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    The association between intima media thickness, central obesity and diastolic blood pressure in obese and owerweight children: A cross-sectional school-based study
    (Elsevier Ireland Ltd, 2013) Elkiran, Ozlem; Yilmaz, Erdal; Koc, Mustafa; Kamanli, Ayhan; Ustundag, Bilal; Ilhan, Necip
    Objective: To examine relationship between carotid intima-media thickness (IMT) and central obesity, cardiovasculary risk factors, and chronic inflammation markers in overweight and obese schoolchildren in Eastern Turkey. Methods: A cross-sectional school-based survey on 2765 schoolchildren was performed. We collected the clinical data (age, sex, percentage of body fat, and measured systolic blood pressure [BP] and diastolic BP, triglycerides, high-and low-density lipoprotein cholesterol, glucose, insulin, homocysteine and high-sensitivity C-reactive protein) in 67 obese and 24 overweight children. The control group was composed of nonobese children of similar age and sex. Results: Mean systolic and diastolic BP values in the cases of overweight and obese groups were higher than those in the control group cases (p = 0.001). Obese and overweight children demonstrated a significantly thicker intima media as compared with the control group (p = 0.001). Carotid IMT was significantly correlated to the body mass index (r = 0.396, p = 0.001), fat mass percentage (r = 0.257, p = 0.036), waist circumference (r = 0.390, p = 0.001), diastolic BP (r = 0.266, p = 0.030), glucose (r = 0.250, p = 0.042), and high-sensitivity C-reactive protein levels (r = 0.269, p = 0.001) in the obese group. In multiple linear regression analysis, carotid IMT correlated significantly to waist circumference (p = 0.045), and diastolic BP (p = 0.031) in obese group. Conclusions: Obesity is related to cardiovascular risk factors leading to early atherosclerosis in schoolchildren. There is a relationship between atherosclerosis, and central obesity, diastolic BP, and chronic inflammation. Waist circumference measurement is more sensitive than other anthropometric measurements in predicting obesity and associated complications. (c) 2011 Elsevier Ireland Ltd. All rights reserved.
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    Evaluating loss of productivity in patients with rheumatoid arthritis and its relationship to clinical parameters
    (2018) Sag, Sinem; Nas, Kemal; Sag, Mustafa Serdar; Tekeoglu, Ibrahim; Kamanli, Ayhan; Aydeniz, Aysenur
    Aim: This study investigated loss of productivity of working women and housewives with rheumatoid arthritis (RA) and analyzed the correlation of this loss with disease activity parameters and health-related quality of life. Material and Methods: The study enrolled consecutive patients presenting to rheumatology outpatient clinic between April 2016 and September 2016 who met the American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) RA classification criteria. Disease activity with the Disease Activity Score (DAS-28) as it pertains to C-reactive protein (CRP), functional status with the Duruöz hand index, activities of daily life with the Health Assessment Questionnaire (HAQ), and health-related quality of life with the short-form 36 (SF-36) questionnaire. Results: This study included 82 RA patients (56 women, 26 men) who were followed in our rheumatology outpatient clinic, and 29 healthy controls (24 women, 5 men) who were patient accompanists and patient visitors. We found no difference between housewives and employed women with RA in terms of disease activity, productivity in daily activities, anxiety, or depression, but patients with RA had higher pain, fatigue, and anxiety scores than healthy controls. Loss of productivity in daily activities was found to be correlated with disease activity and fatigue. Conclusions: In conclusion, disease activity, quality of life, and functional status are equally important in RA patients who work as housewives or in the workforce. Emotional status has an impact, especially on increasing productivity and participation in daily life, and doctors should also examine their patients from this perspective
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    Pattern of Disease Onset, Diagnostic Delay, and Clinical Features in Juvenile Onset and Adult Onset Ankylosing Spondylitis
    (J Rheumatol Publ Co, 2009) Ozgocmen, Salih; Ardicoglu, Ozge; Kamanli, Ayhan; Kaya, Arzu; Durmus, Bekir; Yildirim, Kadir; Baysal, Ozlem
    Objective. To assess the frequency of juvenile onset ankylosing spondylitis (JOAS) in Turkish patients with AS and to compare with adult onset AS (AOAS) in a cross-sectional study design. Methods. A total of 322 patients were recruited from the joint database of 5 university hospitals in eastern Turkey. Results. Patients with JOAS (n = 43, 13.4%) had significantly longer diagnostic delay (9.21 vs 5.08 yrs), less severe axial involvement and more prevalent uveitis (OR 2.92, 95% Cl 1.25-6.79), and peripheral involvement at onset (OR 3.25, 95% CI 1.51-6.98, adjusted for current age; and OR 2.26, 95% CI 1.07-4.76, adjusted for disease duration). Patients with AOAS had higher radiographic scores and more restricted clinimetrics but similar functional limitations and quality of life. Conclusion. JOAS and AOAS had distinctive courses and Turkish patients with AS had similar features compared to other Caucasian patient Populations. (First Release Nov 1 2009; J Rheumatol 2009;36:2830-3; doi: 10.3899/jrheum.090435)