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Öğe Acute liver failure in adults(Aves, 2019) Caliskan, Ali Riza; Harputluoglu, Murat[Abstract Not Available]Öğe Changing trends in the etiology of liver transplantation in Turkiye: A multicenter study(Kare Publ, 2024) Akarsu, Mesut; Dolu, Suleyman; Harputluoglu, Murat; Yilmaz, Sezai; Akyildiz, Murat; Gencdal, Genco; Polat, Kamil YalcinBackground and aim: This study aimed to identify the indications for liver transplantation (LT) based on underlying etiology and to characterize the patients who underwent LT. Materials and methods: We conducted a multicenter cross-sectional observational study across 11 tertiary centers in Turkiye from 2010 to 2020. The study included 5,080 adult patients. Results: The mean age of patients was 50.3 +/- 15.2 years, with a predominance of female patients (70%). Chronic viral hepatitis (46%) was the leading etiological factor, with Hepatitis B virus infection at 35%, followed by cryptogenic cirrhosis (24%), Hepatitis C virus infection (8%), and alcohol-related liver disease (ALD) (6%). Post-2015, there was a significant increase in both the number of liver transplants and the proportion of living donor liver transplants (p<0.001). A comparative analysis of patient characteristics before and after 2015 showed a significant decline in viral hepatitis-related LT (p<0.001), whereas fatty liver disease-related LT significantly increased (p<0.001). Conclusion: Chronic viral hepatitis continues to be the primary indication for LT in Turkiye. However, the proportions of non-alcoholic fatty liver disease (NAFLD) and ALD-related LT have seen an upward trend over the years.Öğe The Course of Endoscopic Treatment Success in Biliary Complications After Living Donor Liver Transplantation(Galenos Publ House, 2024) Ataman, Engin; Harputluoglu, Murat; Bilgic, Yilmaz; Cagin, Yasir Furkan; Erdogan, Mehmet Ali; Kutlu, Ramazan; Kutluturk, KorayObjective: Our aim was to present the results of endoscopic retrograde cholangiopancreatography (ERCP) after living donor liver transplantation (LDLT) between February 2015 and June 2021. Methods: Clinical data included LDLT indications, time to perform ERCP after LDLT, number of ERCP procedures, indications for ERCP, and all treatment outcomes, including ERCP, percutaneous, and surgical interventions. We compared the obtained data with our previous study published by our team in 2018, which included 446 patients who underwent ERCP for biliary complications after LDLT between 2005 and 2015. Results: We performed ERCP in 283 of 1506 patients with LDLT who underwent duct-to-duct anastomosis during transplantation and then developed biliary complications. Our endoscopic success rates were 60.9% and 71.0% in the previous and present studies, respectively. Conclusions: Our findings suggest that the success rate of endoscopic treatment of biliary complications in patients with LDLT increases in correlation with the increasing experience of clinicians treating these patients.Öğe Does the tumor necrosis factor a predictor factor in patients with chronic hepatitis B and C(Allied Acad, 2017) Bilgic, Yilmaz; Seckin, Yuksel; Cagin, Yasir Furkan; Yildirim, Oguzhan; Yilmaz, Cengiz; Harputluoglu, Murat; Harputluoglu, HakanAim: In our research, we aimed to investigate the importance and pattern of Tumor Necrosis Factor (TNF) alpha in response to the combinatorial treatment of lamuvidin (LAM) and Pegile interferon (PEG INF) 2a + Ribavirin (RIB) in patients with Chronic Hepatitis B (CHB) and Chronic Hepatitis C (CHC). Material and method: Thirty four CHB and 25 CHC patient samples were taken before and after the treatment and stored appropriately. CHB patients were treated with LAM and CHC patients were treated with using the combination of PEG INF 2a and RIB. HBV DNA, anti HBe, ALT, AST and TNF alpha results were obtained from CHB patients before and 48th week of the treatment. HCV RNA, ALT, AST and TNF alpha results were also obtained from CHC patients before and in the 6th month of completing the treatment. Responses to the treatment were taken as negative result of HBV DNA in CHB patients after finishing the treatment and as negative result of HCV RNA in CHC patients after 6 months of finishing the 48 weeks of PEG INF treatment. Results: At the level of decreasing TNF-alpha in CHB patients when the group responding to the treatment compared to the group not responding to the treatment, a significant difference was observed in favor of the respondent group (p< 0.0001). At the level of decreasing TNF-alpha in CHC patients when the group responding to the treatment compared to the group not responding to the treatment, a significant difference was also obtained in favor of the respondent group (p< 0.0001). In the analysis for emphasizing the importance of TNF alpha level in response to the treatment in CHB patients, it was found that predicting the response to the treatment of TNF alpha was 78.6% sensitivity and 75% specificity for 68.78 cutoff. In the analysis for emphasizing the importance of TNF alpha level in response to the treatment in CHC patients, it was found that determining the response of TNF alpha to the treatment was 100% sensitivity and 100% specificity for 122.4 cutoff. Conclusions: With the treatment a decrease in TNF alpha is occured in CHB and CHC patients; however, TNF alpha decrease in the groups responding to the treatment is more significant. The results of this research show that TNF alpha level may be an important non-invasive marker for foresight and determining the response to the treatment.Öğe Fascioliasis presenting as colon cancer liver metastasis on 18F-fluorodeoxyglucose positron emission tomography/computed tomography: A case report(Baishideng Publishing Group Inc, 2019) Akbulut, Sami; Ozdemir, Egemen; Samdanci, Emine; Unsal, Selver; Harputluoglu, Murat; Yilmaz, SezaiBACKGROUND Fascioliasis is caused by watercress and similar freshwater plants or drinking water or beverages contaminated with metacercariae. Fascioliasis can radiologically mimic many primary or metastatic liver tumors. Herein, we aimed to present the treatment process of a patient with fascioliasis mimicking colon cancer liver metastasis. CASE SUMMARY A 35-year-old woman who underwent right hemicolectomy due to cecum cancer was referred to our clinic for management of colon cancer liver metastasis. Both computed tomography and 18F-fluorodeoxyglucose positron emission tomography revealed several tumoral lesions localized in the right lobe of the liver. After a 6-course FOLFOX (folinic acid, fluorouracil, oxaliplatin) and bevacizumab regimen, the hypermetabolic state on both liver and abdominal lymph nodes continued, and chemotherapy was extended to a 12-course regimen. The patient was referred to our institute when the liver lesions were detected to be larger on dynamic liver magnetic resonance imaging 6 weeks after completion of chemotherapy. Right hepatectomy was performed, and histopathological examination was compatible with fascioliasis. Fasciola hepatica lgG enzyme-linked immunosorbent assay was positive. The patient was administered two doses of triclabendazole (10 mg/kg/dose) 24 h apart. During the follow-up period, dilatation was detected in the common bile duct, and Fasciola parasites were extracted from the common bile duct by endoscopic retrograde cholangiopancreatography (ERCP). Triclabendazole was administered to the patient after ERCP. CONCLUSION Parasitic diseases, such as those caused by Fasciola hepatica, should be kept in mind in the differential diagnosis of primary or metastatic liver tumors, such as colorectal cancer liver metastasis, in patients living in endemic areas.Öğe First year real life experience with tenofovir alafenamide fumarate: The pythagorean cohort(Kare Publ, 2023) Karasahin, Omer; Kalkan, Irem Akdemir; Dal, Tuba; Toplu, Sibel Altunisik; Harputluoglu, Murat; Mete, Ayse Ozlem; Komur, SuheylaBackground and Aim: In chronic hepatitis B infection, antiviral therapy significantly reduces the incidence of complications. This study aimed to present real-life 12-month effectiveness and safety data for TAF.Materials and Methods: This Pythagoras Retrospective Cohort Study included patients from 14 centers in Turkiye. The study presents 12-month results of 480 patients treated with TAF as initial therapy or after switching from another antiviral drug.Results: The study shows treatment of about 78.1% patients with at least one antiviral agent (90.6% tenofovir disoproxil [TDF]). The rate of undetectable HBV DNA increased in both treatment-experienced and naive patients. In TDF-experienced patients, the rate of alanine transaminase (ALT) normalization increased slightly (1.6%) within 12 months, but the change was not statistically significant (p=0.766). Younger age, low albumin, and high body mass index and cholesterol were identified as risk factors for abnormal ALT after 12 months, but no linear relationship was detected. In TDF-experienced patients, renal and bone function indicators showed significant improvement three months after the transition to TAF and remained stable for 12 months.Conclusion: Real-life data demonstrated effective virological and biochemical responses with TAF therapy. After switching to TAF treatment, gains in kidney and bone functions were achieved in the early period.Öğe HBV viral load and tumor and non-tumor factors in patients with HBV-associated HCC(Kare Publ, 2024) Ataman, Engin; Harputluoglu, Murat; Carr, Brian Irving; Gozukara, Harika; Ince, Volkan; Yilmaz, SezaiBackground and Aim: Several tumor and non-tumor factors affect the prognosis of hepatocellular carcinoma (HCC) patients. This study aimed to investigate the effects of hepatitis B virus (HBV) viral load on tumor and non-tumor factors in patients with HBV-associated HCC. Materials and Methods: Patients with hepatitis B and HCC who presented Transplantation Institute, were included in our study. Patients were divided into two groups according to the presence or absence of HBV-DNA, and it was determined whether there were differences between these two groups with respect to tumor and non-tumor parameters. Results: Comparison of serum alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), hepatitis B surface antigen (HBsAg), and C-reactive protein (CRP) levels between HBV-DNA negative and positive patients showed significant differences (respectively p<0.01, p<0.01, p<0.05, and p<0.05). A major finding was a very significant difference between the two patient groups in terms of portal vein invasion (PVI) and venous invasion (p<0.001 and p<0.01, respectively). However, there was no significant difference in metastasis or lymph node involvement between HBV-DNA negative and positive patients. Conclusion: Our findings suggest that HBV viral load plays an important role in PVI in HCC patients, and there is a significant relationship between HBV viral load and inflammation.Öğe Hepatitis B Before and After Hepatocellular Carcinoma(Springer, 2021) Harputluoglu, Murat; Carr, Brian, IHepatitis B virus (HBV) is the one of most common causes of the hepatocellular carcinoma (HCC), especially in eastern world. The aim of this review is to try to understand the relationship between HBV and HCC and to reveal the role of prevention and treatment of HBV infection in reducing the incidence of HCC. Strategies to prevent HCC due to HBV can be classified into three categories. These are primary, secondary, and tertiary preventions. Hepatitis B vaccine is now in the most vital position in preventing HBV-associated HCC. In patients with chronic hepatitis B infection, suppressing viral load with potent antivirals such as tenofovir disoproxil fumarate (TDF) and entecavir (ETV) prevents the development of HCC and improves prognosis by reducing recurrence after HCC treatments. There is currently no clear consensus on which of these drugs should be preferred. Although data on tenofovir alafenamide (TAF) are scarce, available data with TDF suggest that TAF therapy will also be a strong actor for HCC.Öğe How to Decrease Relapse of Viral Hepatitis B in Live Donor Liver Transplant Recipients?(Wiley-Blackwell, 2013) Aladag, Murat; Harputluoglu, Murat; Aladag, Hulya; Yilmaz, Sezai[Abstract Not Available]Öğe Identification of risk factors for alcohol relapse in liver transplant patients with alcohol-related liver disease(Elsevier, 2023) Turan, Dilara; Gunsar, Fulya; Harputluoglu, Murat; Kabacam, Gokhan; Gokcan, Hale; Akyildiz, Murat; Akarsu, Mesut[Abstract Not Available]Öğe Letter to the editor: Liver transplantation following severe acute respiratory syndrome-coronavirus-2 vaccination-induced liver failure(Wiley, 2022) Efe, Cumali; Harputluoglu, Murat; Soylu, Nese Karadag; Yilmaz, Sezai[Abstract Not Available]Öğe Lighter Ingestion as an Uncommon Cause of Severe Vomiting in a Schizophrenia Patient(Hindawi Ltd, 2016) Atayan, Yahya; Cagin, Yasir Furkan; Erdogan, Mehmet Ali; Bilgic, Yilmaz; Bestas, Remzi; Harputluoglu, Murat; Seckin, YukselBackground. Foreign bodies in the gastrointestinal tract are important morbid and mortal clinical conditions. Particularly, emergency treatment is required for cutting and drilling bodies. The majority of ingested foreign bodies (80-90%) leave gastrointestinal tract without creating problems. In 10-20% of cases, intervention is absolutely required. Less than 1% of cases need surgery. In this paper, we present a schizophrenia patient who swallowed multiple lighters. Case. A 21-year-old male schizophrenic patient who uses psychotic drugs presented to the emergency department with the complaints of abdominal pain, severe vomiting, and inability to swallow for a week. His physical examination revealed epigastric tenderness. A plain radiograph of the abdomen revealed multiple tiny metallic densities. Gastroscopy was performed. The lighters were not allowing the passage, and some of them had penetrated the gastric mucosa, and bezoars were observed. One lighter was extracted with the help of the polypectomy snare. Other lighters as a bezoar were removed by surgery. Conclusion. Excessive vomiting of swallowed foreign bodies in the etiology of psychotic patients should be kept in mind. Endoscopic therapy can be performed in the early stages in these patients, but in the late stage surgery is inevitable.Öğe Long-Term Effects of Antiviral Administration on Esophageal Varice Dimensions in Cirrhotic Cases(Wiley-Blackwell, 2013) Aladag, Murat; Harputluoglu, Murat; Aladag, Hulya; Seckin, Yuksel[Abstract Not Available]Öğe Long-term efficacy of combination therapy with PEG-IFN and entecavir on HBsAg loss and anti-HBs seroconversion in patients with chronic active hepatitis(Wiley-Blackwell, 2012) Aladag, Murat; Aladag, Hulya; Harputluoglu, Murat; Seckin, Yuksel; Bilgic, Yilmaz; Karincaoglu, Melih[Abstract Not Available]Öğe Long-Term Tenofovir Therapy Reduces the Need for Liver Transplantation in Patients with Cirrhosis(Wiley-Blackwell, 2013) Aladag, Murat; Aladag, Hulya; Harputluoglu, Murat[Abstract Not Available]Öğe Outcomes following deceased and live donor liver transplantation for the indication of acute liver failure: a multicenter experience(Elsevier, 2020) Turan, Ilker; Aladag, Murat; Harputluoglu, Murat; Yilmaz, Sezai; Gencdal, Genco; Polat, Kamil Yalcin; Ozcay, Figen[Abstract Not Available]Öğe A rare malignancy in a patient with neurofibromatosis: gastric adenocarcinoma(Kare Publ, 2015) Barut, Bora; Ince, Volkan; Ozdemir, Fatih; Harputluoglu, Murat; Isik, BurakNeurofibromatosis is an autosomal dominant disease that is characterized by cutaneous hyperpigmentation and multiple neurofibromas and often accompanied by localized peripheral and central neural tumors. Gastrointestinal involvement is seen in 25% of the cases. Gastrointestinal stromal tumors, pancreatic and duodenal neuroendocrine tumors are the most common tumors in patients with neurofibromatosis. Neurofibromatosis and gastric adenocarcinoma constitute an extremely rare combination. In this case report we aim to present a patient with neurofibromatosis operated due to gastric adenocarcinoma.Öğe Real life efficacy and tolerability of Tenofovir alafenamde fumarate in liver transplant recipients: a multicenter study(Elsevier, 2022) Gokcan, Hale; Yapali, Suna; Harputluoglu, Murat; Ellik, Zeynep Melekog. Lu; Gokcen, Pinar; Adanir, Haydar; Cosar, Arif Mansur[Abstract Not Available]Öğe REAL LIFE EFFICACY AND TOLERABILITY OF TENOFOVIR ALAFENAMIDE FUMARATE IN PATIENTS WITH HEPATITIS B VIRUS-RELATED CIRRHOSIS AND LIVER TRANSPLANT RECIPIENTS. A-PRELIMINARY RESULT(Wiley, 2021) Yapali, Suna; Gokcan, Hale; Harputluoglu, Murat; Ellik, Zeynep Melekoglu; Akarsu, Mesut; Durak, Serdar; Gokcen, Pinar[Abstract Not Available]Öğe A STUDY OF ACUTE LIVER INJURY ASSOCIATED WITH ORNIDAZOLE: ANALYSIS OF 82 CASES IN TURKIYE(Lippincott Williams & Wilkins, 2023) Turan, Ilker; Durmazer, Esra Nur Nur; Vatansever, Sezgin; Caliskan, Ali Riza; Harputluoglu, Murat; Efe, Cumali; Idilman, Ramazan[Abstract Not Available]
