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Öğe Analysis of the association between hand preference incidence in young healthy individuals and gender dominant eye 2D 4D ratio and hand grip strength(Azerbaijan Medical Association Journal, 2016) Çay, Mahmut; Şenol, Deniz; Çuğlan, Songül; Köse, Evren; Özbağ, DavutObjective: The purpose of this study is to examine the association between hand preference in young healthy individuals and handgrip strength (HGS), (which is accepted to be an objective measurement in the assessment of gender), 2D:4D ratio (ratio of the length of index finger to that of ring finger), eye dominance and upper limb performance. Methods: A total of 198 individuals, 111 males and 87 females, participated in our study. Oldfield Inventory was used to find out hand preference. Baseline hand dynamometer was used to find out HGS. The test developed by Rosenbach was used for determination of the dominant eye. For assessment of 2D:4D ratio, measurement was made starting from the basal fold of the finger to the fingertip. Results: According to the results of the statistical analysis, no significant difference was found between hand preference and 2D:4D (p>0.05). Statistically significant difference was found between eye dominance and hand preference (p<0.05). Statistically significant difference was found between right and left hand preference and right and left HGS of males (p<0.05). Statistically significant difference was found between right hand preference and right and left HGS of females (p<0.05), where significant difference was not found between left hand preference and right and left HGS of females (p>0.05). Conclusions: The association of hand preference with other parameters is important to determine cerebral lateralization. We believe that the result which shows hand preference was directly proportional to eye dominance and HGS means that these parameters can be a guide in determining the dominant hemisphere.Öğe Analysis of the dermatoglyphics of patients with obstructive sleep apnea(Medicine Science, 2019) Canbolat, Mustafa; Ermiş, Hilal; Çevirgen, Furkan; Şenol, Deniz; Karataş, Turgay; Köse, Evren; Özbağ, DavutÖz: Dermatoglyphics outside the normal distribution may be signal of hereditary anomaly in prenatal period. Obstructive sleep apnea syndrome (OSAS) is defined as the suspension of breathing for 10 seconds or more. Genetic predisposition can be suggesated in the OSAS. The aim of this study is to assess through dermatoglyphics whether genetic factors are effective in OSAS because skin glyphs and pharyngeal are originate from ectoderm. Our study was conducted with 134 volunteers, 68 (21 females, 47 males) individuals with OSAS and 66 (21 females, 48 males) healthy individuals. The photographs of the palms and fingertips of the right and left hands of the participants were taken with high definition cameras. These images were enlarged with computer and their dermatoglyphics were assessed. Fingertip loop types, total number of fingertip lines, total a-b line numbers and atd angles were assessed in healthy individuals and patients with OSAS. We found a statistically significant difference between the right and left hand atd values of healthy individuals and individuals with OSA. atd values can be used as an early indicator of OSAS.Öğe Ankilozan spondilit’li erkek hastaların omurga deformitelerinin ve günlük yaşam kalitesinin değerlendirilmesi(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2014) Canbay, Özden; Köse, Evren; Öner, Zülal; Altay, Zuhal; Ekinci, NihatAmaç: Postür, vücudun her hareketinde eklemlerin aldığı pozisyonların birleşimidir. Çalışmamızın amacı; Ankilozan Spondilit’li (AS) hastalarda postür analizine bakılarak omurga deformitelerinin belirlenmesi ve bunların AS’li hastaların günlük yaşam aktiviteleri ve kalitesi üzerine nasıl bir etkide bulunduğunun araştırılmasıdır. Gereç ve Yöntem: Çalışmaya 30 AS’li ve 30 sağlıklı birey alındı. Tüm bireylere postür analizi, SF-36 yaşam kalitesi değerlendirme anketi ve Beck Depresyon ölçeği uygulandı. Kaslarda kısalık ve kas kuvveti değerlendirildi. Bulgular: Postür analizi değerlendirmesi sonucunda hasta bireylerin torakal kifoz artışı, lumbal lordozda azalma, yuvarlak omuz, genu valgum ve pes planus deformitelerinin anlamlı oranda arttığı gözlendi. Vücut kitle indeksi ortalamaları ile postür analizi sonuçlarından servikal lordozda artış, düşük omuz ve genu varum açısından anlamlı bir fark bulunmadı. Belirli kas gruplarında ise kas kuvvetinde azalma ve kas kısalığı tespit edildi. Ankilozan spondilit’li hastalarda yaşam kalitesinin postüre bağlı olarak olumsuz etkilendiği belirlendi. Sonuç: Ankilozan spondilit’li hastalarda postürün bozulduğu, kaslardaki kısalığın hareketleri sınırlandırdığı ve buna bağlı olarak ortaya çıkan kas zayıflamasından dolayı yaşam kalitesinin düştüğü düşünülmektedir. Ayrıca eğitim seviyesi düşük olan bireylerin, hastalık hakkında yeterli bilgiye sahip olmadığı ve gereken önemi göstermedikleri görülmektedir.Öğe Böbrek alt kaliks infundibulum çapının eswl başarısına etkisi(İnönü Üniversitesi Sağlık Bilimleri Dergisi, 2013) Köse, Evren; Oğuz, Fatih; Beytur, AliBöbrek alt pol yapısından dolayı alt kaliks taşlarının tedavisi diğer kalisiel yapılara göre daha az başarılıdır. Kaliks boşluğu ile renal pelvis arasındaki anatomik bölüm olan infundibulum, kırılan taşların kaliks dışına atılmasını etkileyen faktörlerden birisidir. Böbrek taşlarının tedavisinde, vücut dışından şok dalgalarıyla taş kırma işlemi günümüzde yaygın bir şekilde kullanılmaktadır. Bu çalışmada, alt pol kaliks taşlarına şok dalga tedavisi uygulanan hastaların verileri incelenerek infundibulum çapının başarıya etkisi araştırıldı. Hastalar, infundibulum çapları 5 mm ve altı ile 5 mm üstü olmak üzere iki gruba ayrıldı. Sonuç olarak, benzer taş özelliğine sahip hastalar göz önüne alındığında, infundibulum çapı 5 milimetreden büyük olanlarda taş kırma işleminin daha başarılı olduğu görüldü.Öğe Corona mortis in vivo anatomical knowledge and the risk of injury in totally extraperitoneal inguinal hernia repair(Hernia, 2015) Ateş, Mustafa; Kınacı, Erdem; Köse, Evren; Soyer, Vural; Sarıcı, Kemal Barış; Çuğlan, Songül; Korkmaz, Mehmet Fatih; Dirican, AbuzerPurpose Corona mortis (CMOR) is the arterial and/or venous vascular communication(s) between the obturator and external iliac vessels. Totally extraperitoneal (TEP) inguinal hernioplasty can be associated with vascular complications especially during the fixation of the mesh. Theoretically, CMOR is an important nominee. But, the data in literature are insufficient about CMOR injury. Additionally, most of the studies about CMOR have been usually performed on cadavers. We aimed to reveal the preperitoneal vascular anatomy of inguinal area and provide in vivo knowledge about CMOR. The risk of arterial injury was also evaluated. Materials The data of preperitoneal vascular anatomy of 321 patients who underwent TEP procedure between January 2005 and July 2014 were retrospectively evaluated. Results Mean age was 46 ± 8.9 years, 53 females vs 268 males. 391 hemipelvises were evaluated. Two types of arterial structure were identified; (1) an aberrant obturator artery forming an anastomosis with branches of ordinary obturator artery; (2) a pubic branch of inferior epigastric artery. The incidence of arterial CMOR was 28.4 % and of any arterial structure was 45.0 %. An arterial CMOR was considered as thick (C2 mm) or thin (\2 mm). Injury of arterial CMOR during tack stapling on Cooper’s ligament was seen in six cases (1.5 %). All of them were thin (\2 mm) in structure. Venous CMOR was visible only under low pressure in work space. Conclusion During TEP hernia repair, CMOR and/or pubic branch of inferior epigastric artery can be damaged. To prevent this complication, tacks should be stapled to Cooper’s ligament close to symphysis pubis and dissection should be careful on the posterior surface of superior pubic ramus. Small caliber (\2 mm) arterial CMOR is more prone to be injured during TEP procedure. To explore venous structures properly, pressure in workspace should be kept as low as possible.Öğe THE EFFECT OF POSTURAL KINESIOTAPING IN THE TREATMENT OF THORACIC KYPHOSIS(Journal of Turkish Spinal Surgery, 2019) Çavuş, Fatih; Çetin, Aymelek; Korkmaz, Mehmet Fatih; Şenol, Deniz; Köse, Evren; Özbağ, DavutÖz: Purpose: The purpose of this study is to find out whether postural kinesio taping (KT) contributes to decreasing kyphosis angle in adolescents who have increased thoracic kyphosis. Within this context, our purpose was to contribute to treatment of thoracic kyphosis as an additional method. Material and Method: 50 adolescents between 10 and 18 years of age who referred to Orthopedics and Traumatology Polyclinic and who were diagnosed with thoracic kyphosis after required examinations participated in the study voluntarily. The patients were randomly grouped in two. One of the groups was exercise group (Ex), while the other was both exercise and taping (Ex-KT) group. At the beginning of the study, thoracic kyphosis values of all the patients in the study were measured by an orthopedist based on Cobb method. The groups consisted of 25 patients. Consent was taken from all participants with pediatric informed consent form. The same exercises were given to both groups. The patients were asked to make two types of exercises daily. The first exercise was 20 body hyperextensions in prone position. The second exercise was a rhythmic swimming movement done as if diving into the water and coming out of the water. This swimming movement would be done 5 minutes each day. The exercises were followed daily under the supervision of a physiotherapist. Only these exercises were given to Ex group. After Ex-KT group made the exercises, KT was applied on their upper backs. KT application was renewed each week. The participants were referred to the orthopedist again for measurement following a 6-week program. Final measurement results the orthopedist conducted with Cobb method were compared with the first measurement results. Results: No statistically significant difference was found between the average pre- treatment and post-treatment kyphosis degrees of males and females in the Ex group (p> 0,05). Statistically significant difference was found between the average pre-treatment and post-treatment kyphosis degrees of males and females in the Ex-KT group (p<0,05). Conclusion: In the present study, it was found that KT technique had positive results in terms of decreasing increased thoracic kyphosis. We are of the opinion that it will be useful to apply KT technique with other treatment protocols in the treatment of increased thoracic kyphosis. We believe that the results of this study will be a reference for future studies. We are of the opinion that studies with longer periods of time should be conducted to have a clear idea about the effects of KT on thoracic kyphosis.Öğe Evaluation of morphometry in extrahepatic bile ducts in preoperative and postoperative periods in diabetic and non - diabetic patients with cholelithiasis(2020) Karataş, Turgay; Özbağ, Davut; Ögetürk, Murat; Demirtaş, Gökhan; Şenol, Deniz; Çevirgen, Furkan; Canbolat, Mustafa; Köse, Evren; Dirican, Abuzer; Kanlıöz, MuratAbstract: Aim: The aim of this study was to find out and to compare the effect of cholecystectomy performed due to gallstone on the extrahepatic bile ducts morphometry in diabetic and non-diabetic patients. Material and Methods: Three groups consisting of a total of 120 individuals. Diabetic patients with cholelithiasis (DC group) consisted of 40 person, non-diabetic patients with cholelithiasis (N-DC group) consisted of 40 person and healthy group (H group) consisted of 40 person. Laparoscopic cholecystectomy was performed on individuals with cholelithiasis. DHC (ductus hepaticus communis) diameter was measured below hepatic canal bifurcation from mucosa to mucosa by ultrasonography. The measurements were conducted in preoperative period and in the third and sixth postoperative months. Results: There were no significant differences between DC and N-DC groups in terms of DHC diameters in preoperative period and postoperative third and sixth months. In both DC and N-DC groups, DHC diameters in postoperative third and sixth months were found to show a small but statistically significant increase. Conclusion: This study showed a small but statistically significant dilatation in DHC following cholecystectomy. In addition, no statistically significant difference was found between DC and N-DC groups in terms of post- cholecystectomy DHC dilatation.Öğe An Evaluation of Spinal Deformities and Quality of Life in Male Patients with Ankylosing Spondylitis(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2014) Canbay, Özden; Köse, Evren; Öner, Zülal; Altay, Zühal; Ekinci, NihatObjective: Posture is a combination of the positions which is taken by the joints in every movement of the body. The aim of this study is to determine the spine deformities by posture analysis in patients with ankylosing spondylitis, and, additionally, to evaluate the effects of these deformities on daily life activities and patients’ quality of life. Material and Methods: Thirty patients with ankylosing spondylitis and thirty healthy subjects were included in the study. Posture analysis, through SF-36, and Beck Depression Inventory were applied to all individuals. Shortening of muscles and muscle strength were evaluated. Results: An increase in thoracic kyphosis, a decrease in lumbar lordosis, deformities of round shoulder, genu valgum and pes planus were significantly prominent in the AS group compared to the healthy group. In both groups, no significant differences were found between means of their body mass index, increased cervical lordosis, low shoulder, and genu varum. There was a decrease of muscle strength and an increase of shortening of muscle in certain muscle groups. It was determined that quality of life in AS patients was negatively affected by posture. Conclusion: The physiologic and psychological status of patients with ankylosing spondylitis affects their quality of life because of the abnormal posture and weakness of the muscles resulting from the limitation of movement. The patients did not have enough information on their disorders and did not take care of the importance of the disease.Öğe First laparoscopic totally extraperitoneal repair of Laugier s hernia a case report(Hernia, 2013) Ateş, Mustafa; Dirican, Abuzer; Köse, Evren; Işık, Burak; Yılmaz, SezaiAn atypical femoral hernia developing through the lacunar ligament is called Laugier’s hernia. Preoperative diagnosis of these atypical hernias is very difficult because of their rarity and similar clinical appearance to conventional femoral hernias. A 52-year-old female presented with right groin swelling. During laparoscopic totally extraperitoneal (TEP) inguinal hernia repair, a hernia sac through an opening in the lacunar ligament was diagnosed and repaired with mesh covering the inguinal floor. The surgeon should be alert to the possibility of an atypical femoral hernia when examining patients with inguinal hernias. A laparoscopic approach should be chosen instead of a conventional approach for the treatment of femoral hernias because of its high diagnostic and therapeutic capacity for all types of femoral hernia, including Laugier’s.Öğe First laparoscopic totally extraperitoneal repair of Laugier s hernia a case report(Hernia, 2013) Ateş, Mustafa; Dirican, Abuzer; Köse, Evren; Işık, Burak; Yılmaz, Sezait An atypical femoral hernia developing through the lacunar ligament is called Laugier’s hernia. Preoperative diagnosis of these atypical hernias is very diYcult because of their rarity and similar clinical appearance to conventional femoral hernias. A 52-year-old female presented with right groin swelling. During laparoscopic totally extraperitoneal (TEP) inguinal hernia repair, a hernia sac through an opening in the lacunar ligament was diagnosed and repaired with mesh covering the inguinal Xoor. The surgeon should be alert to the possibility of an atypical femoral hernia when examining patients with inguinal hernias. A laparoscopic approach should be chosen instead of a conventional approach for the treatment of femoral hernias because of its high diagnostic and therapeutic capacity for all types of femoral hernia, including Laugier’s.Öğe Investigation of the effects of ısorhamnetin on motor function, sedation and analgesia in the diabeticrats(KARGER, ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND, 2018) Kurukafa, Diğdem; Köse, Evren; Parlakpınar, Hakan; Özhan, Onural; Yaşar, ŞeymaÖğe Kimmerle s anomaly posterior osseous bridging of atlas(Medicine Science | International Medical Journal, 2015) Şenol, Deniz; Canpolat, Mustafa; Ulutaş, Nihal Sümeyye; Çay, Mahmut; Çuğlan, Songül; Köse, Evren; Özbağ, DavutKimmerle’s anomaly is a rare and serious pathology of the 1st cervical vertebra, which may sometimes lead to hardly explicable changes in vertebrobasilar circulation. Also known as ponticulus posticus (PP), this phenomenon encircles the vertebral artery and suboccipital nerve and is associated with vertigo, vertebro-basilar insufficiency, neck pain, shoulder pain and cervicogenic headache symptoms. It can also lead to migraine as a result of its interaction with dura. As the knowledge of this variant by clinicians is important for obtaining a fast result in the treatment, it should also be taken into account in surgical approaches so as not to harm the vessels and nerves in this area.Öğe Metotreksat’ın Neden Olduğu Akut Böbrek Hasarına Karşı Montelukast’ın Etkileri(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2011) Köse, Evren; Beytur, Ali; Vardı, Nigar; Türköz, Yusuf; Ekinci, Nihat; Ekincioğlu, ZülalMetotreksat’ın neden olduğu böbrek hasarına karşı montelukast’ın etkileri araştırıldı. Gereç-Yöntem: 35 adet Wistar albino dişi sıçan 5 gruba ayrıldı: Grup I: Kontrol (K); Grup II: Montelukast (ML); Grup III: Metotreksat (Mtx); Grup IV: Önce metotreksat sonra montelukast verilen grup (Mtx+ML); Grup V: Önce montelukast sonra metotreksat uygulanan grup (ML+Mtx) olacak şekilde ayarlandı. Son uygulamalardan 24 saat sonra hayvanlar sakrifiye edilerek böbrek dokuları ve kanları alındı. Böbrek dokuları hem histolojik incelemeler hem de MDA analizi için kullanıldı. Kandan elde edilen serumlarda ise BUN ve Cr seviyeleri değerlendirildi. Bulgular: Sadece metotreksat uygulanan grupta kontrol grubuna gore MDA, BUN ve Cr seviyelerinde anlamlı bir artış tespit edildi. Bunun yanı sıra metotreksat enjeksiyonundan sonra montelukast verilen grupta bu parametreler düşmüştü. Histolojik olarak sadece metotreksat verilen grupta belirgin tübül hasarı varken montelukastın her iki uygulaması ise bu hasarları geriletmişti. Sonuç: Metotreksat’ın neden olduğu deneysel böbrek hasarında, montelukast’ın bu hasarı azalttığı ortaya kondu.Öğe Nadir görülen bir vaka: 3d-cta ile tanımlanmış truncus thyrolingualis ve arteria facialis yokluğu(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2013) Öner, Zülal; Öner, Serkan; Köse, Evren; Kamışlı, Suat; Saraç, KayaArteria carotis externa’nın (ECA) dallarından ayrılan truncus thyrolingualis’in (TLT) anatomik bir varyasyon olduğu iyi bilinmektedir. Ancak TLT nadiren de olsa arteria carotis communis’ten (CCA) köken almaktadır. Biz burada 59 yaşında tanımlanmış serebrovasküler hastalığı (SVH) olan bir erkek hastada karotis stenozunu ve intrakraniyal vasküler yapıları değerlendirmek amacıyla üç boyutlu CT anjiyografi (3D-CTA) çekilmesi sonucunda rastladığımız sol CCA’dan köken alan TLT olgusunu sunmaktayız. TLT, sol CCA’nın anterior yüzünden ayrılmaktaydı. TLT’nin CCA’dan çıkış yerinde infundibuler dilatasyon meydana gelmişti. Sağ tarafta ise süperfisyal temporal arter (STA), CCA anterior yüzünden çıkmaktaydı. Ayrıca bu vakada rastladığımız nadir görülen bir varyasyon da arteria facialis (FA) yokluğuydu. Sağ tarafta FA gözlenirken sol tarafın FA’sı gözlenmemiştir. Boyun bölgesine ait arter varyasyonlarının bilinmesi bu bölgeye ait patolojilerin tanı ve tedavisi açısından oldukça önemlidir.Öğe Nadir Görülen Bir Vaka: 3D-CTA ile Tanımlanmış Truncus Thyrolingualis ve Arteria Facialis Yokluğu(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2013) Öner, Zülal; Öner, Serkan; Köse, Evren; Kamışlı, Suat; Saraç, KayaArteria carotis externa’nın (ECA) dallarından ayrılan truncus thyrolingualis’in (TLT) anatomik bir varyasyon olduğu iyi bilinmektedir. Ancak TLT nadiren de olsa arteria carotis communis’ten (CCA) köken almaktadır. Biz burada 59 yaşında tanımlanmış serebrovasküler hastalığı (SVH) olan bir erkek hastada karotis stenozunu ve intrakraniyal vasküler yapıları değerlendirmek amacıyla üç boyutlu CT anjiyografi (3D-CTA) çekilmesi sonucunda rastladığımız sol CCA’dan köken alan TLT olgusunu sunmaktayız. TLT, sol CCA’nın anterior yüzünden ayrılmaktaydı. TLT’nin CCA’dan çıkış yerinde infundibuler dilatasyon meydana gelmişti. Sağ tarafta ise süperfisyal temporal arter (STA), CCA anterior yüzünden çıkmaktaydı. Ayrıca bu vakada rastladığımız nadir görülen bir varyasyon da arteria facialis (FA) yokluğuydu. Sağ tarafta FA gözlenirken sol tarafın FA’sı gözlenmemiştir. Boyun bölgesine ait arter varyasyonlarının bilinmesi bu bölgeye ait patolojilerin tanı ve tedavisi açısından oldukça önemlidir.Öğe A rare anatomic variation of the chorda tympani(Kulak Burun Boğaz İhtisas Dergisi, 2011) Kalcıoğlu, M. Tayyar; Köse, Evren; Bayındır, Tuba; Duman, SerdarÖz: Korda timpani, timpanik kavitenin önemli anatomik yapılarından biridir. Bazı anatomik varyasyonları olabilir. Bu anatomik varyasyonlar belirli otolojik cerrahi işlemlerde önem taşımaktadır. Literatürde korda timpaninin anatomik varyasyonlarıyla ilgili sınırlı sayıda yayın bulunmaktadır. Kırk dokuz yaşında kadın hasta sağ kulakta iletim tipi işitme kaybı ve kulak zarı perforasyonu nedeniyle kliniğimize sevk edildi. Timpanoplasti ameliyatı sırasında timpanomastoid flep eleve edildiği sırada, daha önce tanımlanmamış bir anatomik varyasyon olarak korda timpaninin flep ile kemik arasında seyrettiği görüldü. Bu yazıda korda timpaninin tanımlanmamış bir anatomik varyasyonu sunuldu. Başlık (İngilizce): Korda timpaninin nadir bir anatomik varyasyonu Öz (İngilizce): The chorda tympani is an important anatomical structure in the tympanic cavity. It may have some anatomic variations. Its anatomic variations are of interest in certain otologic surgical procedures. There are limited reports in the literature about the variations of the chorda tympani. A 49-year-old female patient was refered to our clinic because of conductive hearing loss and tympanic membran perforation in the right ear. During the tympanoplasty surgery, when the tympanomastoid flap was elevated, the chorda tympani was seen between flap and bone as a non-described anatomic variation. This article presents a non-described anatomic variation of the chorda tympani.Öğe A rare congenital vascular anomaly: A case of left-sided inferior vena cava - computed tomography findings(2012) Koç, Mustafa; Köse, Evren; Sarsılmaz, Mustafa[Abstract Not Available]Öğe The role of chrysin against harmful effects of formaldehyde exposure on the morphology of rat fetus liver and kidney development(Medicine Science | International Medical Journal, 2016) Çuğlan, Songül; Ekinci, Nihat; Yıldız, Azibe; Doğan, Zümrüt; Sapmaz, Hilal Irmak; Vardı, Nigar; Özyalın, Fatma; Bakırcı, Sinan; Çay, Mahmut; Köse, Evren; Türköz, Yusuf; Özbağ, DavutThis study was aimed to investigate possible harmful effects of formaldehyde (FA) exposure on the morphology of fetus liver and kidney development during pregnancy and also to determinate possible protective role of chrysin (CH) against these harmful effects. For this aim, after pregnancy was induced, 58 female rats were divided into 6 groups. Serum physiologic (SF) was injected to the Group I rats intraperitoneally (i.p.). 20 mg/kg CH was given to the Group II via gavage. 0.1 mg/kg FA was applied to the Group III (i.p.), 1 mg/kg FA was injected to Group IV (i.p.) 0.1 mg/kg FA was given to Group V i.p., and 20 mg/kg CH was given to the same group via gavage. 1 mg/kg FA was applied to Group VI i.p., and 20 mg/kg CH was given to the same group via gavage. Fetuses were taken from each pregnant rat with cesarean section on the 20th day of the pregnancy. The morphological analyses of the fetuses, liver and kidney; biochemical and histological analyses of the liver and kidney were performed. The fetal body, liver and kidney weight of the FA groups demonstrated a statistically significant decrease the compared to control group. Also the FA-1 group were observed histopathological changes on the fetus liver and kidneys. FA exposure causes harmful effects on fetus the liver and kidneys. CH reduces the negative effect on morphological variables statistically. Although CH is insufficient to fix the histopathological changes that occur in the liver, damaging effects that occur in the kidney decreased statistically.Öğe Solunum yoluyla formaldehit ve lavanta uygulanan sıçan teslislerinin değerlendirilmesi; bir histolojik çalışma(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2010) Köse, Evren; Sarsılmaz, Mustafa; Meydan, Sedat; Pekmez, Hıdır; Dabak, Durrin Özlem; Kavaklı, Ahmet; Ögetürk, MuratÖz: Amaç: Çalışmamızda, solunum yolu ile uygulanan formaldehit’in sıçan testislerinde yaptığı hasar histolojik olarak araştırıldı. Aynı zamanda, bu hasarlara karşı aromaterapi uygulamalarında sık kullanılan lavanta yağının muhtemel koruyucu etkileri de incelendi. Gereç-Yöntem: Bu amaçla, 21 adet Wistar-Albino cinsi erkek sıçan kullanıldı. Grup I’deki sıçanlar kontrol olarak kullanılırken, Grup II’deki sıçanlar, 35 gün boyunca solunum yoluyla formaldehit’e (10 ppm/1saat) maruz bırakıldı. Grup III’deki sıçanlara ise formaldehit uygulamasının yanı sıra saf lavanta yağı (1ml/1saat) yine solunum yoluyla verildi. Uygulama sonunda hayvanlar sakrifiye edildi ve histolojik incelemeler için testisler çıkarıldı. Çalışmada, tubuli seminiferi contorti çapları, Leydig hücre sayıları ve çekirdek hasarlı Leydig hücreleri incelendi. Bulgular: Formaldehit’e maruz kalan sıçanlar kontrol grubu ile karşılaştırıldığında, tubül çapları ve Leydig hücre sayılarında azalma, çekirdek hasarlı Leydig hücrelerinde ise artma tespit edildi. Ayrıca tubül duvarlarında atrofik değişiklikler gözlendi. Formaldehit maruziyetiyle birlikte lavanta yağı uygulanan grupta ise, formaldehit maruziyetine bağlı olarak testiste gelişen histolojik değişikliklerin düzelmiş olduğu belirlendi. Sonuç: Solunum yolu ile formaldehit maruziyetine bağlı olarak testiste önemli histolojik hasarların meydana geldiği ve bu hasarlara karşı lavanta yağının koruyucu özellik gösterdiği tespit edildi. Başlık (İngilizce): The histological evaluation of the testes of rats which applied formaldehyde and lavender oil Öz (İngilizce): Aim: In our study, harmful effects of formaldehyde (FA) inhalation on the testes were investigated histologically. In addition, the possible protective effects of lavender oil which often used in aromatherapy, were examined against these damages. Material-Methods: For this purpose, 21 albino-Wistar rats were used. The rats of group I was used as control group. The rats of group II were exposed FA (10 ppm/ 1hour) for 35 days. The rats of group III inhaleted lavender oil (1ml/1 hour) with FA. At the end of the experiment, all rats were sacrified and testes were removed for histological examination. In this examination, the diameters of seminiferous tubul, Leydig cells and Leydig cells with damaged nucleus were determined. Results: When the rats were exposed to formaldehyde compared with the control group, it was determined that the diameter of tubuls and number of Leydig cells were decreased and Leydig cells with damaged nucleus were increased. And also it was seen that there were atrophic changes in the tubuls. In the group in which the lavender oil was applied with formaldehyde exposure it was determined that the histological changes of testes occured via FA exposure were improved. Conclusion: It was shown that harmful effects of FA on testes occured via formaldehyde exposure and lavender oil have protective effects to the these damages.Öğe Solunum Yoluyla Formaldehit ve Lavanta Uygulanan Sıçan Testislerinin Değerlendirilmesi; Bir Histolojik Çalışma(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2010) Köse, Evren; Sarsılmaz, Mustafa; Meydan, Sedat; Pekmez, Hıdır; Dabak, Durrin Özlem; Kavaklı, Ahmet; Ögetürk, MuratÇalışmamızda, solunum yolu ile uygulanan formaldehit’in sıçan testislerinde yaptığı hasar histolojik olarak araştırıldı. Aynı zamanda, bu hasarlara karşı aromaterapi uygulamalarında sık kullanılan lavanta yağının muhtemel koruyucu etkileri de incelendi. Gereç-Yöntem: Bu amaçla, 21 adet Wistar-Albino cinsi erkek sıçan kullanıldı. Grup I’deki sıçanlar kontrol olarak kullanılırken, Grup II’deki sıçanlar, 35 gün boyunca solunum yoluyla formaldehit’e (10 ppm/1saat) maruz bırakıldı. Grup III’deki sıçanlara ise formaldehit uygulamasının yanı sıra saf lavanta yağı (1ml/1saat) yine solunum yoluyla verildi. Uygulama sonunda hayvanlar sakrifiye edildi ve histolojik incelemeler için testisler çıkarıldı. Çalışmada, tubuli seminiferi contorti çapları, Leydig hücre sayıları ve çekirdek hasarlı Leydig hücreleri incelendi. Bulgular: Formaldehit’e maruz kalan sıçanlar kontrol grubu ile karşılaştırıldığında, tubül çapları ve Leydig hücre sayılarında azalma, çekirdek hasarlı Leydig hücrelerinde ise artma tespit edildi. Ayrıca tubül duvarlarında atrofik değişiklikler gözlendi. Formaldehit maruziyetiyle birlikte lavanta yağı uygulanan grupta ise, formaldehit maruziyetine bağlı olarak testiste gelişen histolojik değişikliklerin düzelmiş olduğu belirlendi. Sonuç: Solunum yolu ile formaldehit maruziyetine bağlı olarak testiste önemli histolojik hasarların meydana geldiği ve bu hasarlara karşı lavanta yağının koruyucu özellik gösterdiği tespit edildi.