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    Antibacterial and Antioxidant Activity Evaluation of Bis-Substituted İsovanillin Derivatives
    (Turkish Chemical Society, 2023) Tekin Z.; Tekeli Y.; Küçükbay Z.; Lolak N.; Yapar G.; Akocak S.
    Herein, a series of twelve bis-hydrazone substituted isovanilline derivatives 3(a-l), were freshly re-synthesized by the reaction of bis-aldehydes with substituted hydrazide derivatives since these compounds previously showed potent aldose reductase inhibition properties. The obtained compounds were tested for their potential antibacterial and antioxidant activities. In the present study, four different bacterial strains were used, including Gram-positive (Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212) and Gram-negative (Pseudomonas aeruginosa ATCC 10231, Escherichia coli ATCC 25912). On the other hand, the antioxidant capacities of freshly re-synthesized bis-hydrazone substituted isovanilline derivatives were determined by using several antioxidant methods, including DPPH free radical scanvenging, TEAC cupric reducing (CUPRAC) and metal chelating activity methods. Several lead molecules were discovered as a potential bacterial inhibitors against S. aureus and E. coli bacterial strains. More specifically, compounds 3g (R=-H) and 3j (R=-4Cl) showed great inhibition properties against E. coli bacterial strains by having MIC values of 1.56 and 6.25 µg/mL, respectively. Moreover, none of the compounds showed potent antioxidant activity against tested methods with respect to compared standards. © 2023, Turkish Chemical Society. All rights reserved.
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    Trace element status (Se, Zn, Cu) in heart failure
    (2006) Koşar F.; Şahin I.; Taşkapan Ç.; Küçükbay Z.; Güllü H.; Taşkapan H.; Çehreli Ş.
    Objective: It has been speculated that trace elements may play a role in the pathogenesis of heart failure. In the present study, we aimed to assess serum concentrations of selenium (Se), zinc (Zn) and copper (Cu) in patients with heart failure (HF) and to compare idiopathic dilated cardiomyopathy (IDCM) and ischemic cardiomyopathy (ICM) patients with healthy controls. Methods: This study population included 54 HF patients (26 IDCM patients and 28 ICM patients) and 30 healthy subjects. Serum levels of selenium, zinc, and copper were assessed by atomic absorption spectrophotometry method. Results: Serum concentrations of Se and Zn in HF patients were significantly lower than in healthy controls (p=0.000 and p<0.01, respectively). However, serum Cu concentrations in these patients were significantly higher than in controls (p=0.000). There were no significant difference in the trace elements status between IDCM and ICM patients (p>0.05 for all parameters). Relationships of the serum trace element concentrations studied with echocardiographic and hemodynamic parameters were not statistically significant. Conclusion: Our study showed that heart failure is associated with lower Se and Zn concentrations, and higher Cu concentration, and serum Se, Zn and Cu element profiles were similar in IDCM and ICM.