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Öğe Determination of reference values for urinary neutrophil gelatinase-associated lipocalin in premature infants(Informa Healthcare, 2014) Elmas, Ahmet Taner; Tabel, Yilmaz; Ipek, SevcanBackground: The aim of this study is to determine the reference values of urinary neutrophil gelatinase-associated lipocalin (uNGAL) in healthy very preterm infants. Method: The study was performed on 30 preterm infants whose gestational ages (GA) were between 28 and 34 weeks. They were divided into three groups according to the GA as group 1: GA 28-29 weeks, group 2: 30-32 weeks and group 3: 33-34 weeks. Blood and urine samples were obtained on postnatal (PN) days 1 and 7. uNGAL was measured by ELISA. Results: There were 10 preterm infants for each group. The median values of uNGAL on PN Days 1 were 19.80 (8.6-25.7) ng/ml, 9.25 (1.42-30.3) ng/ml, and 7.95 (1.60-27.8) ng/ml in group 1, group 2 and group 3, respectively. Multivariate linear regression analysis showed that uNGAL values are not associated with GA, birth weight, and gender in preterm infants on PN Days 1 and 7. Conclusion: Our study indicated that normal values of uNGAL concentrations in healthy very preterm infants, and older children or adults are similar preterm infants.Öğe The evaluation of mean platelet volume in infants with atopic dermatitis(2019) Sanli Gunes, Hatice; Ozkars, Mehmet Yasar; Ipek, SevcanAim: Atopic dermatitis (AD) is a chronic, inflammatory skin disorder that commonly seen in the infancy period. Platelets are involved in the inflammation process. Mean platelet volume (MPV) is one of the inflammatory indicators that have been used in recent years. The aim of this study is to evaluate the relationship between the MPV and AD in infants. Material and Methods: Sixty-four infants with AD aged between 2-12 months and, 50 healthy infants as control with same age and sex were included to study. MPV values of the subjects were compared between the groups. The AD group was also divided into 3 subgroups according to the Severity Scoring of Atopic Dermatitis (SCORAD) index. Correlation analyses of MPV were performed to each group. Results: MPV levels were significantly lower in infants with AD when compared to healthy control (9.64±0.65 and 10.20±0.91, respectively, p<0.00). Both platelet and monocyte levels were significantly low in AD infants (p=0.037 and p=0.00, respectively). We also found that there was a positive correlation between platelet counts and the SCORAD index (r=0.259, p=0.039) Conclusion: A decline in MPV and platelets may be considered as an indicator of inflammation in infants with AD.Öğe Urinary Neutrophil Gelatinase-Associated Lipocalin as an Early Biomarker for Prediction of Acute Kidney Injury in Preterm Infants(Thieme Medical Publ Inc, 2014) Tabel, Yilmaz; Elmas, Ahmet; Ipek, Sevcan; Karadag, Ahmet; Elmas, Ozlem; Ozyalin, FatmaBackgroundOur aims are to determine whether the urinary neutrophil gelatinase-associated lipocalin (uNGAL) can predict acute kidney injury (AKI) development in nonseptic and nonasphyxiated but critically ill preterm infants. MethodsFifty preterm infants, gestational age (GA) between 28 and 34 weeks, were included in this case control study. Blood and urine samples were taken for blood urea nitrogen, serum creatinine, and uNGAL on postnatal (PN) days 1 and 7. uNGAL levels were measured by enzyme-linked immunoassay. Clinical and laboratory characteristics of the AKI group were compared with the non-AKI group. ResultsAKI was diagnosed in six infants during the first week. The median uNGAL levels were significantly higher in the preterm infants with AKI than those of the controls on PN days 1 and 7 (p=0.006 and p=0.023, respectively). Backward stepwise logistic regression analysis identified that 5-minute Apgar score and uNGAL levels were significantly associated with the development of AKI, even after controlling for GA, birth weight, gender, and 1-minute Apgar score in nonseptic and nonasphyxiated but critically ill preterm infants. ConclusionsuNGAL can be useful as a predictive marker of AKI in nonseptic and nonasphyxiated but critically ill preterm infants.Öğe URINARY NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN AS AN EARLY BIOMARKER FOR PREDICTION OF ACUTE KIDNEY INJURY IN PRETERM NEONATES(Oxford Univ Press, 2013) Elmas, Ahmet Taner; Tabel, Yilmaz; Ipek, Sevcan; Karadag, Ahmet; Elmas, Ozlem; Ozyalin, Fatma[Abstract Not Available]
