Yazar "Inan, Orhan Orcun" seçeneğine göre listele

Listeleniyor 1 - 5 / 5
  • Küçük Resim Yok
    Öğe
    Detection of Diazinon Organophosphates Using Magnetoelastic Sensor
    (Ieee-Inst Electrical Electronics Engineers Inc, 2022) Atalay, Selcuk; Ates, Burhan; Balcioglu, Sevgi; Inan, Orhan Orcun; Kolak, Seda; Simsek, Murat; Kolat, Veli Serkan
    In this study, 2826MB (Fe40Ni38Mo4B18) amorphous ferromagnetic ribbons were used as a magnetoelastic sensor (MES) to detect diazinon organophosphates (OP). Since enlarging the sensor surface area makes a significant contribution to the sensitivity of the sensor, nanofibers were coated on the sensor surface, and then, the nanofibers were functionalized with glutaraldehyde (GA) in order to covalently bind acetylcholinesterase (AChE) enzyme to the surface. It was found that binding of OPs to the AChE enzyme at the functional amorphous ribbon surface, a large change in the resonance frequency was observed. The results showed that functionalized MES shows a linear change according to the amount of OP detected in the range of 0-140 nL or 0-150 ppm in the solution.
  • Küçük Resim Yok
    Öğe
    Diagnosis, Bacterial Density, Food, and Agricultural Applications of Magnetoelastic Biosensors: Theory, Instrumentation, and Progress
    (Springer, 2024) Balcioglu, Sevgi; Inan, Orhan Orcun; Kolak, Seda; Ates, Burhan; Atalay, Selcuk
    Magnetoelastic biosensors have emerged as a promising technology for the sensitive and label-free detection of a wide range of biological analytes. These biosensors use the magnetoelastic effect, which describes how the mechanical properties of magnetostrictive materials change in response to a magnetic field. This effect is utilized to detect biological analytes by immobilizing specific recognition elements, such as antibodies or nucleic acids, on the magnetoelastic material's surface. The binding of target analytes to the recognition elements induces a mass change, leading to a shift in the resonance frequency of the magnetoelastic material. Magnetoelastic biosensors find applications across various fields, including medical diagnostics, environmental monitoring, and food safety. In medical diagnostics, they offer rapid and sensitive capabilities for detecting pathogens, biomarkers, and toxins. For environmental monitoring, they demonstrate the ability to detect pollutants and heavy metals. Furthermore, in ensuring food safety and quality, magnetoelastic biosensors detect allergens, pathogens, and contaminants effectively. Ongoing research and technological advancements suggest that these biosensors hold great potential for revolutionizing various fields, including healthcare, environmental monitoring, and food safety, contributing to improved disease diagnosis, environmental protection, and public health. This review article provides an overview of the principles, fabrication methods, diagnosis, bacterial density, food, and agricultural applications of magnetoelastic biosensors.
  • Küçük Resim Yok
    Öğe
    Magnetoelastic Humidity Sensors with TiO2 Nanotube Sensing Layers
    (Mdpi, 2020) Atalay, Selcuk; Izgi, Tekin; Kolat, Veli Serkan; Erdemoglu, Sema; Inan, Orhan Orcun
    In this study, TiO2 nanotubes (TiO2-NTs) are coated with a drop-casting method on Fe40Ni38Mo4B18 amorphous ferromagnetic ribbons and the humidity response of the prepared magnetoelastic sensors (MES) is investigated. The synthesis of TiO2-NTs is performed using a hydrothermal process. Sample characterization is carried out using X-ray diffraction and scanning electron microscopy. The results show that the sensors can measure moisture values in the range of 5% to 95% with very high precision and very low hysteresis. The humidity variation between 5% and 95% shows a change in the sensor resonance frequency of 3180 Hz, which is a significant change compared to many magnetoelastic humidity sensors developed so far.
  • Küçük Resim Yok
    Öğe
    A Positive Effect of Magnetic Field on the Catalytic Activity of Immobilized L-Asparaginase: Evaluation of its Feasibility
    (Springer, 2023) Dik, Gamze; Ulu, Ahmet; Inan, Orhan Orcun; Atalay, Selcuk; Ates, Burhan
    Enzyme immobilization is an attractive strategy to improve enzyme stability, however, the activity significantly reduces after immobilization. To solve this issue, we designed a novel magnetic carrier that both enhanced enzyme activity and improved its stability. For this purpose, the magnetic nanoparticles were synthesized and L-asparaginase was immobilized physically. All materials were structurally and morphologically characterized. Besides, the biochemical properties of the immobilized enzyme were investigated and compared with the free one. Moreover, the activity of the immobilized enzyme was investigated under a weak magnetic field. The optimum pH and optimum temperature of the free and immobilized enzyme were found to be 8.5 and 45 degrees C, 7.5 and 40 degrees C, respectively. Moreover, even after 10 cycles of use, the immobilized enzyme retained 54% of its initial activity. K-m for free and the immobilized enzyme was found to be 10.37 +/- 0.5, and 7.06 +/- 2.99 mM, respectively, and V-max was found to be 138.88 +/- 2.64, and 121.95 +/- 1.07 molimin, respectively. Most importantly, the activity increased approximately 3.2-fold and 4.3-fold at 10 Hz and 20 mT, respectively. Overall, the results suggested that, if the activity of the immobilized enzyme is very low, applying a weak magnetic field may be necessary to enhance the enzyme reaction. [GRAPHICS] .
  • Küçük Resim Yok
    Öğe
    Resonance Frequency Shift of Vibrating Amorphous Ribbon via Surface Adsorption of Magnetic Fe3O4 Nanoparticles
    (Springer, 2023) Atalay, Selcuk; Inan, Orhan Orcun; Kolat, Veli Serkan; Kaya, Ali Onur
    In this study, Fe40Ni38Mo4B18 amorphous ferromagnetic ribbon was used as a vibrating reed sensor to detect Fe3O4 magnetic nanoparticles. The sensor surface was not subjected to any treatment: the amorphous ribbon was used directly as a sensor. Nanoparticles with a diameter of 25 nm in ddH(2)O were dripped on the sensor surface at different rates. Different amounts of magnetic nanoparticles ranging from 1 to 12 mu g were dripped, and it was observed that the sensor resonance frequency decreased linearly with the mass of magnetic nanoparticles dripped. It was shown that 1 mu g MNP could be easily detected by the vibrating reed method.