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    Comment on 'Modified intralesional aciclovir therapy in the management of recalcitrant palmoplantar and ungual warts: a case series of 14 patients'
    (Oxford Univ Press, 2025) Altunisik, Nihal; Kanat, Zekiye; Sezer, Suat; Turkmen, Dursun
    [No abstract available]
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    Demodex parasite density in patients with melasma: a case-control study
    (Taylor & Francis Ltd, 2026) Baran, Fatma Bengisu; Altunisik, Nihal; Turkmen, Dursun; Kanat, Zekiye; Sener, Serpil
    Background: Although multiple factors contribute to the development of melasma, there are reports suggesting a potential role of Demodex parasites in hyperpigmentation. This study aimed to compare the density and prevalence of Demodex infestation between patients with melasma and healthy controls. Methods: This case-control study included 35 melasma patients and 35 healthy volunteers. Standard superficial skin biopsies using cyanoacrylate adhesive were taken from the malar regions. Samples were examined via light microscopy, with a density of >= 5 Demodex/cm(2) defined as positive. Results: No statistically significant difference was found between the melasma and control groups in terms of Demodex mite density or positivity rates. Correlation analysis revealed no significant relationship between mMASI scores and Demodex mite density. As a secondary finding, the mean mMASI score was significantly higher in male participants compared to female participants. Conclusion: In this case-control study, we found no statistically significant association between Demodex parasite density and melasma in our study population. While our findings do not support an association in this sample, future large-scale and multicenter studies could further explore the potential role of Demodex in skin disorders that have been suggested by other reports. The single-center design and moderate sample size should be considered when interpreting these results.
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    Knee Arthralgia and Cartilage Thinning in Psoriasis: Clues to Early Psoriatic Arthritis?
    (Wiley, 2025) Akturk, Semra; Buyukavci, Raikan; Zontul, Sezgin; Kanat, Zekiye; Altunisik, Nihal; Altun, Belda; Simsek, Emrah
    Background: To compare femoral cartilage thickness between patients with psoriasis (PsO) and psoriatic arthritis (PsA), and to investigate whether knee joint pain in PsO patients could be an early risk factor for PsA. Methods: Fifty-nine patients (28 PsO and 31 PsA) were included in this cross-sectional study. Demographic data were collected, and clinical assessments were performed using the Psoriasis Area and Severity Index (PASI) and the Disease Activity Score 28 (DAS28). PsO patients were evaluated for knee arthralgia symptoms within the past month. Femoral cartilage thickness was measured bilaterally at the medial femoral condyle, lateral femoral condyle, and intercondylar area using ultrasonography. Results: Femoral cartilage thickness was significantly lower in PsA patients compared to those with PsO (p < 0.05). Among patients with PsO, those reporting arthralgia (n = 14) had significantly reduced lateral femoral condyle cartilage thickness in both knees compared to those without arthralgia (p < 0.05). Spearman correlation analysis revealed a negative correlation between age and lateral cartilage thickness (e.g., right LFC: rho = -0.338, p = 0.009, 95% CI -0.55 to -0.09). PASI scores showed a consistent positive correlation with femoral cartilage thickness across regions; for example, the correlation with the left LFC was significant (rho = 0.504, p < 0.01, 95% CI 0.29-0.67). These associations indicate that both demographic and disease-related factors may influence cartilage status in PsO and PsA, although the confidence intervals indicate some degree of uncertainty and call for validation in larger cohorts. Conclusions: Femoral cartilage thinning is evident in PsA patients and may begin even in the subclinical phase. In PsO patients, the presence of arthralgia, especially in the lateral femoral condyle, may reflect early structural changes and could serve as a predictor for PsA development. Ultrasonographic assessment offers a noninvasive, accessible method for early detection and follow-up.