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Öğe The association between vitamin D receptor polymorphisms and multiple sclerosis in a Turkish population(Elsevier Sci Ltd, 2018) Kamisli, Ozden; Acar, Ceren; Sozen, Mert; Tecellioglu, Mehmet; Yucel, Fatma Ebru; Vaizoglu, Dilara; Ozcan, CemalBackground: Multiple sclerosis (MS) is a chronic, demyelinating disease of the central nervous system (CNS). Genetic and environmental factors are important in disease development. Many studies have investigated the relationship between MS and VDR polymorphisms. VDR gene polymorphism has not been previously studied in Turkish MS patients. We aimed to investigate the relationship between MS and VDR genotypes Taq I, Apa I and Fok I polymorphisms in a Turkish population. Methods: 167 MS patients and 146 healthy control subjects were included in the present study. MS and the VDR TaqI (rs731236), ApaI (rs7975232), and FokI (rs2228570) polymorphisms were investigated. Results: The study enrolled 167 patients (121 females, 46 males) with MS and 146 healthy individuals (88 females, 58 males). The frequency of only the Fok I polymorphism differed significantly between the two groups (p = 0.002). The TaqI (rs731236) and ApaI (rs7975232) genotype distributions were not significantly different between MS patients and healthy controls (p = 0.626 and p = 0.990, respectively). Also there were no significant gender difference between patients and controls for Taq I and Apa I. Conclusion: In conclusion, we found a significant association between MS and the FokI polymorphism in our region of Turkey. However, the results may be different in other populations. More epidemiological and genetic studies are needed to explain the association between genetic factors and MS.Öğe BK virus-induced acute motor-axonal polyneuropathy in a renal transplant patient(Springer Japan Kk, 2016) Taskapan, Hulya; Kayabas, Uner; Otlu, Baris; Kamisli, Ozden; Yaprak, Cisel Yilmaz; Sahin, Fatma TerziogluNeurological complications are not uncommon in patients with renal transplantation, mostly affecting the central nervous system, and less frequently the peripheral nerves. BK virus infection is relatively common in transplant recipients and in some cases may lead to neurological complications. In this report, we present an interesting case of a patient who developed acute axonal motor polyneuropathy in the course of BK virus infection 3 months after kidney transplantation. After BK virus clearence in blood, a significant improvement was noted in her polyneuropathy. In patients with acute axonal motor polyneuropathy after transplantation BK virus-induced polyneuropathy should be excluded.Öğe Can T2 blackout effect be a marker of iron accumulation in brains of multiple sclerosis patients?(British Inst Radiology, 2020) Erbay, Mehmet Fatih; Kamisli, Ozden; Karatoprak, Nur BetulObjective : T2 blackout (TBO) effect, which is a common finding in the brains of multiple sclerosis (MS) patients and older population that are imaged for other reasons on diffusion weighted imagings (DWI) and apparent diffusion coefficient (ADC) map show the existence of paramagnetic materials in the tissue. Because iron is known to accumulate in especially deep gray matter (DGM) structures in MS brains, we aimed to investigate the relationship between TBO and clinico-radiological parameters that may be iron-related in MS. Methods: We retrospectively reviewed the latest MR images of MS patients on 3 Tesla MR scanner between 2018 and 2019. TBO existence and severity on DWI-ADC was assessed by two radiologists and its correlation with several outcomes of MS was investigated. Results: No significant relationship was found between TBO and gender, subtype of MS whereas TBO was positively correlated with parameters such as black-hole lesions, cortical atrophy, duration of disease, age and extended disability status scale (EDSS) score. Conclusions: TBO shows correlation with the conditions which were revealed to be associated with iron accumulation in the brain of MS patients in the literature. Therefore, we concluded that TBO and its severity in DGM may represent iron accumulation in MS brains. Advances in knowledge: TBO effect as a frequent imaging finding in daily practice may be used as predictor of the disease course of MS due to possible effects of iron accumulation in brain and thereby may be useful in modifying treatment strategies.Öğe A Case of High Grade Glioma following Treatment of Relapsing-remitting Multiple Sclerosis with Fingolimod(Wolters Kluwer Medknow Publications, 2020) Erbay, Mehmet Fatih; Kamisli, OzdenMultiple sclerosis is a major cause of neurological disability, especially in young adults. There have been several case reports of an increased risk of cancer after long-term treatment for multiple sclerosis. Fingolimod is an immunomodulating agent used in the treatment of relapsing -remitting multiple sclerosis. The side effects commonly associated with tingolimod are cardiac side effects, macular edema, and elevated liver enzyme levels. Increased risks of infection and cancer have also been reported. High grade glioma is an aggressive primary brain tumor. There has been one case report of high grade glioma during fingolimod treatment. Here, we report the case of a 58-year-old woman diagnosed with glioblastoma multiforme after one year of tingolimod treatment for multiple sclerosis.Öğe A Case Report of AIDS Dementia Complex(Gazi Univ, Fac Med, 2013) Kamisli, Suat; Kamisli, Ozden; Gonullu, Sinan; Ciplak, SibelInvolvement of nervous system is frequently seen in patients with Acquired Immune Deficiency Syndrome (AIDS). AIDS dementia complex (ADC) is characterized by progressive decline of cognitive and psychomotor functions, and often occurs in the terminal phase of the disease. While our patient was being followed up with the diagnosis of dementia and parkinsonism, clinical signs rapidly progressed. Other conditions that might cause similar symptoms were searched and the patient was diagnosed with ADC based on the clinical, laboratory, and radiological findings. Here, we are reporting a patient with advanced acquired immunodeficiency syndrome (AIDS) who developed dementia as an initial manifestation.Öğe Cerebrospinal Fluid Dynamics in Patients with Multiple Sclerosis: The Role of Phase-Contrast MRI in the Differential Diagnosis of Active and Chronic Disease(Korean Radiological Soc, 2018) Oner, Serkan; Kahraman, Aysegul Sagir; Ozcan, Cemal; Ozdemir, Zeynep Maras; Unlu, Serkan; Kamisli, Ozden; Oner, ZulalObjective: Multiple sclerosis (MS) is an inflammatory disease characterized by demyelinating plaques in the white matter. Chronic cerebrospinal venous insufficiency (CCSVI) has been proposed as a new hypothesis for the etiopathogenesis of MS disease. MS-CCSVI includes a significant decrease of cerebrospinal fluid (CSF) flow through the cerebral aqueduct secondary to an impaired venous outflow from the central nervous system. This study aimed to determine whether CSF flow dynamics are affected in MS patients and the contributions to differential diagnosis in active and chronic disease using phase-contrast magnetic resonance imaging (PC-MRI). Materials and Methods: We studied 16 MS patients with chronic plaques (group 1), 16 MS patients with active plaques-enhanced on MRI (group 2), and 16 healthy controls (group 3). Quantitatively evaluation of the CSF flow was performed from the level of the cerebral aqueduct by PC-MRI. According to heart rates, 14-30 images were obtained in a cardiac cycle. Cardiac triggering was performed prospectively using finger plethysmography. Results: No statistically significant difference was found between the groups regarding average velocity, net forward volume and the average flow (p > 0.05). Compared with the controls, group 1 and group 2, showed a higher peak velocity (5.5 +/- 1.4, 4.9 +/- 1.0, and 4.3 +/- 1.3 cm/sec, respectively; p = 0.040), aqueductal area (5.0 +/- 1.3, 4.1 +/- 1.5, and 3.1 +/- 1.2 mm(2), respectively; p = 0.002), forward volume (0.039 +/- 0.016, 0.031 +/- 0.013, and 0.021 +/- 0.010 mL, respectively; p = 0.002) and reverse volume (0.027 +/- 0.016, 0.018 +/- 0.009, and 0.012 +/- 0.006 mL, respectively; p = 0.000). There were no statistical significance between the MS patients with chronic plaques and active plaques except for reverse volume. The MS patients with chronic plaques showed a significantly higher reverse volume (p = 0.000). Conclusion: This study indicated that CSF flow is affected in MS patients, contrary to the hypothesis that CCSVI-induced CSF flow decreases in MS patients. These findings may be explained by atrophy-dependent ventricular dilatation, which may occur at every stage of MS.Öğe Cluster-Like Headache Associated with Symptomatic Chiari Type 1 Malformation(Galenos Yayincilik, 2014) Kaplan, Yuksel; Kamisli, Ozden[Abstract Not Available]Öğe Effects of phenytoin and lamotrigine treatment on serum BDNF levels in offsprings of epileptic rats(Churchill Livingstone, 2016) Soysal, Handan; Dogan, Zumrut; Kamisli, OzdenThe role of brain-derived neurotrophic factor (BDNF) is to promote and modulate neuronal responses across neurotransmitter systems in the brain. Therefore, abnormal BDNF signaling may be associated with the pathophysiology of schizophrenia. Low BDNF levels have been reported in brains and serums of patients with psychotic disorders. In the present study, we investigated the effects of antiepileptic drugs on BDNF in developing rats. Pregnant rats Were treated with phenytoin (PHT), lamotrigine (LTG) and folic acid for long-term, all through their gestational periods. Experimental epilepsy (EE) model was applied in pregnant rats. Epileptic seizures were determined with electroencephalography. After birth, serum BDNF levels were measured in 136 newborn rats on postnatal day (PND) 21 and postnatal day 38. In postnatal day 21, serum BDNF levels of experimental epilepsy group were significantly lower compared with PHT group. This decrease is statistically significant. Serum BDNF levels increased in the group LTG. This increase compared with LTG + EE group was statistically significant. In the folic acid (FA) group, levels of serum BDNF decreased statistically significantly compared to the PHT group. On postnatal day 38, no significant differences were found among the groups for serum BDNF levels. We concluded that, the passed seizures during pregnancy adversely affect fetal brain development, lowering of serum BDNF levels. PHT use during pregnancy prevents seizure-induced injury by increasing the levels of BDNF. About the increase level of BDNF, LTG is much less effective than PHT, the positive effect of folic acid on serum BDNF levels was not observed. LTG increase in BDNF is much less effective than PHT, folic acid did not show a positive effect on serum BDNF levels. Epilepsy affects fetal brain development during gestation in pregnant rats, therefore anti-epileptic therapy should be continued during pregnancy. (C) 2016 Elsevier Ltd. All rights reserved.Öğe The Efficacy of Lamotrigine and Levetiracetam Therapy on Serum Lipid Profile in Epilepsy Patients(Kare Publ, 2011) Kamisli, Ozden; Kaplan, Yuksel; Kamisli, Suat; Bakir, Meryem; Ozcan, CemalObjectives: We aimed to investigate the efficacy of two new generation antiepileptics, lamotrigine (LTG) and levetiracetam (LEV), on serum lipid levels, since they are reported to be as effective as classical antiepileptics but with fewer side effects. Methods: We analyzed the files of all epileptic patients who were registered at Inonu University Faculty of Medicine, Turgut Ozal Medical Center, Neurology Department between April 2009 - May 2011 retrospectively. Patients treated with LTG and LEV monotherapy were found and total cholesterol (TC), triglyceride, low-density lipoprotein (LDL), very low-density lipoprotein (VLDL) and high-density lipoprotein (HDL) were measured. The patients' data were compared with a control group. Results: Twenty-one patients treated with LTG and 20 patients treated with LEV were included in this study. TC, triglycerides, LDL, VLDL, and HDL values were compared with 21 healthy control subjects. TC, triglycerides, LDL, VLDL, and HDL values showed no statistically significant differences between groups. Conclusion: Neither LEV nor LTG, which are new generation antiepileptics, affected blood lipid levels. We consider that they are safe to use in patients, especially those with atherosclerosis risk.Öğe Epilepsy, Antiepileptic Drugs and Lipid Mechanisms(Kare Publ, 2018) Kamisli, Ozden; Tecellioglu, MehmetHigh levels of lipids and lipoproteins in young adults are significant risk factors for the development of heart disease in older ages. Increased levels of total cholesterol and triglycerides, high levels of low-density lipoprotein and low levels of high-density lipoprotein contribute to cardiovascular disease. Therefore, when starting antiepileptics, it is important to assess changes in serum lipid levels and choose the safety drug, thus contributing to the prevention of cardiovascular complications in older ages. This paper is a review of the e effects of AED use on plasma lipid parameters.Öğe Episodic Paroxysmal Hemicrania with an Atypical Clinical Presentation: A Case Report and Review of the Literature(Turkish Neurological Soc, 2015) Kaplan, Yuksel; Kamisli, Ozden; Altinayar, SibelParoxysmal hemicrania (PH) is characterized by frequent, short-lasting, severe, unilateral headaches that occur in association with cranial autonomic features. The hallmarks of this syndrome are relatively short attacks and a complete therapeutic response to indomethacin. Although PH has been classified as strictly unilateral headache in association with cranial autonomic features, a few cases have been reported that suggest bilateral PH. We report a case of PH with bilateral distribution and bilateral autonomic features. PH may actually represent a clinical spectrum including different phenotypes.Öğe Evaluation of Cervical Vestibular Evoked Myogenic Potentials in Patients with Migraine(Turkish Neurological Soc, 2013) Kaplan, Yuksel; Tecellioglu, Mehmet; Kamisli, Ozden; Kamisli, Suat; Ozcan, CemalObjective: Recent studies have indicated that the brain stem may contribute in the pathogenesis of migraine through different mechanisms. In addition to being used mainly in otologic diseases, vestibular evoked myogenic potentials (VEMP) testing is also used in neurological diseases affecting the brain stem such as stroke and multipl sclerosis in the literature. Studies involving VEMP testing in patients with migraine are novel and few in number. The purpose of this study was to evaluate whether VEMP values in patients with migraine provide additional information regarding the pathogenesis. Methods: This study included 52 patients with migraine and 52 control subjects. In both patients and controls, VEMP examination was performed using click stimuli, and all responses were recorded for both portions of the sternocleidomastoid muscle. Latency, amplitude and threshold values of the P1-N1 wave were compared between the two groups. Results: The amplitude of the left p1 was 4.47 +/- 3.52 mu v in patients and 6.15 +/- 4.79 mu v in the controls, and the difference was statistically significant. On the left, the average difference in the P1-N1 amplitude was 9.04 +/- 6.13 mu v in patients and 12.03 +/- 7.79 mu v in the controls; this difference was also statistically significant. Conclusion: The available studies on the pathophysiology of migraine show that the brain stem is particularly affected at the upper part. However, VEMP testing is mainly used for the assessment of the neuronal pathway starting from the saccula-macula and finishing at the sternocleidomastoid muscle in the lower brain stem. In this study, the only significant differences in amplitude were found in left-P1 and P1-N1. The results of our study show that in patients with migraine, neuroanatomical structures in the lower brain stem can be asymmetrically affected.Öğe The Evaluation of Premenstrual Dysphoric Disorder Incidence and it's Relationship with Antiepileptic Drugs in Epilepsy Patients(Kare Publ, 2013) Kamisli, Ozden; Kamisli, Suat; Kartalci, Sukru; Bakir, Meryem; Kaplan, Yuksel; Ozcan, CemalObjectives: Premenstrual dysphoric disorder (PMDD) is a condition characterized by psychiatric and somatic symptoms commonly seen in women of childbearing age. There are few studies investigating the prevalence of PMDD in patients with epilepsy. In this study we investigate the frequency of PMDD in epilepsy patients and evaluate the relationship between antiepileptic drugs and PMDD. Methods: The subjects were 93 women with epilepsy and 30 controls. Patients were divided into five subgroups according to their medications as carbamazepine, oxcarbazepine, valproic acide, lamotrigine, and levetiracetam. Each group were examined for the frequency of PMDD. In addition, the incidence of PMDD was compared according to antiepileptic drugs in subgroups. Results: The frequency of PMDD was similar in patients with and without epilepsy. Focal epilepsy group, especially temporal lobe epilepsy, has a higher incidence of PMDD, but similar results were also found in women without epilepsy. Looking at the relationship between antiepileptic treatments and PMDD, patients treated with lamotrigine had the lowest frequency. Conclusion: The frequency of PMDD was similar in patients with and without epilepsy. Focal epilepsy patients, especially temporal lobe epilepsy patients, had a higher incidence of PMDD. The LTG group had the lowest rate of PMDD. In terms of PMDD, LTG may be beneficial for young women with epilepsy.Öğe The evaluation of sensory gating with P50 paradigm in chronic obstructive pulmonary disease(European Respiratory Soc Journals Ltd, 2012) Kamisli, Ozden; Ermis, Hilal; Kamisli, Suat; Gulbas, Gazi; Ozcan, Cemal[Abstract Not Available]Öğe Fish oil protects the peripheral and central nervous systems against cisplatin-induced neurotoxicity(Maney Publishing, 2014) Kamisli, Suat; Ciftci, Osman; Cetin, Asli; Kaya, Kursat; Kamisli, Ozden; Celik, HamitObjective: The protective effects of fish oil (FO) on cisplatin (CP)-induced central and peripheral neurotoxicity were investigated in rats. Methods: Rats (n = 28) were divided equally into four groups, the first group was kept as a control. In the second and third groups, CP and FO were given at doses of 7 mg/kg and 1 softgel/rat/day, respectively. In the fourth group, CP and FO were given together at the same doses. Results: Although CP caused significant oxidative damage, via induction of lipid peroxidation and reduction in the antioxidant defense system potency, FO treatment largely reversed these effects. CP also resulted in histopathological damage, such as apoptosis, and electromyographical changes in the sciatic nerve. FO treatment partially prevented the histopathological and electromyographical effects of CP. Discussion: CP has severe central and peripheral neurotoxic effects in rats and these effects were largely prevented by FO treatment. Thus, it appears that co-administration of FO with CP may be a useful approach to attenuate the negative effects of CP on the nervous system.Öğe HaNDL Syndrome Presenting During Pregnancy: A Case Report and Review of the Literature(Turkish Neurological Soc, 2014) Kablan, Yuksel; Kamisli, Ozden; Celik, HamitHeadache associated with neurological deficits and cerebrospinal fluid lymphocytosis (HaNDL) is a self-limiting syndrome characterized by sudden-onset headache with a temporary neurological deficit and cerebrospinal fluid (CSF) lymphocytosis. We aimed to disscus a case of HaNDL syndrome presenting during pregnancy with relevant literature. A 20-year-old female presented with a 5-day history of severe, bilateral throbbing headache accompanied by nausea, vomiting, and phonophobia. Approximately 2 days after the pain developed, she became acutely confused for less than 90 minutes. Two days after this episode, she experienced another confusional state and left hemiparesis. There were no symptoms consistent with meningoencephalitis. She was in her 11th week of pregnancy. A neurologic examination showed confusion, bilateral papilledema, and mild left hemiparesis. The neuroradiological examination was normal. The cerebrospinal fluid revealed lymphocytic pleocytosis, mildly elevated protein, and increased opening pressure. She recovered completely after 8 days. The precise etiology of HaNDL is unknown, although an inflammatory or infectious origin and autoimmune factors have been proposed. Moreover, the risk factors and medical conditions associated with HaNDL are also unknown. It is difficult to determine whether the pregnancy was coincidental or associated in this case. We believe that comprehensive studies are needed to clarify the risk factors and medical conditions associated with HaNDL.Öğe Hesperidin protects brain and sciatic nerve tissues against cisplatin-induced oxidative, histological and electromyographical side effects in rats(Sage Publications Inc, 2015) Kamisli, Suat; Ciftci, Osman; Kaya, Kursat; Cetin, Asli; Kamisli, Ozden; Ozcan, CemalIn the present study, the beneficial effect of hesperidin (HP), a citrus flavonoid, on cisplatin (CP)-induced neurotoxicity was investigated. A total of 28 rats were equally divided into four groups; the first group was kept as control. In the second and third groups, CP and HP were given at the doses of 7 and 50 mg/kg/day, respectively. In the fourth group, CP and HP were given together at the same doses. The results indicated that although CP caused significant induction of lipid peroxidations and reduction in the antioxidant defense system potency in the brain and sciatic nerve, HP prevented these effects of CP. Besides, CP led to histopathological damage, mainly apoptosis, as well as electromyographical (EMG) changes in sciatic nerve. On the other hand, HP treatment reversed histopathological and EMG effects of CP. In conclusion, CP had severe dose-limiting neurotoxic effects and these effects of CP can be prevented by HP treatment. Thus, it appears that coadministration of HP with CP may be a useful approach to attenuate the negative effects of CP on the nervous system.Öğe Hesperidin, a Citrus Flavonoid, Has the Ameliorative Effects Against Experimental Autoimmune Encephalomyelitis (EAE) in a C57BL/J6 Mouse Model(Springer/Plenum Publishers, 2015) Ciftci, Osman; Ozcan, Cemal; Kamisli, Ozden; Cetin, Asli; Basak, Nese; Aytac, BilalThe aim of this study was determined the effects of Hesperidin (HP) on neuronal damage in brain tissue caused by Experimental allergic encephalomyelitis (EAE), an established model of multiple sclerosis in C57BL/J6 mice. To explore 40 mice were equally divided into four groups: (1) Control, (2) EAE, (3) HP, and (4) HP + EAE. 14 days after induction of EAE with MOG35-55 and pertussis toxin, the mice treated with HP at the doses of 50 mg/kg/day for 7 days subcutaneously. To our results HP treatment prevents the oxidative stress caused by EAE via a decrease in lipid peroxidations and increase in elements of the antioxidant defense systems in brain tissue. Also, EAE elevate the IL-17, express the pro-inflammatory cytokines, and caspase-3-like immunreactivity, show apoptosis, staining in EAE mice brain and increased the incidence of histopathological damage. However, immonohistochemical and histological changes were reversed with HP. Moreover, elevated TNF-alpha and IL-1 beta levels, a result of EAE, were decreased in serum and neurological deficits as clinical signs were reversed with HP treatment in EAE mice, given HP. In conclusion, HP treatment effectively prevents oxidative, immunological and histological damage in the brain caused by EAE. It was thought that the beneficial effects of HP are likely a result of its strong antioxidant and anti-inflammatory properties.Öğe Investigation of neuromuscular transmission in patients with chronic obstructive pulmonary disease: A preliminary report(European Respiratory Soc Journals Ltd, 2012) Kaplan, Yuksel; Gulbas, Gazi; Ermis, Hilal; Kamisli, Ozden; Kamisli, Suat; Ozcan, Cemal[Abstract Not Available]Öğe Is there a relationship between Toxoplasma gondii infection and idiopathic Parkinson's disease?(Informa Healthcare, 2010) Celik, Tuncay; Kamisli, Ozden; Babur, Cahit; Cevik, Muhammer Ozgur; Oztuna, Derya; Altinayar, SibelIdiopathic Parkinson's disease defines a group of Parkinson's disease (PD) of which the aetiology is unknown but an underlying brain disease is suspected. We selected patients of this subgroup of PD and investigated the seropositivity rate for anti-Toxoplasma IgG antibody by Sabin-Feldman dye test (SFDT). By measuring seropositivity in PD patients, we searched for a probable relationship between Toxoplasma gondii infection and idiopathic PD incidence. Fifty patients diagnosed with idiopathic PD and 50 healthy volunteers were included in the study. Blood samples were taken from all 100 participants and anti-T. gondii antibody titres were investigated using SFDT. Anti-T. gondii antibodies were detected at a titre of >= 1/16 in 25 of the 50 patients (50%) and in 20 of the control group (40%). No higher antibody titre was found in the control group. In conclusion, despite the emerging literature on a possible relationship between T. gondii infection and neurological disease, and the high anti-T. gondii seropositivity found in our PD patients, we did not detect any statistically significant association between T. gondii and idiopathic PD.
