbul; Karakas, Ayse Akman; Genc, Yeser; Turk, Bengu Gerceker; Demirsoy, Evren Odyakmaz
    Pemphigus is a group of rare and life-threatening autoimmune blistering diseases of the skin and mucous membranes. Although they occur worldwide, their incidence shows wide geographical variation, and prospective data on the epidemiology of pemphigus are very limited. Objective of this work is to evaluate the incidence and epidemiological and clinical features of patients with pemphigus in Turkey. All patients newly diagnosed with pemphigus between June 2013 and June 2014 were prospectively enrolled in 33 dermatology departments in 20 different provinces from all seven regions of Turkey. Disease parameters including demography and clinical findings were recorded. A total of 220 patients were diagnosed with pemphigus during the 1-year period, with an annual incidence of 4.7 per million people in Turkey. Patients were predominantly women, with a male to female ratio of 1:1.41. The mean age at onset was 48.9 years. Pemphigus vulgaris (PV) was the commonest clinical subtype (n= 192; 87.3%), followed by pemphigus foliaceus (n= 21; 9.6%). The most common clinical subtype of PV was the mucocutaneous type (n= 83; 43.2%). The mean Pemphigus Disease Area Index was 28.14 +/- 22.21 (mean +/- Standard Deviation). The incidence rate of pemphigus in Turkey is similar to the countries of South-East Europe, higher than those reported for the Central and Northern European countries and lower than the countries around the Mediterranean Sea and Iran. Pemphigus is more frequent in middle-aged people and is more common in women. The most frequent subtype was PV, with a 9-fold higher incidence than pemphigus foliaceus.
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    PHomatrikoma: Bir retrospektifçalışma
    (Turgut Özal Tıp Merkezi Dergisi, 2000) Uzunlar, Ali Kemal; Yılmaz, Fahri; Özaydın, Mehmet; Harman, Mehmet
    The purpose of this study is to review the clinical and histologic features of pilomatricomas diagnosed in our department. Materials and Methods: In this study, 32 patients with pilomatricoma diagnosed at Pathology Department of Dide University Medical Faculty, during the period 1984-1999 are presented. Findings: The mean age was 27.43 years and the majority of the cases occurred in the third decade of life. One of our cases was perforating pilomatricoma. Histopathologically, the most important feature of pilomatricoma was shadow cells (ghost cells). We observed that the most common sites were head, neck and upper limb. Conclusions: Pilomatricoma can be easily confused clinically with other lesions.
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    Rituximab therapy in pediatric pemphigus patients: A retrospective analysis of five Turkish patients and review of the literature
    (Wiley, 2019) Bilgic-Temel, Asli; Ozgen, Zueleyha; Harman, Mehmet; Kapicioglu, Yelda; Uzun, Soner
    Background/Objectives There is inadequate knowledge regarding rituximab (RTX) administration in autoimmune bullous diseases (AIBDs), disease prevalence, clinical characteristics, and treatment outcomes within pediatric populations due to the rarity of AIBDs affecting the pediatric age group. The aim of this retrospective analysis was to evaluate the effectiveness, safety of RTX, and treatment outcomes in Turkish pediatric patients with pemphigus vulgaris (PV) and to review the literature. Methods Five patients under 18 years of age and diagnosed with PV received RTX treatment and were identified in four dermatology departments of Turkey. Results The mean age of the patients at the time of RTX therapy initiation was 15 years (range: 11-17 years), and the total duration of follow-up after RTX therapy was 42.6 months (range: 19-60 months). All patients showed a clinical response. At the last visit, complete remission off therapy was achieved in three patients. The remaining two patients achieved partial remission off therapy. No adverse events were observed. Conclusions This retrospective case series of five pediatric patients showed that RTX treatment can be effective and safe for the treatment of recalcitrant PV in pediatric patients. With increasing evidence, RTX is a good treatment choice in adults and pediatric patients with pemphigus.