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Öğe Doppler sonography of the inferior and superior mesenteric arteries in ulcerative colitis(J Clin Ultrasound, 2001) Sığırcı, Ahmet; Baysal, Tamer; Kutlu, Ramazan; Aladağ, Murat; Saraç, Kaya; Harputluoğlu, HakanPurpose. The purpose of this study was to evaluate the Doppler sonographic blood-flow parameters and spectral patterns in the inferior mesenteric artery (IMA) and superior mesenteric artery (SMA) in patients with active and inactive (remission-phase) ulcerative colitis (UC). Methods. The IMAs and SMAs of 25 patients with active-phase UC (group 1), 19 patients with remissionphase UC (group 2), and 22 healthy, asymptomatic subjects (control group) were evaluated by duplex Doppler sonography. The 25 patients in group 1 were categorized into 2 subgroups on the basis of the extent of disease as determined by double-contrast barium enema x-ray study and colonoscopy. The first subgroup (group 1a) consisted of 11 patients with active involvement of the left colon from the rectum to the splenic flexure. The second subgroup (group 1b) consisted of 14 patients with active involvement of the entire colon. The peak systolic velocity (PSV), enddiastolic velocity (EDV), mean velocity (Vmean), resistance index (RI), and pulsatility index (PI) were determined from the Doppler spectral analysis. The inner diameter and cross-sectional area of the IMA and SMA were measured, and the blood-flow volume was calculated. The results were compared between the patient groups and control subjects. Results. In the IMA, the mean blood-flow volume, mean PSV, mean EDV, and Vmean were significantly higher, the mean PI was significantly lower, and the mean diameter and the mean cross-sectional area were significantly larger in group 1 than in group 2 or in the control group (p < 0.001). The mean PSV and the Vmean of the IMA were significantly higher in group 1a than in group 1b (p < 0.05). The mean blood-flow parameters in the SMA were not significantly different between groups 1 and 2 or between either group 1 or group 2 and the control subjects. The mean EDV in the SMA was significantly higher and the mean PI and the mean RI were significantly lower in group 1b than in group 1a (p < 0.01). Conclusions. Duplex Doppler sonography of the IMA and SMA can be used to evaluate inflammatory disease of the large bowel, to assess disease extent, and to document response to therapy.Öğe Erectile dysfunction in testicular cancer patients treated with chemotherapy(Andrologia, 2012) Taşdemir, Cemal; Fırdolaş, Fatih; Harputluoğlu, Hakan; Altıntaş, Ramazan; Güneş, AliInformation on male potency in testicular cancer (TC) patients treated with chemotherapy is insufficient. We aimed to assess the levels of depression and anxiety symptoms, sexual function and gonodotrophins. Participants (n = 27) were identified and recruited from the genitourinary services of two medical centres, one in Inonu University and the other in the Firat University. All patients are TC patients treated with chemotherapy after unilateral orchiectomy. Participants completed follow-up assessments after the completion of the chemotherapy regimen. Serum luteinising hormone, follicle-stimulating hormone and testosterone levels were determined after blood samples had been taken in the morning after an overnight fast. International Index of Erectile Function (IIEF-15) was also used to evaluate erectile dysfunction (ED) score. Beck Depression and Beck Anxiety Scale were used to assess psychological symptoms. The findings indicated that men treated with chemotherapy had significantly different IIEF-15 and Beck Anxiety scores compared with men who did not receive chemotherapy. But no statistically significant difference was determined in the serum gonodotrophin levels and depression score between the two groups. It is concluded that patients with TC undergoing chemotherapy have greater risk than normal men for ED, independently of the gonodotrophin’s level.Öğe Estimation of risk factors associated with colorectal cancer an application of knowledge discovery in databases(Kuwait journal of science, 2016) Fırat, Feyza; Arslan, Ahmet Kadir; Çolak, Cemil; Harputluoğlu, HakanColorectal cancer is one of the first reasons for death due to cancer in the world. The goal of this study is to predict important risk factors of colorectal cancer (CRC) by knowledge discovery in databases (KDD) methods. This study comprised a retrospective CRC data of patients who had been diagnosed with colorectal cancer. The selected records between 1 January 2010 and 1 March 2014 were collected randomly from Turgut Ozal Medical Centre databases. The study included 160 individuals: 80 patients admitted to Department of Oncology and diagnosed with CRC, and 80 control subjects with non-CRC categorization. The groups were matched for age and gender. We mined retrospective CRC data from large integrated health systems with electronic health records. Specific demographical and clinical variables including calcium, hemoglobin, white blood cells, platelets, potassium, sodium, glucose, creatinine and total bilirubin were used in multilayer perceptron (MLP) artificial neural networks (ANN) modeling. In this study, patient and control groups consist of 160 individuals. In each group, 45 of these (56.3%) are male, and 35 (43.7%) are women. Mean age of CRC patients and control groups is 58.6±13.0. While the accuracy was 71.31% in training dataset (n=122), the accuracy was 81.82% in testing dataset. Area under curve (AUC) values of training and testing datasets were 0.73 and 0.81, respectively. The suggested MLP ANN model identified significant factors of calcium, creatinine, potassium, platelets, sodium, hemoglobin and total bilirubin. Taken together, the suggested MLP ANN model might be used for the estimation of risk factors associated with CRC as an application of medical KDD.Öğe Estimation of risk factors associated with colorectal cancer: an application of knowledge discovery in databases(Kuwait Journal of Science, 2016) Fırat, Feyza; Arslan, Ahmet Kadir; Çolak, Cemil; Harputluoğlu, HakanColorectal cancer is one of the first reasons for death due to cancer in the world. The goal of this study is to predict important risk factors of colorectal cancer (CRC) by knowledge discovery in databases (KDD) methods. This study comprised a retrospective CRC data of patients who had been diagnosed with colorectal cancer. The selected records between 1 January 2010 and 1 March 2014 were collected randomly from Turgut Ozal Medical Centre databases. The study included 160 individuals: 80 patients admitted to Department of Oncology and diagnosed with CRC, and 80 control subjects with non-CRC categorization. The groups were matched for age and gender. We mined retrospective CRC data from large integrated health systems with electronic health records. Specific demographical and clinical variables including calcium, hemoglobin, white blood cells, platelets, potassium, sodium, glucose, creatinine and total bilirubin were used in multilayer perceptron (MLP) artificial neural networks (ANN) modeling. In this study, patient and control groups consist of 160 individuals. In each group, 45 of these (56.3%) are male, and 35 (43.7%) are women. Mean age of CRC patients and control groups is 58.6±13.0. While the accuracy was 71.31% in training dataset (n=122), the accuracy was 81.82% in testing dataset. Area under curve (AUC) values of training and testing datasets were 0.73 and 0.81, respectively. The suggested MLP ANN model identified significant factors of calcium, creatinine, potassium, platelets, sodium, hemoglobin and total bilirubin. Taken together, the suggested MLP ANN model might be used for the estimation of risk factors associated with CRC as an application of medical KDD.Öğe Gaucher hastalığı: İki olgu sunumu(Türkiye Tıp Dergisi Dahili Tıp Bilimleri, 2002) Kuku, İrfan; Kaya, Emin; Yıldız, Ramazan; Harputluoğlu, Hakan; Aydoğdu, İsmet; Gürakan, FigenÖz: Gaucher hastalığı, en sık görülen lipid depo hastalığıdır. Hastalık, otozomal resesif geçer ve lizozomal bir enzim olan ß-glikoserebrosidazi kodlayan genlerdeki mutasyonlar sonucunda ortaya çıkar. Glikoserebrosidaz eksikliği, glikoserebrosidin (glikoseramid) monosit-makrofaj sistemi hücrelerinde birikmesine neden olur. Hastalık, açıklanamayan splenomegali, pansitopeni, kemik ağrılarının ve patolojik kırıkların ayırıcı tanısında düşünülmelidir. Gaucher hastalığının Türkiye'de sıklığı bilinmemektedir. Bu makalede Tip l Gaucher hastalığı tanısı konulan 2 olgu sunuldu ve konu ile ilgili literatür gözden geçirildi.Öğe Hemodiyaliz hastalarında qt dispersiyonu ve hemodiyaliz tedavisi sırasında qt dispersiyonu değişimi(İnönü Üniversitesi, 2003) Harputluoğlu, HakanKronik böbrek yetmezliği nedeni ile hemodiyaliz tedavisi alan hastalarda kardiyovasküler problemler sık görülmektedir. Klinik ve deneysel bilgiler; QT interval dispersiyonundaki uzamamn ani kardiyak ölüm ve ventriküler aritmiler gibi geniş bir kardiyak hastalıkla ilişkili olduğunu belirtmektedir.Hemodiyaliz tedavisi sırasında ve hemodiyaliz sonrasında ventriküler aritmi insidansı arttığı bilinmektedir. Bu çalışmada herhangi birz komplikasyon olmayan hemodiyaliz seanslarında diyaliz öncesi ve sonrası QT dispersiyonu ölçüp diyaliz öncesi ve sonrası dönemde elektrolitlerde meydana gelen değişiklik ile ilişkisini araştırmak amaçlandı. Kalp yetmezliği, iskemik kalp hastalığı ve diyaliz tedavisinde hipotansiyon gelişmeyen 30 kronik böbrek yetmezliği olan hasta (16 kadın, 14 erkek, oralam yaş 44,8) çalışmaya alındı. Bütün hastalar haftada 3 kez bikarbonatlı diyalizat ve hemofan halofıber ile diyaliz tedavisi almakta idi.QT İntervali 12 kanallı EKG’ de elle ölçülüp maksimum QT, minimum QT, maksimum düzeltilmiş QT ve minimum düzeltilmiş QT ve QT dispersiyonu hesaplandı. QT c dispersiyonu ölçülen maksimum ve minimum QT c arasındaki fark hesaplanarak bulundu. EKG çekimi ile eş zamanlı olarak hastaların serum potasyum, kalsiyum sodyum, klor, BUN, kreatinin konsantrasyonları ölçüldü.Öğe Kanser ilaçlarının kardiyovasküler yan etkileri: bu yan etkiler nasıl belirlenmeli, tedavi ve takip nasıl yapılmalı?(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2011) Aktürk, Erdal; Kurtoğlu, Ertuğrul; Harputluoğlu, HakanÖz: Kanser tedavisinde yeni antikanser ilaçlarının kullanılması, erken tanı ve tedavi koşullarının değişmesi ile şifa oranı belirgin olarak artmıştır. Dolayısıyla kanser ilaçlarına maruz kalan kişi sayısı da artmıştır. Bu artış dikkate alınarak, yeni ilaçlara biraz daha vurgu yapacak şekilde antikanser ilaçların kardiyak yan etkilerini, bu yan etkilerin nasıl belirlenmesi gerektiğini, bunların tedavisinin ve takibinin nasıl olması gerektiğini değerlendirdik.Öğe Kanser ilaçlarının Kardiyovasküler Yan Etkileri: Bu Yan Etkiler Nasıl Belirlenmeli, Tedavi ve Takip Nasıl Yapılmalı?(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2011) Aktürk, Erdal; Kurtoğlu, Ertuğrul; Harputluoğlu, HakanKanser tedavisinde yeni antikanser ilaçlarının kullanılması, erken tanı ve tedavi koşullarının değişmesi ile şifa oranı belirgin olarak artmıştır. Dolayısıyla kanser ilaçlarına maruz kalan kişi sayısı da artmıştır. Bu artış dikkate alınarak, yeni ilaçlara biraz daha vurgu yapacak şekilde antikanser ilaçların kardiyak yan etkilerini, bu yan etkilerin nasıl belirlenmesi gerektiğini, bunların tedavisinin ve takibinin nasıl olması gerektiğini değerlendirdik.Öğe Prognostic markers in operated non-small cell lung cancer patients(2023) Cırık, Salih; Harputluoğlu, HakanAim: The overall survival (OS) of operable lung cancer patients is directly related to clinicopathological features and some laboratory parameters. In this study, we aimed to examine the factors affecting the survival of the operated patients. Materials and Methods: In our study, we retrospectively analyzed 202 operated-on patients diagnosed with lung carcinoma who were in stages I–IIIA at the time of diagnosis. The clinico-pathological features and some laboratory parameters of the patients included in our study were retrospectively analyzed. The effects of those parameters on the overall survival of the patients and their disease-free survival (DFS) have been investigated. Results: The age of the patient at the time of diagnosis and the presence of lymphovascular invasion (LVI) were found to be statistically significant in terms of OS (p<0.05). Pathological tumor size, LVI, and peri-neural invasion (PNI) parameters were statistically significant for DFS. In addition, neutrophil-lymphocyte ratio (NLR), which is an inflammatory indicator, is an important parameter with statistical significance in terms of both OS and DFS (p<0.05). Conclusion: Our study yielded that LVI and PNI parameters would be beneficial to estimate patients’ survival and prognosis. In addition, NLR was observed to have a statistically significant effect on OS and DFS.Öğe Sefoperazon Sodyum Kullanımına Bağlı Kanama Diyatezi(Turgut Özal Tıp Merkezi Dergisi, 2014) Doğan, Ali; Aksoy, Asude; Yıldırım, Narin; Vural, Aşkı; Harputluoğlu, Hakan; Elkıran, Emin TamerYıl: 2014Cilt: 21Sayı: 1ISSN: 1300-1744Sayfa Aralığı: 93 - 94 Metin Dili: Türkçe Öz: Başlık ( ): Bleeding Diathesis Due to Cephoperazon Sodium