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    Diagnostic role of hair magnesium in migraine patients: higher than serum magnesium?
    (Dustri-Verlag Dr Karl Feistle, 2000) Ilhan, A; Uz, E; Var, A; Kali, S; Akyol, O
    The present study was aimed at evaluating trace element changes and diagnostic role of magnesium levels in hair of migraine patients during interictal period. We assessed trace element levels in hair of migraine patients (n = 40) and control subjects (n = 21). In the group of migraineurs,magnesium (p < 0.05), zinc (p < 0.05), and copper (p < 0.001) levels in the hair were significantly reduced with regard to the control subjects. Although the hair levels of manganese and serum levels of magnesium are lower in migraine patients than the levels in controls, these differences were not found to be signifcant. Also, the mean trace element levels in the group of migraine patients showed no significant difference according to gender, age, and type of migraine (with or without aura). Our data show that some hair trace element levels change in migraine patients during interictal period and hair magnesium seems to be more valuable than serum magnesium as a diagnostic marker in migraine.
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    Jervell and Lange-Nielsen syndrome: Neurologic and cardiologic evaluation
    (Elsevier Science Inc, 1999) Ilhan, A; Tuncer, C; Komsuoglu, SS; Kali, S
    Recurrent syncope, malignant ventricular arrhythmias, and sudden death are complications of the long QT syndrome (LQTS), Two well-known syndromes with long QT intervals are known. The Jervell and Lange-Nielsen syndrome (JLNS) is characterized by prolongation of the QT interval, deafness, and autosomal-recessive inheritance, and the Romano-Ward syndrome is characterized by a prolonged QT interval, autosomal-dominant inheritance, and no deafness. In the present study assessment was performed of the diagnostic importance of the ventricular derepolarization parameters, clinical features, and prevalence of JLNS among 132 children with congenital hearing loss (CHL), In the CHL group the mean QT, QTc, JT, and JTc intervals and the dispersion values (QT-d, JT-d, QTc-d, and JTc-d) were significantly longer than those of control subjects (n = 96) (P < 0.05). Patients with CHL and JLNS (n = 5) had significantly longer mean values of QT, QTc, JT, and JTc intervals and dispersion values than those of CHL without JLNS (n = 127) and control subjects (P < 0.05). The results suggest that assessment of ventricular derepolarization parameters in children with CHL will be helpful in the early detection of JLNS because infants with CHL cannot accurately describe the symptoms of syncope, (C) 1999 by Elsevier Science Inc. All rights reserved.
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    Serum and hair trace element levels in patients with epilepsy and healthy subjects: does the antiepileptic therapy affect the element concentrations of hair?
    (Wiley, 1999) Ilhan, A; Uz, E; Kali, S; Var, A; Akyol, O
    In this study, hair magnesium (Mg), zinc (Zn), copper (Cu), and manganese (Mn) levels, and serum Zn and Mg levels were measured by atomic absorption spectrophotometer in patients with epilepsy (n = 33) and healthy subjects (n = 21), and results obtained were statistically compared. The mean hair Cu, Mg, and Zn levels of epileptic patients were significantly lower than the levels of control subjects. There was no significant difference between epileptic patients and control subjects in respect to the mean Mn levels. Mean serum Mg levels in epileptic patients showed significant difference, but serum Zn levels were similar among both groups. When the effects of anticonvulsant therapy on Cu, Zn, Mn, and Mg in the hair, and Mg and Zn in the serum were analyzed in epileptics, there was no significant difference between the patients with or without therapy. Likewise, the mean trace element levels in epileptics showed no significant difference according to the type of antiepileptic drug and seizure, and gender. We suggest that the changed element status (Zn, Mg, and Cu) in hair may play an indicator role in the diagnosis of epileptic patients, fur J Neurol 6:705-709 (C) 1999 Lippincott Williams & Wilkins.