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    The effects of dental pulp stem cells on bone regeneration in rat calvarial defect model: Micro-computed tomography and histomorphometric analysis
    (Pergamon-Elsevier Science Ltd, 2015) Asutay, Fatih; Polat, Serkan; Gul, Mehmet; Subasi, Cansu; Kahraman, Sevil Altundag; Karaoz, Erdal
    Objective: Stem cell therapies may be applicable to all fields of medicine, including craniomaxillofacial surgery. Dental pulp stem cells also have significant osteogenic properties. This study aimed to evaluate the influence of dental pulp stem cells on bone regeneration and to ascertain whether or not there was any superiority over traditional methods. Design: In this study, 15 non-immunodeficient Wistar albino rats were used. The rats were divided into three groups: (1) untreated control group; (2) hydroxyapatite tri-calcium-phosphate (HA/TCP) paste; (3) human dental pulp derived stem cells (DPSC) mixed with HA/TCP paste (HA/TCP+DSPC group, n = 10). Two symmetrical full-thickness cranial defects were created on each parietal region (10 defects for each group). The animals were sacrificed 8 weeks post-surgery and samples were analyzed by microcomputer tomography (mu-CT) and histomorphometry. Results: The calcification rate and bone mineral density (BMD) values in Group 3 were found to be significantly higher than in the other two groups. Radiographically, bone regeneration was greater in Group 2 compared with the control group. However, there was no significant difference between Groups 2 and 1 in respect of histological analysis. Conclusions: According to the results of the present study, DPSCs may be a suitable factor for bone tissue engineering because they can be easily obtained and differentiate into bone cells. (C) 2015 Elsevier Ltd. All rights reserved.
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    Micro-computed tomography and histomorphometric analysis of the effects of platelet-rich fibrin on bone regeneration in the rabbit calvarium
    (Pergamon-Elsevier Science Ltd, 2015) Acar, Ahmet Huseyin; Yolcu, Umit; Gul, Mehmet; Keles, Ali; Erdem, Necip Fazil; Kahraman, Sevil Altundag
    Objective: The present study aimed to investigate the effectiveness of platelet-rich fibrin (PRF) on bone regeneration when used alone or in combination with hydroxyapatite (HA)/beta-tricalcium phosphate (beta TCP). Design: In this study, 20 New Zealand white rabbits were used and four calvarial defects were prepared in each animal. PEP, Straumann (R) Bone Ceramic (SBC), or PEP + SBC was applied to the defects; one defect was left untreated as a control. Ten rabbits were sacrificed at week 4(T-1) and 10 at week 8 (T-2). After micro-computed tomography (micro-CT) scanning, the samples were sent for histological and histomorphometric analysis to evaluate and compare the volume and area of regenerated bone. Results: Histomorphometric and micro-CT analysis showed that both PEP and SBC significantly increased bone regeneration at T-1 and T-2 (P < 0.01). When PEP was used in combination with HA/beta TCP, a further significant increase in new bone formation was observed at T-1 and T-2 compared with that when PRF or SBC was used alone (P < 0.01). Conclusions: PRF has a positive effect on bone formation when used alone and in combination with HA/beta TCP. (C) 2014 Elsevier Ltd. All rights reserved.