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    Does the preference of peripheral versus central venous access in peripheral blood stem cell collection/yield change stem cell kinetics in autologous stem cell transplantation?
    (Pergamon-Elsevier Science Ltd, 2016) Dogu, Mehmet Hilmi; Kaya, Ali Hakan; Berber, Ilhami; Sari, Ismail; Tekgunduz, Emre; Erkurt, Mehmet Ali; Iskender, Dicle
    Central venous access is often used during apheresis procedure in stem cell collection. The aim of the present study was to evaluate whether central or peripheral venous access has an effect on stem cell yield and the kinetics of the procedure and the product in patients undergoing ASCT after high dose therapy. A total of 327 patients were retrospectively reviewed. The use of peripheral venous access for stem cell yield was significantly more frequent in males compared to females (p = 0.005). Total volume of the product was significantly lower in central venous access group (p = 0.046). As being a less invasive procedure, peripheral venous access can be used for stem cell yield in eligible selected patients. (c) 2016 Elsevier Ltd. All rights reserved.
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    Stem cell mobilization kinetics in elderly patients with multiple myeloma
    (Pergamon-Elsevier Science Ltd, 2018) Dogu, Mehmet Hilmi; Batgi, Hikmetullah; Erkurt, Mehmet Ali; Hacioglu, Sibel; Tekgunduz, Emre; Kaya, Emin; Iskender, Dicle
    In this study, we aimed to investigate whether the procedure and product kinetics differ according to age groups in advanced-age MM patients who underwent autologous HSCT. 59 patients who underwent autologous HSCT were retrospectively analyzed. Then, the patients were divided into two groups as 60-65 years and >= 65 years. It was significantly lower in >= 65 years group (p=0.008) and proportionally, the procedure duration was also significantly shortened in this group (p=0.013). Total number of collected CD34 positive stem cells was 6.20 x 106 (+/- 3.83) in 60-65 years group while it was 5.51 x 106 (+/- 2.48) in >= 65 years group with no statistically significant difference. (p=0.825). In conclusion, there was no significant difference in terms of the number of collected CD34-positive stem cells in this study that investigates the mobilization data, procedure and product kinetics, we think that successful stem cell mobilization can be performed in appropriately selected patients regardless of age. (C) 2018 Elsevier Ltd. All rights reserved.