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  • Küçük Resim
    Öğe
    Clinical efficacy and acceptability of 0.25% flurbiprofen mouthwash after periodontal flap surgery: A double-blinded, parallel-group, placebo-controlled, randomized clinical trial
    (2019) Isler, Sila Cagri; Nazim, Cise; Aydogan, Muge; Dinc, Memnune; Bakhishov, Hikmat; Ozdemir, Burcu
    Aim: The aim of the present study was to investigate the analgesic and anti-inflammatory efficacy of 0.25% flurbiprofen mouthwash, and to evaluate its effect on the parameters related to patient morbidity and early wound healing after periodontal flap surgery.Material and methods: Thirty-two patients (19 females and 13 males), diagnosed with moderate periodontitis and presenting at least one quadrant scheduled for periodontal flap surgery, were randomly allocated to either the flurbiprofen group or the placebo group. The plaque index (PI), gingival index (GI), probing pocket depth (PPD), bleeding on probing (BOP) and clinical attachment level (CAL) were evaluated at baseline and PI and GI were re-evaluated at 30-day follow-up. On postoperative 1, 3, 7, 14 and 30 days, postoperative pain, discomfort, changes in patients’ dietary habits, burning sensation and postoperative swelling were analyzed by using a visual analog scale (VAS). At postoperative 7 days, the early wound healing index was assessed clinically.Results: The mean VAS scores exhibiting postoperative pain were significantly lower in flurbiprofen group compared to placebo group at days 1, 7 and 30 (p0.05). Flurbiprofen group had significantly lower scores compared to the placebo group at 14-day follow-up in terms of changes in patients’ dietary habits (p0.05), as well as burning sensation at the first postsurgical day (p0.05). At 30-day follow-up examination, the mean GI values were significantly higher for the placebo group (p0.05).Conclusion: A postsurgical protocol including rinsing with a 25% flurbiprofen mouthwash revealed better analgesic and anti-inflammatory effect and moreover, had a beneficial impact in terms of patient morbidity after periodontal flap surgery.Keywords: Flurbiprofen; Inflammation; Postoperative Pain; Periodontal Flap Surgery.
  • Küçük Resim
    Öğe
    The efficacy of ozone therapy on free gingival graft augmentation around dental implants
    (2018) Isler, Sila Cagri; Uraz, Ahu; Soysal, Fatma; Unsal, Fatma Berrin; Cetiner, Deniz
    Aim: The implants exhibiting lack of keratinized mucosa (KM) may be more prone to the early stage of peri-implant infection. The aim of the present study was to evaluate topical ozone therapy on free gingival graft (FGG) healing in terms of augmenting KM around the implants during 6-month follow-up. Material and methods: Thirty patients (16 women and 14 men) with inadequate KM around their implants were randomly allocated to either the ozone group (FGG + Ozone therapy) or the control group (FGG alone). The width and thickness of KM, plaque index (PI), gingival index (GI), probing depth (PD), mucosal recession (MR) and clinical attachment level (CAL) were evaluated at baseline, 1, 3 and 6 months. During 14 days postoperatively, patient’s pain perception was analyzed by using a visual analog scale analog scale (VAS). At 14 days, quality of life was also assessed via the Oral Health Impact Profile-14 (OHIP-14). Results: No significant differences were found between ozone and control groups with respect to KM dimensions at any study follow-up periods (p>0.05). Ozone group provided significantly higher CAL and MR values at 6 months compared to baseline values. Moreover, ozone group exhibited significantly lower GI values compared to the control group at 6 months (p<0.05). No significant difference was observed between the groups for postoperative VAS values and total OHIP-14 scores (p>0.05). Conclusion: Adjunctive ozone therapy did not provide any beneficial impact on the dimension of obtained KM around the implants at 6 months. However, ozone therapy may give rise to less mucosal inflammation around the implants compared to spontaneous healing