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    Atypical leiomyoma of the falciforme ligament of the liver
    (2018) Iflazoglu, Nidal; Tuzcu, Goksel; Baz, Vahide
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    Diagnostic Benefits and Surgical Implications of Methods for Tumor Localization in Sigmoid and Rectum Tumors
    (Mdpi, 2024) Gul, Mehmet Onur; Akcicek, Mehmet; Iflazoglu, Nidal; Corbaci, Kadir; Emir, Cuma Ali; Guzel, Mehmet; Parsak, Cem Kaan
    (1) Background: In our study, we aimed to determine the accuracy rates of imaging methods for sigmoid, rectosigmoid colon, and rectum cancer. (2) Methods: Patients with tumors located in the rectosigmoid colon, sigmoid colon, and rectum who were operated on were included. Upon admission, we examined the patients' first diagnostic colonoscopies and their preoperative repeat control colonoscopies and computed tomography (CT) report. (3) Results: In this study, 23 patients (57.5%) were male. The overall accuracy rates were 80.0% (32/40) in colonoscopy, 65.0% (26/40) in preoperative CT, and 87.5% (35/40) in retro CT, and the differences among the examination methods were statistically significant (p = 0.049). The sensitivity levels decreased to 50.0% for colonoscopy and preoperative CT and 75.0% for retro CT in rectosigmoid colon tumors. In rectal tumors, the sensitivity levels were 75.0% in colonoscopy, 60.0% in preoperative CT, and 80.0% in retro CT. In two patients, the tumor location was given incorrectly, and postoperative pathological evaluations indicated T3N0 tumors; the initially planned treatment was thus changed to include radiotherapy in addition to chemotherapy in the postoperative period because the tumor was located in the middle rectum. (4) Conclusions: Accuracy in tumor localization in sigmoid, rectosigmoid, and rectum tumors still needs to be improved, which could be accomplished with prospective studies. CT evaluations for cancer localization in this patient group should be re-evaluated by a radiologist.
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    The effect of trimethazidine on mortality in an experimental acute pancreatitis model
    (Aves, 2020) Ergucuk, Hakan; Isik, Sevil; Iflazoglu, Nidal; Kayaalp, Cuneyt; Sarac, Mehmet; Gursul, Serdar
    Background/Aims: Acute pancreatitis has a high morbidty and mortality. Its physiopathogenesis has not been enlightened up to the present. This study aims to investigate trimethazidine (antiischemic, antioxidant and cardioprotective agent) 's effects on the acute pancreatitis. Materials-Methods: In this study, four aqual groups are formed with 43 female Spraque-dawley type rats weighed between 230-300 gr (mean 265 gr). 0.9% NaCl is injected intraperitoneally after laparotomy to the Group 1 (n=6). Group 2 (n=6) is control group that without any intervention. Acute pancreatitis is formed in Group 3 (n=16) via injection of Na-taurocholate in the common bile duct. Group 4 (n=15) is being formed pancreatitis and treated with Trimetazidine. In group 4 Trimetazidine 10 mg/kg/day drugs were given, 30 minutes, 24 and 72 hours after formation of acute pancreatitis, in three equal doses by orogastric way. In all groups, the rats have been laparatomised 72 hours later under general anesthesia and pancreas tissues has been extracted and studied histopathologically. Amylase, lipase, lactate dehydrogenase, aspartate transaminase, alanine tranaminase levels in the rats serum and superoxide dismutase, catalase, glutathione, malondialdehyde, nitricoxide, protein carbonyl, glutathione peroxidase levels in the rats tissue also have been looked up. Results: Serum and tissue findings and histopathologically examination of the pancreas tissues show significant decrease in the treatment group compare to study group. Conclusion: Trimethazidine protects pancreas tissue and decreases the mortality by significantly lowering the biochemical and histopathological changes in the early stages of acute pancreatitis.
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    Parameters associated with survival in patients undergoing surgical treatment due to rectal cancer
    (2019) Gursul, Serdar; Iflazoglu, Nidal; Karabulut, Koray; Sarac, Mehmet
    Aim: Colorectal cancer is the third most common type of cancer.Approximately 1/3 of colorectal cancers are rectum cancers. The percentage of local disease stage is 39%, and the 10-year survival rate in such patients is approximately 90%. The aim of our study was to evaluate the relationship between the clinicopathological characteristics and survival of patients with rectal cancer. Material and Methods: Patients who had undergone surgical treatment for rectal cancer in our clinic between January 2008 and December 2013 were evaluated retrospectively. The effects of clinicopathological parameters of these patients on survival were investigated. The preoperative and postoperative variables were evaluated together with survival data. Results: Of the 70 patients, 30 (43%) were females and 40 (57%) were males. The median age was 61 years (min-max = 29-87 years). Eight of the patients (6%) were operated under emergency conditions due to acute abdomen or ileus. 13 (19%) of the patients had undergone laparoscopic surgery and 57 (81%) had undergone open surgical resection. 15 patients (21%) had undergone anterior resection (AR), 51 (73%) had lower anterior resection (LAR) and 4 (6%) had abdomino-perineal resection (APR). According to pTNM staging, 6 patients (8%) were at stage-0, 7 (10%) were at stage-I, 22 (32%) were at stage-II, 26 (37%) were at stage-III, and 9 (13%) were at stage IV. Conclusion: We found that the ASA (American society of Anesthesiologists) score height, final stage of the tumor and vascular (venous) invasion associated with overall survival
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    Sentinel lymph node dissection in colorectal cancers: A single-center, prospective study
    (2019) Iflazoglu, Nidal; Eren Erdogan, Kivilcim; Duran, Ali; Parsak, Cem Kaan; Doran, Figen
    Aim: In this study, we aimed to investigate the feasibility of ex vivosentinel lymph node (SLN) mapping and to evaluate efficacy of this technique on staging in patients with colorectal cancer.Material and Methods: : This single-center, prospective study included a total of 35 patients (25 males, 10 females; mean age: 55 years; range, 35 to 85 years) who were diagnosed with Stage 2 colorectal cancer between May 2015 and August 2017. All patients underwent curative surgery and SLN dissection.Results: Tumor was located in rectum in 17, in sigmoid colon in six, in right colon in seven, and in left colon in five patients. Total abdominal colectomy was performed in six, left hemicolectomy in three, right hemicolectomy in six, low anterior resection in 14, anterior resection in two, and abdominoperineal resection in four patients. Of 17 patients with clinical Stage 2 rectal cancer, 15 underwent neoadjuvant chemoradiotherapy (CRT). All patients were histopathologically diagnosed with an adenocarcinoma. Median total number of SLNs dissected was 13 with 16.9 per patient. In two patients receiving neoadjuvant CRT due to rectal cancer, a pathological complete response was achieved. The failure rate of SLNs detection was statistically significantly higher for rectal tumors than the other tumors (p=0.041) and in the patients in whom ≤7 lymph nodes dissected (p=0.023). Conclusion: Our study results suggest that SLN mapping is a useful technique with high success ratesas well as further immunohistochemical examination of the SLNs doesn’t cause stage migration. However, the success rate is lower in rectal tumors than the other tumors and in the patients with ≤7 lymph nodes dissected.