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    An evaluation of the neutrophil-to-lymphocyte ratio as a prognostic and predictive marker in thromboangiitis obliterans
    (2018) Hemşinli, Doğuş; Altun, Gökalp
    Abstract:Aim: The aim of this study was to investigate whether the neutrophil/lymphocyte ratio is an independent predictor of poor prognosis, mortality, co-morbidities, critical limb ischmemia, amputation, or a potential prognostic biomarker predicting pathological and survival outcomes in thromboangiitis obliterans. We also investigated whether there was any relation between an increased neutrophil/lymphocyte ratio in patients with Buerger’s disease and amputation, the ultimate outcome of poor prognosis. Material and Methods: The hospital records of patients treated, followed-up and diagnosed with thromboangiitis obliterans were analyzed retrospectively. Surgical procedures performed and medical treatments applied were recorded from patients’ clinical data. Extremities exposed to the disease during its course were identified. Amputations were recorded as minor and major. Neutrophil and lymphocyte values were recorded from peripheral blood samples at time of first presentation to hospital, with the neutrophil/ lymphocyte ratio being calculated from these. One hundred ten subjects were finally enrolled as the patient group (TAO; n=110). A control group (n=49) was established consisting of smoker volunteers with no health problems. Statistical changes in neutrophil/ lymphocyte ratio values between the groups were investigated. Results: No statistically significant difference was observed between the two groups’ basic characteristics. In terms of neutrophil/ lymphocyte ratio values, a statistically significant increase was observed in the patient group compared to the control group. We observed no statistical correlation between amputations and neutrophil/lymphocyte ratio values. Conclusions: We think that the neutrophil / lymphocyte ratio, obtained easily and cheaply from routine peripheral blood samples, may be of clinical benefit in thromboangiitis obliterans.
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    The role of vascular elastography and carotid artery intima media thickness methods in the determination of non-syndromic ascending thoracic aortic aneurysm
    (2018) Turkmen, Inan Utku; Kul, Selim; Kaplan, Safiye Tuba; Vuralkan, Erkan; Baki, Gaye; Korkmaz, Ata; Ayca, Hatice; Hemşinli, Doğuş
    Abstract:Aim: The role of atherosclerosis in the pathogenesis of ascending thoracic aortic aneurysms is still uncertain. Ultrasonic elastography is a new diagnostic method, the use of which has diversified considerably in recent years. An increase in intima media thickness in the carotid arteries is an early finding of atherosclerosis. Our purpose was to investigate the effect of atherosclerosis in the development of ascending thoracic aortic aneurysms and to be able to recommend a non-invasive and inexpensive scanning method aiming at early diagnosis. Material and Methods: Thirty-three patients with ascending thoracic aortic aneurysms (aTAA group) and 40 patients with normal measurement (control group) values were included in the study. The carotid artery intima media thicknessof carotid arteries were measured using B mode ultrasonography. Elastographic examination of the intima-media was then performed. Results: Body mass index, past smoking status, hypertension, presence of coronary artery disease and hyperlipidemia were higher in the aTAA group than in the control group (p<0.05). No significant difference was determined between these two groups’ ultrasonic elastography or intima media thickness in the carotid arteries values (p<0.05). Conclusions: Our findings suggest that the effect of atherosclerosis in the pathogenesis of ascending thoracic aortic aneurysms is limited. Vascular ultrasonic elastography and intima media thickness determination in the carotid arteries appear not to be effective in the evaluation of ascending thoracic aortic aneurysms.