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    The Effect of Personality Disorders on Asthma Severity and Quality of Life
    (Tehran Univ Medical Sciences, 2014) Yilmaz, Ayse; Cumurcu, Birgul E.; Etikan, Ilker; Hasbek, Ekrem; Doruk, Sibel
    Assesment of health related quality of life (HRQL) is increasingly recognized as an important part of the patient care in asthma. We aimed to evaluate the effect of personality disorders (PDs) on HRQL and the severity of disease in asthmatic patients. Ninety seven consecutive patients with asthma and ninety healthy controls were included. All patients completed a Short Form-36 health survey (SF-36) and Structured Clinical Interview Form for DSM-III-R Axis-II Disorders (SCID-II). All SF-36 questionnaire scores of asthmatic patients were significantly lower than the controls. There were statistical differences between the asthma severity and the mean scores of vitality and emotional role difficulties of HRQL's subdomains (p=0.03, p=0.014, respectively). There was a weak but statistically significant correlation between the scores of pain and emotional role difficulties, and forced expiratory volume in 1 second (FEVI) (r=0.27, p=0.007; r=0.24, p=0.01, respectively). When compared to healthy controls, patients with asthma had higher prevalence of PDs (p=0.0001). The most common PDs found in asthmatic patients were obsessive-compulsive and avoidant PDs. HRQL values of asthma patients with PDs were significantly lower than patients without PDs except for the physical functioning subscores on HRQL. We conclude that patients with asthma have higher prevalence of PDs, which is associated with their poor quality of life. A psychiatric evaluation may be beneficial in patients with asthma if a concomitant PD is suspected.
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    Influence of ABCB1 polymorphisms and serum concentrations on venlafaxine response in patients with major depressive disorder
    (Taylor & Francis Ltd, 2017) Ozbey, Gul; Celikel, Feryal Cam; Cumurcu, Birgul Elbozan; Kan, Derya; Yucel, Berna; Hasbek, Ekrem; Percin, Ferda
    Background: The pharmacokinetics and the pharmacodynamics of antidepressants show large inter-individual variations which result in unpredictable clinical responses.Aim: The aim of the study was to examine the effect of ABCB1 polymorphisms and the serum concentrations on the efficacy and tolerability of venlafaxine in patients with major depressive disorder (MDD).Methods: Fifty-two outpatients who met the Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM-IV) criteria for MDD were recruited for the study. The severity of depression was assessed using the 17-item Hamilton Rating Scale for Depression scale (HDRS17) and tolerability was assessed based on a query regarding side-effects for 6 weeks. The ABCB1 C3435T/A and G2677T/A polymorphisms were genotyped by PCR/RFLP and steady-state serum venlafaxine concentrations were measured by high-performance liquid chromatography.Results: Patients with the TT genotype for the C3435T and the TT/TA genotype for the G2677T/A polymorphism showed significantly higher frequencies in venlafaxine-induced akathisia. This relationship was not observed for efficacy. As regards serum venlafaxine concentrations, patient groups showed no significant differences in efficacy and tolerability.Conclusion: The results suggest that individuals with the TT-TT/TA genotypes for the C3435T-G2677T/A polymorphisms of ABCB1 may be pre-disposed to a risk of akathisia.
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    Tongue edema and tongue paresthesia during immediate-release venlafaxine treatment
    (Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2009) Cumurcu, Birguel Elbozan; Ozbey, Guel; Celikel, Feryal Cam; Celikel, Serhat; Hasbek, Ekrem; Sezer, Engin
    The patient was a 34-year-old woman who was diagnosed with major depressive disorder and was stalled on venlafaxine 37.5 mg/day (immediate-release tablet formula). On the third day of venlafaxine treatment, she has developed tongue edema and paresthesia and difficulty in swallowing 10-15 minutes after ingestion of the pill. The symptoms resolved throughout the day. On the 4th day of the treatment, the same symptoms appeared once again. The case was diagnosed as hypersensitivity reaction. To our knowledge, this is the first case report presented with angioedema induced by venlataxine, which is in line with the World Health Organization's 'unexpected adverse drug reactions' definition; we reported these adverse events to Turkey Farmacovigilance Center (TUFAM) by means of the 'adverse effects reporting form'. Spontaneous reporting of the unexpected adverse events to TUFAM are necessary for the safe use of the prescribed drugs. (Anatolian Journal of Psychiatry 2009; 10:246-248)