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    Comparison of the effects of first and second generation silicone hydrogel contact lens wear on tear film osmolarity
    (Ijo Press, 2013) Iskeleli, Guzin; Karakoc, Yunus; Ozkok, Ahmet; Arici, Ceyhun; Ozcan, Omer; Ipcioglu, Osman
    AIM: To compare the effects of first and second generation silicone hydrogel (SiH) contact lens wear on tear film osmolarity. METHODS: The healthy subjects who have never used contact lenses before were enrolled in the study. Tear film osmolarity values of 16 eyes (group 1) who wore first generation SiH contact lenses were compared with those of 18 eyes (group 2) who wore second generation SiH contact lenses after three months follow-up. RESULTS: Before contact lens wear, tear film osmolarity of groups 1 and 2 were 305.02 +/- 49.08 milliosmole (mOsm) and 284.66 +/- 30.18mOsm, respectively. After three months of contact lens wear, osmolarity values were found 317.74 +/- 60.23mOsm in group 1 and 298.40 +/- 37.77mOsm in group 2. Although osmolarity values for both groups of SiH contact lens wear after three months periods were slightly higher than before the contact lens wear, the difference was not statistically significant. CONCLUSION: Contact lens wear may cause evaporation from the tear film and can increase tear film osmolarity leading to symptoms of dry eye disease. In the current study, there is a tendency to increase tear film osmolarity for both groups of SiH contact lens wear, but the difference is not statistically significant.
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    Tear film osmolarity in patients with thyroid ophthalmopathy
    (Springer Tokyo, 2008) Iskeleli, Guzin; Karakoc, Yunus; Abdula, Arzu
    Purpose: To compare tear film osmolarity between patients with thyroid ophthalmopathy and normal healthy subjects. Methods: The tear film osmolarity in 15 normal subjects (15 eyes) (control group) and 21 patients (21 eyes) with thyroid ophthalmopathy was evaluated. Tear film osmolarity in milliosmole (mOsm) was determined by using an auto-osmometer. The palpebral fissure width, degree of proptosis, and tear break-up time (BUT) were also determined. The results for the two groups were compared statistically. Results: The mean palpebral fissure width was 9.13 +/- 0.74 mm in the healthy subjects and 13.33 +/- 1.55 mm in the thyroid ophthalmopathy patients. This difference was statistically significant (P = 0.0001). The mean proptosis was 15.33 +/- 1.39 Hertel units in the healthy subjects and 20.71 +/- 0.95 Hertel units in the patients. This difference was also statistically significant (P = 0.0001). The mean tear BUT was 6.35 +/- 1.56 s in the patients and 18.27 +/- 1.53 s in the healthy subjects, and this difference was also statistically significant (P = 0.0005). The mean tear film osmolarity was 290.80 +/- 13.58 mOsm in the healthy subjects and 340.38 +/- 18.74 mOsm in the patients. There was a statistically significant difference between the groups (P = 0.0001). Conclusions: The significantly higher tear film osmolarity in patients with thyroid ophthalmopathy was most likely due to the increased proptosis and lid fissure width. These conditions may lead to injury of the ocular surface.