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    Investigation of the cytotoxic effect of Lallemantia Fisch. & C.A. Mey. species growing in Türkiye on various cancer cell lines
    (2024) Çelik, Ali Kaya; Sancar, Pelin Yılmaz; Taşkın, Irmak İçen; Kürşat, Murat
    The genus Lallemantia (Lamiaceae) is popularly known as "Dragonhead". The genus, which has been proven to have extremely rich compounds, is used in the treatment of many diseases among the people. The genus is represented by 5 taxa in the world and 3 taxa are naturally distributed in Türkiye. In this study, the cytotoxic properties of methanolic extracts of the above-ground parts of Lallemantia peltata, Lallemantia iberica and Lallemantia canescens taxa were investigated against BEAS-2B, SH-SY5Y, HCT 116 and Hep G2 cell lines. Changes in the viability of cancer cells were determined using the MTT method. The results showed that all three species had varying degrees of cytotoxic effect. This effect was maximum in L. canescens with 53.54% (p<0.001) on HCT 116, 37.53% (p=0.005) on SH-SY5Y and 32.03% (p=0.026) on Hep G2 at 800 ?g/ml and minimum in L. iberica. In addition, the herbal extracts had no toxic effect on healthy lung cells (BEAS-2B).
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    Investigation the Cytotoxic and Antimicrobial Effect of Ranunculus Poluninii
    (2024) Menevşe, İrem Nur; Taşkın, Irmak İçen; Sancar, Pelin Yılmaz; Kürşat, Murat
    Ranunculus plant species, one of the endemic plants, are used in the treatment of various diseases such as febrile diseases, rheumatism and inflammatory rashes due to their pharmacological and toxicological activities. Considering these features, it was aimed to investigate the cytotoxic effects of Ranunculus poluninii on cancer cell lines, bacteria and yeasts. For this purpose, the extract of the plant was obtained by methanol extraction. Different concentrations of stock were prepared from this plant and applied to A549 and HCT116 cancer cell lines, and MTT assay was performed to determine cell viability. In addition, MIC values were determined by applying the prepared plant extract to Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus, Candida albicans and Candida glabrata. Our results showed that Ranunculus poluninii was reduced cell viability to 83.7% at 100 µg/mL and 79% at 200 µg/mL on A549 and HCT116 respectively. In addition, it decreased both Candida albicans and Candida glabrata growth to 91.5% at 800 µg/m and 95.1% at 50 µg/mL respectively. Our results suggest that Ranunculus poluninii has anticancer effect and antifungal activity.